Effect of Free Radical Scavengers and Metal Ion Chelators on Hydrogen Peroxide and Phenylhydrazine Induced Red Blood Cell Lipid Peroxidation

1987 ◽  
Vol 3 (1-5) ◽  
pp. 257-263 ◽  
Author(s):  
Hermann Einsele ◽  
Michael R. Clemens ◽  
Ulrike Wegner ◽  
Hans-Dierck Waller
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Free Radical ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Metal Ion ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Cell Lipid ◽  
Metal Ion Chelators

Changes in lipid peroxidation and free radical scavengers in the brain of hyper- and hypothyroid aged rats

1995 ◽  
Vol 147 (2) ◽  
pp. 361-365 ◽  
Author(s):  
T Mano ◽  
R Sinohara ◽  
Y Sawai ◽  
N Oda ◽  
Y Nishida ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
Thiobarbituric Acid ◽  
Free Radical Scavengers ◽  
Aged Rats ◽  
Radical Scavengers ◽  
Old Rats ◽  
The Brain

Abstract To determine how lipid peroxides and free radical scavengers are changed in the brain of hyper- or hypothyroid rats, we examined the behavior of lipid peroxide and free radical scavengers in the cerebral cortex of aged (1·5 years old) rats that had been made hyper- or hypothyroid by the administration of thyroxine or methimazol for 4 weeks. Concentrations of catalase, Mn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased in hyperthyroid rats compared with euthyroid rats. Concentrations of total SOD, Cu,Zn-SOD and GSH-PX were increased but that of Mn-SOD was decreased in hypothyroid animals. There were no differences among hyperthyroid, hypothyroid and euthyroid rats in the levels of coenzymes 9 or 10. The concentration of lipid peroxides, determined indirectly by the measurement of thiobarbituric acid reactants, was decreased in hyperthyroid rats but not in hypothyroid rats when compared with euthyroid animals. These findings suggest that free radicals and lipid peroxides are scavenged to compensate for the changes induced by hyper- or hypothyroidism. Journal of Endocrinology (1995) 147, 361–365

scholarly journals Signaling of Reactive Oxygen and Nitrogen Species in Diabetes Mellitus

2010 ◽  
Vol 3 (6) ◽  
pp. 361-373 ◽  
Author(s):  
Igor Afanas'ev
Keyword(s):  
Diabetes Mellitus ◽  
Hydrogen Peroxide ◽  
Free Radical ◽  
Reactive Oxygen ◽  
Diabetes Mellitus Type 1 ◽  
Free Radical Scavengers ◽  
Adapter Proteins ◽  
Nitrogen Species ◽  
Radical Scavengers ◽  
Enzymatic Cascades

Disorder of physiological signaling functions of reactive oxygen species(ROS) superoxide and hydrogen peroxide and reactive nitrogen species (RNS) nitric oxide and peroxynitrite is an important feature of diabetes mellitus type 1 and type 2. It is now known that hyperglycemic conditions of cells are associated with the enhanced levels of ROS mainly generated by mitochondria and NADPH oxidase. It has been established that ROS stimulate many enzymatic cascades under normal physiological conditions, but hyperglycemia causes ROS overproduction and the deregulation of ROS signaling pathways initiating the development of diabetes mellitus. On the other hand the deregulation of RNS signaling leads basically to a decrease in NO formation with subsequent damaging disorders. In the present work we will consider the pathological changes of ROS and RNS signaling in enzyme/gene regulated processes catalyzed by protein kinases C and B (Akt/B), phosphatidylinositol 3′-kinase (PI3-kinase), extracellular signal-regulated kinase 1/2 (ERK1/2) and some others. Furthermore we will discuss a particularly important role of several ROS-regulated genes and adapter proteins such as the p66shc, FOXO3a and Sirt2. The effects of low and high ROS levels in diabetes will be also considered. Thus the regulation of damaging ROS levels in diabetes by antioxidants and free radical scavengers must be one of promising treatment of this disease, however, because of the inability of traditionalantioxidative vitamin E and C to interact with superoxide and hydrogen peroxide,new free radical scavengers such as flavonoids, quinones and synthetic mimetics of superoxide dismutase (SOD) should be intensively studied.

FREE RADICAL SCAVENGING ACTIVITY OF ACACIA NILOTICA PODS

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 14-22
Author(s):  
T. A Khan ◽  
◽  
A. Gohel
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Acacia Nilotica ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Radical Production ◽  
Medicinal Value

Biomolecules can be oxidized by free radicals. This oxidative damage has an important etiological role in aging and the development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, such as butylated hydroxyl anisole, are good free radical scavengers; however, they can be carcinogenic. Therefore, there is an increasing interest in searching for antioxidants of natural origin. Acacia nilotica has a versatile medicinal value as folk medicine. The present study aims at screening the methanol and aqueous extracts of the pods of Acacia nilotica for antioxidant activity. The effect of these extracts on inhibition of 1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide radicals and of lipid peroxidation was studied. The results indicated that both the extracts exhibited a significant reduction in the DPPH and NO radical production along with a significant reduction in lipid peroxidation. The results indicate the pods of Acacia nilotica to be a cheap and easily available source of antioxidants

Effect of Ascorbate on Red Blood Cell Lipid Peroxidation

1985 ◽  
Vol 1 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Hermann Einsele ◽  
Michael R. Clemens ◽  
Herbert Remmer
Keyword(s):  
Lipid Peroxidation ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lipid

scholarly journals The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase

2011 ◽  
Vol 30 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Abdellah Ali ◽  
Phalisteen Sultan
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Glutathione Peroxidase ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Hyperthyroid Patients

The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione PeroxidaseThe aim of this study was to determine if lipid peroxidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyperthyroidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 males) were examined in this study. Plasma and erythrocytes malondialdehyde (MDA), erythrocytes glutathione (GSH) and glutathione peroxidase (GSH-PX) were measured. Results show that an increase in lipid peroxidation was observed in the hyperthyroid patients (p < 0.001). This was accompanied by a decrease in glutathione and glutathione peroxidase in the same subjects (p < 0.001). The results suggest that hyperthyroidism has some effects on lipid peroxidation and free radical scavengers.

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