Sensitivity analysis has received significant attention in engineering design. While sensitivity analysis methods can be global, taking into account all variations, or local, taking into account small variations, they generally identify which uncertain parameters are most important and to what extent their effect might be on design performance. The extant methods do not, in general, tackle the question of which ranges of parameter uncertainty are most important or how to best allocate investments to partial uncertainty reduction in parameters under a limited budget. More specifically, no previous approach has been reported that can handle single-disciplinary multi-output global sensitivity analysis for both a single design and multiple designs under interval uncertainty. Two new global uncertainty metrics, i.e., radius of output sensitivity region and multi-output entropy performance, are presented. With these metrics, a multi-objective optimization model is developed and solved to obtain fractional levels of parameter uncertainty reduction that provide the greatest payoff in system performance for the least amount of “investment”. Two case studies of varying difficulty are presented to demonstrate the applicability of the proposed approach.
SENSITIVITY ANALYSIS FOR THE OPTIMIZATION OF RADIOFREQUENCY ABLATION IN THE PRESENCE OF MATERIAL PARAMETER UNCERTAINTY
