Effectiveness and Cost-Effectiveness of Treatment as Prevention for HIV

2017 ◽  
pp. 91-111 ◽  
Author(s):  
Charles B. Holmes ◽  
Timothy B. Hallett ◽  
Rochelle P. Walensky ◽  
Till Bärnighausen ◽  
Yogan Pillay ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Treatment As Prevention

scholarly journals Cost-Effectiveness of HIV Treatment as Prevention in Serodiscordant Couples

2013 ◽  
Vol 369 (18) ◽  
pp. 1715-1725 ◽  
Author(s):  
Rochelle P. Walensky ◽  
Eric L. Ross ◽  
Nagalingeswaran Kumarasamy ◽  
Robin Wood ◽  
Farzad Noubary ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Hiv Treatment ◽  
Treatment As Prevention ◽  
Serodiscordant Couples ◽  
Hiv Treatment As Prevention

scholarly journals Population Health and Cost-Effectiveness Implications of a “Treat All” Recommendation for HCV: A Review of the Model-Based Evidence

2018 ◽  
Vol 3 (1) ◽  
pp. 238146831877663 ◽  
Author(s):  
Lauren E. Cipriano ◽  
Jeremy D. Goldhaber-Fiebert
Keyword(s):  
Cost Effectiveness ◽  
Population Health ◽  
Cost Effective ◽  
World Health ◽  
Health Impacts ◽  
Treatment As Prevention ◽  
Treatment Access ◽  
Model Based ◽  
Treat All ◽  
Access Policies

The World Health Organization HCV Guideline Development Group is considering a “treat all” recommendation for persons infected with hepatitis C virus (HCV). We reviewed the model-based evidence of cost-effectiveness and population health impacts comparing expanded treatment policies to more limited treatment access policies, focusing primarily on evaluations of all-oral directly acting antivirals published after 2012. Searching PubMed, we identified 2,917 unique titles. Sequentially reviewing titles and abstracts identified 226 potentially relevant articles for full-text review. Sixty-nine articles met all inclusion criteria—42 cost-effectiveness analyses and 30 models of population-health impacts, with 3 articles presenting both types of analysis. Cost-effectiveness studies for many countries concluded that expanding treatment to people with mild liver fibrosis, who inject drugs (PWID), or who are incarcerated is generally cost-effective compared to more restrictive treatment access policies at country-specific prices. For certain patient subpopulations in some countries—for example, elderly individuals without fibrosis—treatment is only cost-effective at lower prices. A frequent limitation is the omission of benefits and consequences of HCV transmission (i.e., treatment as prevention; risks of reinfection), which may underestimate or overestimate the cost-effectiveness of a “treat all” policy. Epidemiologic modeling studies project that through a combination of prevention, aggressive screening and diagnosis, and prompt treatment for all fibrosis stages, it may be possible to virtually eliminate HCV in many countries. Studies show that if resources are not available to diagnose and treat all HCV-infected individuals, treatment prioritization may be needed, with alternative prioritization strategies resulting in tradeoffs between reducing mortality or reducing incidence. Notably, because most new HCV infections are among PWID in many settings, HCV elimination requires unrestricted treatment access combined with injection transmission disruption strategies. The model-based evidence suggests that a properly constructed strategy that substantially expands HCV treatment could achieve cost-effective improvements in population health in many countries.

Cost-effectiveness of dental implants: a utility analysis

1990 ◽  
Vol 54 (11) ◽  
pp. 688-689 ◽  
Author(s):  
J Jacobson ◽  
B Maxson ◽  
K Mays ◽  
J Peebles ◽  
C Kowalski
Keyword(s):  
Cost Effectiveness ◽  
Dental Implants ◽  
Utility Analysis

160: Cost-Effectiveness of Medical Management Strategies of Nephrolithiasis in Different Health Care Systems

2004 ◽  
Vol 171 (4S) ◽  
pp. 42-43 ◽  
Author(s):  
Yair Latan ◽  
David M. Wilhelm ◽  
David A. Duchene ◽  
Margaret S. Pearle
Keyword(s):  
Health Care ◽  
Cost Effectiveness ◽  
Medical Management ◽  
Health Care Systems ◽  
Management Strategies ◽  
Care Systems
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