scholarly journals Growth Inhibitory Effect of Krüppel-like Factor 6 on Human Prostatic Carcinoma and Renal Carcinoma Cell Lines

2008 ◽  
Vol 216 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Xian-Feng Cheng ◽  
Di Li ◽  
Min Zhuang ◽  
Zhao-Yan Chen ◽  
De-Xiang Lu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Prostatic Carcinoma ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Carcinoma Cell Lines ◽  
Growth Inhibitory

Growth-inhibitory effects of TNF-alpha and alltrans retinoic acid on human renal carcinoma cell lines

1995 ◽  
Vol 121 (S1) ◽  
pp. A53-A53
Author(s):  
C. D. Gerharz ◽  
P. Reinecke ◽  
U. Ramp ◽  
K. Jaquet ◽  
M. Dienst ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Lines ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Tnf Alpha ◽  
Inhibitory Effects ◽  
Carcinoma Cell Lines ◽  
Growth Inhibitory ◽  
Human Renal Carcinoma

scholarly journals Multiple effects of N-a-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines

2004 ◽  
Vol 3 (8) ◽  
pp. 761-768 ◽  
Author(s):  
Oskar W. Rokhlin ◽  
Natalya V. Guseva ◽  
Agshin F. Taghiyev ◽  
Rebecca A. Glover ◽  
Michael B. Cohen
Keyword(s):  
Cell Lines ◽  
Prostatic Carcinoma ◽  
Carcinoma Cell ◽  
Chloromethyl Ketone ◽  
Carcinoma Cell Lines ◽  
Apoptotic Pathways

scholarly journals pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Javier Sevilla-Montero ◽  
Raquel Bienes-Martínez ◽  
David Labrousse-Arias ◽  
Esther Fuertes-Yebra ◽  
Ángel Ordóñez ◽  
...  
Keyword(s):  
Cell Lines ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Renal Carcinoma ◽  
Carcinoma Cell Lines ◽  
Thrombospondin 1 ◽  
Cell Renal Carcinoma

scholarly journals Inhibitory effect of vitamin K1 on growth and polyamine biosynthesis of human gastric and colon carcinoma cell lines

2015 ◽  
Vol 47 (2) ◽  
pp. 773-781 ◽  
Author(s):  
MICHELE LINSALATA ◽  
ANTONELLA ORLANDO ◽  
VALERIA TUTINO ◽  
MARIA NOTARNICOLA ◽  
BENEDETTA D’ATTOMA ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Inhibitory Effect ◽  
Vitamin K1 ◽  
Polyamine Biosynthesis ◽  
Carcinoma Cell Lines

scholarly journals Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1578
Author(s):  
Pedro Brandão ◽  
Joana Moreira ◽  
Joana Almeida ◽  
Nair Nazareth ◽  
Ivo E. Sampaio-Dias ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Human Tumor ◽  
Colon Adenocarcinoma ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Protein Levels ◽  
Cycle Arrest ◽  
Growth Inhibitory ◽  
Potent Growth

Hierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma HT-29 cells. Aiming to improve the potential antitumor activity of this natural product, the demethylated analogue, norhierridin B (10), as well as its structurally-related quinone (9), were synthesized and evaluated for their growth inhibitory effect on a panel of human tumor cell lines, including the triple-negative breast cancer (TNBC) cells MDA-MB-231, SKBR3, and MDA-MB-468. Norhierridin B (10) showed a potent growth inhibitory effect on all cancer cell lines. Moreover, the growth inhibitory effect of compound 10 on MDA-MB-231 cells was associated with cell cycle arrest and apoptosis. Norhierridin B (10) interfered with several p53 transcriptional targets, increasing p21, Bax, and MDM2, while decreasing Bcl-2 protein levels, which suggested the potential activation of a p53 pathway. Altogether, these results evidenced a great improvement of the antitumor activity of hydroquinone 10 when compared to 6 and its structurally-related quinone (9). Notably, hydroquinone 10 displayed a prominent growth inhibitory activity against TNBC cells, which are characterized by high therapeutic resistance.

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