Large-scale longitudinal vortices in high-speed turbulent separated flows caused by relatively small irregularities at the model leading edges or at the model surfaces are investigated in this paper. Oil-flow visualization and infrared thermography techniques were applied in the wind tunnel tests at Mach numbers 3 and 5 to investigate the nominally 2-D ramp flow at deflection angles of 20°, 25° and 30°. The surface contour anomalies have been artificially simulated by very thin strips (vortex generators) of different shapes and thicknesses attached to the model surface. It is shown that the introduced streamwise vortical disturbances survive over very large downstream distances of the order of 104 vortex-generator heights in turbulent supersonic flows without pressure gradients. It is demonstrated that each vortex pair induced in the reattachment region of the ramp is definitely a child of a vortex pair, which was generated originally, for instance, by the small roughness element near the leading edge. The dependence of the spacing and intensity of the observed longitudinal vortices on the introduced disturbances (thickness and spanwise size of vortex generators) and on the flow parameters (Reynolds numbers, boundary-layer thickness, compression corner angles, etc.) has been shown experimentally.