G-protein-coupled receptor controls steroid hormone signaling in cell membrane

2016 ◽  
Author(s):  
Di Wang
Keyword(s):  
Cell Membrane ◽  
G Protein ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
G Protein Coupled Receptor ◽  
Steroid Hormone Signaling ◽  
G Protein Coupled

scholarly journals G-protein-coupled receptor controls steroid hormone signaling in cell membrane

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Di Wang ◽  
Wen-Li Zhao ◽  
Mei-Juan Cai ◽  
Jin-Xing Wang ◽  
Xiao-Fan Zhao
Keyword(s):  
Cell Membrane ◽  
G Protein ◽  
Steroid Hormone ◽  
Hormone Signaling ◽  
G Protein Coupled Receptor ◽  
Steroid Hormone Signaling ◽  
G Protein Coupled

scholarly journals Effect of Ligand Binding on the Diffusion and Distribution of the G Protein-Coupled Receptor CCR5 in the Cell Membrane

2012 ◽  
Vol 102 (3) ◽  
pp. 512a-513a
Author(s):  
Zuleika Calderin-Sollet ◽  
Oliver Hartley ◽  
Alexandre Fuerstenberg
Keyword(s):  
Cell Membrane ◽  
Ligand Binding ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Receptor Ccr5

scholarly journals G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiao-Fan Zhao
Keyword(s):  
Cell Membrane ◽  
Steroid Hormones ◽  
G Protein ◽  
Steroid Hormone ◽  
G Protein Coupled Receptors ◽  
Membrane Receptors ◽  
Research Progress ◽  
Nongenomic Action ◽  
Signaling Axis ◽  
G Protein Coupled

Abstract G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands. Recent studies have suggested that GPCRs transmit animal steroid hormone signals. Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects. This review summarizes the research progress on GPCRs as animal steroid hormone cell membrane receptors, including the nuclear and cell membrane receptors of steroid hormones in mammals and insects, the 20E signaling cascade via GPCRs, termination of 20E signaling, and the relationship between genomic action and the nongenomic action of 20E. Studies indicate that 20E induces a signal via GPCRs to regulate rapid cellular responses, including rapid Ca2+ release from the endoplasmic reticulum and influx from the extracellular medium, as well as rapid protein phosphorylation and subcellular translocation. 20E via the GPCR/Ca2+/PKC/signaling axis and the GPCR/cAMP/PKA-signaling axis regulates gene transcription by adjusting transcription complex formation and DNA binding activity. GPCRs can bind 20E in the cell membrane and after being isolated, suggesting GPCRs as cell membrane receptors of 20E. This review deepens our understanding of GPCRs as steroid hormone cell membrane receptors and the GPCR-mediated signaling pathway of 20E (20E-GPCR pathway), which will promote further study of steroid hormone signaling via GPCRs, and presents GPCRs as targets to explore new pharmaceutical materials to treat steroid hormone-related diseases or control pest insects. Graphical abstract

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