Changes in lipid peroxidation and free radical scavengers in the brain of hyper- and hypothyroid aged rats

1995 ◽  
Vol 147 (2) ◽  
pp. 361-365 ◽  
Author(s):  
T Mano ◽  
R Sinohara ◽  
Y Sawai ◽  
N Oda ◽  
Y Nishida ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
Thiobarbituric Acid ◽  
Free Radical Scavengers ◽  
Aged Rats ◽  
Radical Scavengers ◽  
Old Rats ◽  
The Brain

Abstract To determine how lipid peroxides and free radical scavengers are changed in the brain of hyper- or hypothyroid rats, we examined the behavior of lipid peroxide and free radical scavengers in the cerebral cortex of aged (1·5 years old) rats that had been made hyper- or hypothyroid by the administration of thyroxine or methimazol for 4 weeks. Concentrations of catalase, Mn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased in hyperthyroid rats compared with euthyroid rats. Concentrations of total SOD, Cu,Zn-SOD and GSH-PX were increased but that of Mn-SOD was decreased in hypothyroid animals. There were no differences among hyperthyroid, hypothyroid and euthyroid rats in the levels of coenzymes 9 or 10. The concentration of lipid peroxides, determined indirectly by the measurement of thiobarbituric acid reactants, was decreased in hyperthyroid rats but not in hypothyroid rats when compared with euthyroid animals. These findings suggest that free radicals and lipid peroxides are scavenged to compensate for the changes induced by hyper- or hypothyroidism. Journal of Endocrinology (1995) 147, 361–365

scholarly journals Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status

2000 ◽  
Vol 164 (1) ◽  
pp. 97-102 ◽  
Author(s):  
R Shinohara ◽  
T Mano ◽  
A Nagasaka ◽  
R Hayashi ◽  
K Uchimura ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Myocardial Dysfunction ◽  
Lipid Peroxide ◽  
Alpha Tocopherol ◽  
Free Radical Scavengers ◽  
Thyroid Status ◽  
Euthyroid State ◽  
Hyperthyroid State ◽  
Old Rats

Free radicals, hydroxyperoxides and H(2)O(2) are all known to damage cell components. This study was designed to compare the concentrations of hydroxyperoxide and free radical scavengers in the cardiac muscles of old rats in the hyper- or hypothyroid condition, to determine whether rates of peroxidation would differ with age, thyroid status, or both. Rats were rendered hyper- or hypothyroid by administration of l-thyroxine or methimazole for 4 weeks. Among the old rats, the lipid peroxide (LPO) concentrations, measured as thiobarbituric acid (TBA) reactants, were significantly greater in the hyperthyroid than in the euthyroid state and the LPO concentrations measured as TBA+Fe(3+) reactants, which may be precursors of LPO, were significantly greater in the hyperthyroid state, whereas in young rats, the LPO concentrations measured by TBA or TBA+Fe(3+) methods did not differ significantly in the hyperthyroid state. In the euthyroid state, the concentration of LPO measured as TBA+Fe(3+) reactants was significantly reduced with age. Xanthine oxidase (XOD) activity also was markedly increased with age, being more pronounced in the hyperthyroid than in the euthyroid state. The Mn and Cu/Zn superoxide dismutase activities were greater in the hyperthyroid than in the euthyroid state. Glutathione peroxidase activity decreased with age in the euthyroid and, particularly, in the hyperthyroid state. Catalase activity was not affected in the old rats. Concentrations of alpha-tocopherol in the old rats were high in the hyperthyroid state and low in the hypothyroid state, whereas the levels of beta- and gamma-tocopherols in these rats were unchanged in both conditions as compared with the euthyroid state findings. Data suggest that the site of free radical generation differs in older rats, with additional shifts in the location of intracellular lipid peroxidation being noted during hyperthyroidism. Thus, as rats age, the reduction of the free radical scavenger system and the increase in LPO and XOD activities might induce myocardial dysfunction.

Effect of Free Radical Scavengers and Metal Ion Chelators on Hydrogen Peroxide and Phenylhydrazine Induced Red Blood Cell Lipid Peroxidation

1987 ◽  
Vol 3 (1-5) ◽  
pp. 257-263 ◽  
Author(s):  
Hermann Einsele ◽  
Michael R. Clemens ◽  
Ulrike Wegner ◽  
Hans-Dierck Waller
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Free Radical ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Metal Ion ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Cell Lipid ◽  
Metal Ion Chelators

Lipid peroxidation in hepatocyte cell cultures: Modulation by free radical scavengers and iron

1988 ◽  
Vol 24 (2) ◽  
pp. 126-132 ◽  
Author(s):  
G. K. Innes ◽  
B. J. Fuller ◽  
K. E. F. Hobbs
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Cell Cultures ◽  
Free Radical Scavengers ◽  
Radical Scavengers

FREE RADICAL SCAVENGING ACTIVITY OF ACACIA NILOTICA PODS

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 14-22
Author(s):  
T. A Khan ◽  
◽  
A. Gohel
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Acacia Nilotica ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Radical Production ◽  
Medicinal Value

Biomolecules can be oxidized by free radicals. This oxidative damage has an important etiological role in aging and the development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, such as butylated hydroxyl anisole, are good free radical scavengers; however, they can be carcinogenic. Therefore, there is an increasing interest in searching for antioxidants of natural origin. Acacia nilotica has a versatile medicinal value as folk medicine. The present study aims at screening the methanol and aqueous extracts of the pods of Acacia nilotica for antioxidant activity. The effect of these extracts on inhibition of 1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide radicals and of lipid peroxidation was studied. The results indicated that both the extracts exhibited a significant reduction in the DPPH and NO radical production along with a significant reduction in lipid peroxidation. The results indicate the pods of Acacia nilotica to be a cheap and easily available source of antioxidants

Effects of Carbon Tetrachloride on Isolated Rat Liver Cells: Stimulation of Lipid Peroxidation and Inhibitory Action of Free-Radical Scavengers

1978 ◽  
Vol 6 (3) ◽  
pp. 589-591 ◽  
Author(s):  
GIUSEPPE POLI ◽  
MARIA POLI CHIONO ◽  
TREVOR F. SLATER ◽  
MARIO U. DIANZANI ◽  
ENRICO GRAVELA
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Inhibitory Action ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Isolated Rat Liver ◽  
Rat Liver Cells ◽  
Isolated Rat ◽  
Stimulation Of

scholarly journals The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase

2011 ◽  
Vol 30 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Abdellah Ali ◽  
Phalisteen Sultan
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Glutathione Peroxidase ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Hyperthyroid Patients

The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione PeroxidaseThe aim of this study was to determine if lipid peroxidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyperthyroidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 males) were examined in this study. Plasma and erythrocytes malondialdehyde (MDA), erythrocytes glutathione (GSH) and glutathione peroxidase (GSH-PX) were measured. Results show that an increase in lipid peroxidation was observed in the hyperthyroid patients (p < 0.001). This was accompanied by a decrease in glutathione and glutathione peroxidase in the same subjects (p < 0.001). The results suggest that hyperthyroidism has some effects on lipid peroxidation and free radical scavengers.

Changes in Free Radical Scavengers and Lipid Peroxide in Thyroid Glands of Various Thyroid Disorders

1997 ◽  
Vol 29 (07) ◽  
pp. 351-354 ◽  
Author(s):  
T. Mono ◽  
R. Shinohara ◽  
K. Iwase ◽  
M. Kotake ◽  
M. Hamada ◽  
...  
Keyword(s):  
Free Radical ◽  
Lipid Peroxide ◽  
Free Radical Scavengers ◽  
Thyroid Disorders ◽  
Radical Scavengers ◽  
Thyroid Glands

Effects of Urinastatin and Free Radical Scavengers on Hepatic Lipid Peroxidation in Endotoxemia

1996 ◽  
Vol 61 (1) ◽  
pp. 206-214 ◽  
Author(s):  
Tint Htwe ◽  
Masanori Suzuki ◽  
Kiyoaki Ouchi ◽  
Kenji Fukuhara ◽  
Seiki Matsuno
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Hepatic Lipid ◽  
Hepatic Lipid Peroxidation
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