HORMONAL CONTROL OF ZINC IN MATURE RAT TESTIS

1961 ◽  
Vol 23 (1) ◽  
pp. 37-45 ◽  
Author(s):  
S. A. GUNN ◽  
THELMA C. GOULD ◽  
W. A. D. ANDERSON
Keyword(s):  
Growth Hormone ◽  
Interstitial Cell ◽  
Follicle Stimulating Hormone ◽  
Hormonal Control ◽  
Rat Testis ◽  
Zn Uptake ◽  
Interstitial Elements ◽  
Stimulating Hormone

SUMMARY Eleven days following hypophysectomy the capacity of the rat testis to take up administered 65Zn is markedly depressed below values noted in intact controls, even though microscopically there is only a slight diminution in the number of germinal epithelial and interstitial elements. Interstitial cell-stimulating hormone (ICSH) in doses of 5 μg./day administered from the 5th to the 10th day after operation completely prevented the fall in total 65Zn uptake of the testis following removal of the pituitary. Follicle stimulating hormone (FSH) was less effective than ICSH in this regard. The possibility of the FSH effect being due to contamination with ICSH is considered. Growth hormone and prolactin in doses of 200 μg./day administered from the 5th to 10th day after operation were ineffective in preventing the fall in 65Zn uptake of the testis following hypophysectomy.

THE EFFECT OF GROWTH HORMONE AND PROLACTIN PREPARATIONS ON THE CONTROL BY INTERSTITIAL CELL-STIMULATING HORMONE OF UPTAKE OF 65Zn BY THE RAT DORSOLATERAL PROSTATE

1965 ◽  
Vol 32 (2) ◽  
pp. 205-214 ◽  
Author(s):  
S. A. GUNN ◽  
THELMA C. GOULD ◽  
W. A. D. ANDERSON
Keyword(s):  
Growth Hormone ◽  
Interstitial Cell ◽  
Prostate Gland ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Sprague Dawley ◽  
Zn Uptake ◽  
Significant Augmentation ◽  
Consistent Parameter ◽  
Stimulating Hormone

SUMMARY Five pituitary hormones: follicle-stimulating hormone (FSH), adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), growth hormone and prolactin, were tested for their capacity to alter the control by interstitial cell-stimulating hormone (ICSH) of the uptake of 65Zn by the dorsolateral prostate gland of the mature hypophysectomized Sprague-Dawley rat. Only prolactin and growth hormone produced significant augmentation of the response to ICSH. Contamination with growth hormone was apparently not responsible for the augmentation of ICSH activity brought about by the NIH-prolactin preparation used. NIH-prolactin and a highly purified preparation provided by Dr C. H. Li were shown to be equally effective in their capacity to augment the 65Zn-uptake response produced by ICSH. Augmentation was detectable with total doses of prolactin as low as 10–30 μg. (0·21–0·63 i.u.). Prolactin caused an augmentation of testosterone activity on uptake of 65Zn in the hypophysectomized and castrated rat, indicating an effect of prolactin on the prostate that is not mediated by the testis. NIH-growth hormone was not as effective as the prolactin preparations in enhancing ICSH activity, but in sufficient doses produced a significant increase in the 65Zn-uptake response to ICSH. These studies showed also that the uptake of 65Zn of the dorsolateral prostate was a more sensitive and more consistent parameter than glandular weight for the detection of augmentation of ICSH response by growth hormone or prolactin preparations.

Growth hormone enhances estradiol production follicle-stimulating hormone-induced in the early stage of the follicular maturation

1996 ◽  
Vol 66 (6) ◽  
pp. 948-953 ◽  
Author(s):  
Antonio Lanzone ◽  
Antonio Fortini ◽  
Anna Maria Fulghesu ◽  
Liberato Soranna ◽  
Alessandro Caruso ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Early Stage ◽  
Follicle Stimulating Hormone ◽  
Follicular Maturation ◽  
Stimulating Hormone

Impact of growth hormone (GH) and follicle stimulating hormone (FSH) on in vitro canine preantral follicle development and estradiol production

2015 ◽  
Vol 25 (2) ◽  
pp. 85-89 ◽  
Author(s):  
M.K.B. Serafim ◽  
A.B.G. Duarte ◽  
G.M. Silva ◽  
C.E.A. Souza ◽  
D.M. Magalhães-Padilha ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Follicle Stimulating Hormone ◽  
Follicle Development ◽  
Preantral Follicle ◽  
Stimulating Hormone

Pituitary-bone connection in skeletal regulation

2016 ◽  
Vol 28 (2) ◽  
Author(s):  
Mone Zaidi ◽  
Li Sun ◽  
Peng Liu ◽  
Terry F. Davies ◽  
Maria New ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Follicle Stimulating Hormone ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Bone Diseases ◽  
Adrenocorticotrophic Hormone ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone ◽  
Limited Function ◽  
Stimulating Hormone

AbstractPituitary hormones have traditionally been thought to exert specific, but limited function on target tissues. More recently, the discovery of these hormones and their receptors in organs such as the skeleton suggests that pituitary hormones have more ubiquitous functions. Here, we discuss the interaction of growth hormone (GH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin, oxytocin and arginine vasopressin (AVP) with bone. The direct skeletal action of pituitary hormones therefore provides new insights and therapeutic opportunities for metabolic bone diseases, prominently osteoporosis.

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