scholarly journals Effect of atrial natriuretic peptide on renal and vascular permeability in diabetes mellitus.

1995 ◽  
Vol 5 (12) ◽  
pp. 2057-2066
Author(s):  
R Zietse ◽  
F H Derkx ◽  
W Weimar ◽  
M A Schalekamp
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Immunoglobulin G ◽  
Insulin Dependent Diabetes Mellitus ◽  
Diabetic Group ◽  
Dependent Diabetes Mellitus ◽  
Hydraulic Permeability ◽  
Filtration Barrier ◽  
Atrial Natriuretic

Synthetic human atrial natriuretic peptide (ANP) (102-126) 0.01 microgram/kg per minute or vehicle was intravenously infused for 2 h in 10 patients with insulin-dependent diabetes mellitus and microalbuminuria (albumin excretion, 20 to 200 micrograms/min) and in 10 healthy subjects. In the diabetic group, the immunoglobulin G clearance was higher, but both size index and charge index as calculated from albumin and immunoglobulin clearances were equal compared with normal values. The fractional clearances of small dextrans (< 3.6 nm) were lower in diabetics, which was compatible with a depressed hydraulic permeability (Kf). During ANP infusion, the excretion of albumin and immunoglobulin G increased in the diabetic subjects (189 +/- 12 to 521 +/- 84 and 7.1 +/- 3.5 to 21 +/- 8.1 micrograms/min, respectively; both P < 0.05) only. In the diabetics, the clearance of dextrans > 54 A increased and our calculations indicated an increase in "shut-flow" (omega o). The transcapillary escape rate of albumin, which was elevated in the diabetics at baseline, increased in the diabetic group only. Thus, ANP uncovers altered size selectivity of the filtration barrier in a phase that is otherwise characterized by charge-selective changes only. Moreover, the increased susceptibility of the glomerular capillaries in diabetics to ANP seems to be part of a more generalized capillary abnormality, because ANP also increases the transcapillary escape of albumin.

Association of a nocturnal rise in plasma α-atrial natriuretic peptide and reversed diurnal blood pressure rhythm in hospitalized normotensive subjects with non-insulin dependent diabetes mellitus

1994 ◽  
Vol 131 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Shigeru Nakano ◽  
Kenzo Uchida ◽  
Takashi Ishii ◽  
Mihoko Takeuchi ◽  
Sadahide Azukizawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Insulin Dependent Diabetes Mellitus ◽  
Plasma Aldosterone ◽  
Dependent Diabetes Mellitus ◽  
Diurnal Changes ◽  
Group 2 ◽  
Group 1 ◽  
Atrial Natriuretic

Nakano S, Uchida K, Ishii T, Takeuchi M, Azukizawa S, Kigoshi T, Morimoto S. Association of a nocturnal rise in plasma alpha-atrial natriuretic peptide and reversed diurnal blood pressure rhythm in hospitalized normotensive subjects with non-insulin dependent diabetes mellitus. Eur J Endocrinol 1994;131:184–90. ISSN 0804–4643 Diurnal changes in plasma atrial natriuretic peptide (ANP), plasma renin activity (PRA) and plasma aldosterone as related to those in blood pressure (BP) were studied under hospital conditions in 18 diabetic subjects without proteinuria and 8 age-matched control subjects. Of 18 diabetic subjects, 10 had a normal diurnal BP rhythm with the peak value in the afternoon (group 1) and 8 had a reversed BP rhythm with the peak value during the night (group 2). Autonomic dysfunction estimated by measuring orthostatic BP and heart-rate changes and beat-to-beat heart-rate variations was more pronounced in group 2 than in group 1. Fasting plasma glucose and HbA1c were similarly high in both diabetic groups. Group 1 showed modestly elevated mean 24-h MBP and plasma ANP levels, modestly low mean 24-h PRA and plasma aldosterone levels, and a lack of diurnal ANP changes similar to that in controls. Group 2 showed markedly elevated mean 24-h BP and plasma ANP levels, markedly low mean 24-h PRA and plasma aldosterone levels, and nocturnal rises in plasma ANP and BP. PRA and plasma aldosterone exhibited circadian rhythms with their peak values found in the early morning in all three groups. The daytime/overnight excretion ratios of sodium and water were normal in group 1 and low in group 2. These results indicate that diurnal changes in plasma ANP, PRA and plasma aldosterone are altered in diabetic subjects with normal and reversed diurnal BP rhythms, predominantly in the latter. Shigeru Nakano, Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-02, Japan

scholarly journals Effects of insulin on plasma renin activity, plasma atrial natriuretic peptide and gody fluid volume in diabetes mellitus.

1990 ◽  
Vol 31 (5) ◽  
pp. 671-682 ◽  
Author(s):  
Tetsuya NAKAMURA ◽  
Shuichi ICHIKAWA ◽  
Tetsuo SAKAMAKI ◽  
Futao AIZAWA ◽  
Toshiaki KURASHINA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Natriuretic Peptide ◽  
Plasma Renin Activity ◽  
Natriuretic Peptide ◽  
Plasma Renin ◽  
Fluid Volume ◽  
Renin Activity ◽  
Plasma Atrial Natriuretic Peptide ◽  
Atrial Natriuretic

Angiotensin-Converting Enzyme Inhibition Does Not Correct Early Defects in Renal and Vascular Permeability in Diabetes Mellitus

1998 ◽  
Vol 94 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Robert Zietse ◽  
Frans H. Derkx ◽  
Willem Weimar ◽  
Maarten A. Schalekamp
Keyword(s):  
Diabetes Mellitus ◽  
Angiotensin Converting Enzyme ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Enzyme Inhibition ◽  
Barrier Function ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibition ◽  
Atrial Natriuretic

1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy a defect in glomerular barrier function can be demonstrated during infusion of atrial natriuretic peptide. 2. The aim of this study was to investigate whether angiotensin-converting enzyme inhibition could prevent the proteinuric response to atrial natriuretic peptide in these patients. We performed infusions of atrial natriuretic peptide (0.01 μg min−1 kg−1) in 10 patients with insulin-dependent diabetes mellitus and microalbuminuria (urinary albumin excretion 90 ± 44 mg/day), both before and after 1 month of treatment with enalapril (20 mg once daily). 3. Despite a 40% reduction in proteinuria, angiotensin-converting enzyme inhibition did not prevent the atrial natriuretic peptide-induced increase in protein excretion. Both before and during angiotensin-converting enzyme inhibition, atrial natriuretic peptide infusion resulted in a significant increase in the fractional excretion of large dextran molecules, which is compatible with an increase in flow through large unrestrictive ‘shunt' pores. Atrial natriuretic peptide infusion also induced an increase in the transcapillary escape rate of albumin and angiotensin-converting enzyme inhibition also failed to prevent this effect of atrial natriuretic peptide on peripheral capillary permeability. 4. We conclude that angiotensin-converting enzyme inhibition during 1 month does not correct the capillary barrier function defect in patients with diabetes mellitus and microalbuminuria that is unmasked by atrial natriuretic peptide infusion.

Plasma and Urine Concentrations of Atrial Natriuretic Peptide in Patients with Diabetes Mellitus

Pancreas ◽  
1988 ◽  
Vol 3 (4) ◽  
pp. 404-408 ◽  
Author(s):  
Yoshinobu Suzuki ◽  
Hitoshi Suzuki ◽  
Ryusuke Ohtake ◽  
Tokihiko Tsuchiya ◽  
Hiroaki Muramatsu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Patients With Diabetes ◽  
Urine Concentrations ◽  
Atrial Natriuretic
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