FOLLICLE-STIMULATING HORMONE (FSH) AND INTERSTITIAL-CELL-STIMULATING HORMONE (ICSH) IN PITUITARY AND PLASMA OF INTACT AND OVARIECTOMIZED PROTEINDEFICIENT RATS12

ABSTRACT A preparation of ovine follicle stimulating hormone (FSH) which is approximately 50 times as active as NIH-FSH-S1 has been tested in hypophysectomized male and female rats and found to be a potent steroidogenic factor. Contamination of the FSH preparation with interstitial cell-stimulating hormone (ICSH, LH) was found to be very low (0.006–0.016 unit/mg) and could not account for the observed activity. In addition, treatment of the FSH preparation with 6 m urea and neuraminidase indicates that the steroidogenic activity is either an intrinsic property of the FSH molecule or a discrete entity which differs chemically from ICSH.

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HUMAN URINARY GONADOTROPHINS

Journal of Endocrinology ◽

10.1677/joe.0.0180046 ◽

1959 ◽

Vol 18 (1) ◽

pp. 46-55 ◽

Cited By ~ 19

Author(s):

P. S. BROWN

Keyword(s):

Menstrual Cycle ◽

Interstitial Cell ◽

Follicle Stimulating Hormone ◽

Secondary Amenorrhoea ◽

Stimulating Hormone

SUMMARY Urinary gonadotrophins were assayed against HMG 20 A during the menstrual cycle in four subjects by methods believed to measure follicle stimulating hormone (FSH) and total gonadotrophin respectively. The gonadotrophins showed qualitative fluctuation. Three subjects showed maximum levels of total gonadotrophin near the middle of the cycle, and three showed a notably different pattern of excretion of FSH with high values in the first part of the cycle. Gonadotrophins from patients with secondary amenorrhoea showed no qualitative fluctuation, but treatment with stilboestrol apparently caused a rise in excretion of interstitial cell stimulating hormone in three out of nine patients. The results of ninety-eight assays are recorded with fiducial limits and are discussed with reference to the specificity of the methods and the importance of inter-assay errors.

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FOLLICLE STIMULATING HORMONE (FSH) AND INTERSTITIAL CELL STIMULATING HORMONE (ICSH) IN RELATION TO GAMETIC OUTPUT IN 643 MALES

Obstetrical & Gynecological Survey ◽

10.1097/00006254-197310000-00017 ◽

1973 ◽

Vol 28 (10) ◽

pp. 734-735 ◽

Cited By ~ 1

Author(s):

Berndt Kjessler ◽

Leif Wide

Keyword(s):

Interstitial Cell ◽

Follicle Stimulating Hormone ◽

Stimulating Hormone

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HORMONAL CONTROL OF ZINC IN MATURE RAT TESTIS

Journal of Endocrinology ◽

10.1677/joe.0.0230037 ◽

1961 ◽

Vol 23 (1) ◽

pp. 37-45 ◽

Cited By ~ 22

Author(s):

S. A. GUNN ◽

THELMA C. GOULD ◽

W. A. D. ANDERSON

Keyword(s):

Growth Hormone ◽

Interstitial Cell ◽

Follicle Stimulating Hormone ◽

Hormonal Control ◽

Rat Testis ◽

Zn Uptake ◽

Interstitial Elements ◽

Stimulating Hormone

SUMMARY Eleven days following hypophysectomy the capacity of the rat testis to take up administered 65Zn is markedly depressed below values noted in intact controls, even though microscopically there is only a slight diminution in the number of germinal epithelial and interstitial elements. Interstitial cell-stimulating hormone (ICSH) in doses of 5 μg./day administered from the 5th to the 10th day after operation completely prevented the fall in total 65Zn uptake of the testis following removal of the pituitary. Follicle stimulating hormone (FSH) was less effective than ICSH in this regard. The possibility of the FSH effect being due to contamination with ICSH is considered. Growth hormone and prolactin in doses of 200 μg./day administered from the 5th to 10th day after operation were ineffective in preventing the fall in 65Zn uptake of the testis following hypophysectomy.

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EFFECT OF FOLLICLE-STIMULATING HORMONE AND INTERSTITIAL CELL-STIMULATING HORMONE ON SPERMATOGENESIS IN LONG-EVANS RATS HYPOPHYSECTOMIZED FOR SIX MONTHS

Acta Endocrinologica ◽

10.1530/acta.0.0430592 ◽

1963 ◽

Vol 43 (4) ◽

pp. 592-600 ◽

Cited By ~ 32

Author(s):

Ardis J. Lostroh

Keyword(s):

Germ Cell ◽

Pituitary Gland ◽

Germ Cells ◽

Interstitial Cell ◽

Follicle Stimulating Hormone ◽

Primary Spermatocyte ◽

Seminiferous Tubules ◽

Effective Agent ◽

Long Evans ◽

Stimulating Hormone

ABSTRACT The effects of sheep interstitial cell-stimulating hormone (ICSH) and follicle-stimulating hormone (FSH) on spermatogenesis were studied in rats of the Long-Evans strain six months after removal of the pituitary gland. The results confirm the contention that sheep ICSH alone is not an effective agent for stimulating repair of the epithelium of the seminiferous tubules of the rat, and that preparations of sheep FSH contain a principle which, in the presence of less than 1 μg of ICSH per day, can stimulate substantial repair. All the effects obtained with gonadotrophin preparations can be accomodated if one assumes that FSH is specifically concerned with some critical step in the evolution of the primary spermatocyte and that androgen is responsible for maintaining a favorable intratubular environment in which the germ cells can develop. A complication encountered in this study was an unexpected variation in the germ cell population of rats that had been hypophysectomized for a period of 6 months; the possibility that residual gonadotrophin may account for this observation is discussed.

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