Protocol for the Prospective Cohort Study for Varicose Veins Incidence and Natural Course (VINCI)

Abstract Background: It is unknown how long SARS-CoV-2 antibodies persist after COVID-19. The natural course of anti-SARS-CoV-2 antibodies was analyzed in a large post-COVID-19 cohort, until 12 months post-infection. Methods: The total antibodies SARS-CoV-2 (IgM and IgG) were tested in a cohort of patients with different COVID-19 disease severity sampled at 4 timepoints up to 12 months post COVID-19. In 23 randomly selected patients, the antibody isotypes: anti-spike IgM, IgA and IgG and anti-nucleocapsid IgG were analysed. Results: In total 152/153 patients (99%) tested positive for total anti-SARS-CoV-2 after 12 months of COVID-19; 3 patients tested positive at 8 to 10 months post infection just before vaccination. The SARS-CoV-2 antibody subclasses anti-nucleocapsid IgG, anti-spike IgG and IgA were all still detectable after 12 months. Anti-spike IgM waned after 12 months in the majority of patients.Conclusion: IgG and IgA antibodies against SARS-CoV-2 persisted 12 months post-COVID-19.

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Natural course of nonalcoholic fatty liver disease in southern China: A prospective cohort study

Journal of Digestive Diseases ◽

10.1111/j.1751-2980.2011.00571.x ◽

2012 ◽

Vol 13 (3) ◽

pp. 153-160 ◽

Cited By ~ 47

Author(s):

Yong Jian ZHOU ◽

Yu Yuan LI ◽

Yu Qiang NIE ◽

Chun Ming HUANG ◽

Chuang Yu CAO

Keyword(s):

Cohort Study ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Fatty Liver Disease ◽

Southern China ◽

Natural Course ◽

Nonalcoholic Fatty Liver

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Preliminary Results of PTFE Patch Saphenoplasty to Prevent Neovascularization Leading to Recurrent Varicose Veins

Phlebology The Journal of Venous Disease ◽

10.1177/026835559801300103 ◽

1998 ◽

Vol 13 (1) ◽

pp. 10-13 ◽

Cited By ~ 32

Author(s):

J. J. Earnshaw ◽

B. Davies ◽

K. Harradine ◽

B. P. Heather

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Varicose Vein ◽

Prospective Cohort ◽

Varicose Veins ◽

Varicose Vein Surgery ◽

Barrier Methods ◽

Duplex Imaging ◽

Surgical Unit ◽

Perforating Vein

Objective: Recurrence is common after varicose vein surgery. Neovascularization may be one cause of recurrent veins. This was a study of PTFE patch saphenoplasty to try and prevent recurrent veins. Design and setting: Prospective cohort study of patients treated in a vascular surgical unit. Patients and interventions: Fifty patients having surgery for symptomatic long saphenous varicose veins (66 legs, 51 primary and 15 recurrent veins) had a PTFE patch sutured over the saphenous opening after flush saphenofemoral ligation. Main outcome measures: The rate of varicose vein recurrence and neovascularization 1 year after surgery were determined using clinical examination and venous duplex imaging. Results: Forty patients (80%) remained pleased with the results of their surgery. Recurrent veins were visible in 14 (21%) legs: 10 were principally due to neovascularization, two to sapheno-popliteal incompetence and two to an incompetent mid-thigh perforating vein. Three other legs had neovascularization but no recurrent veins. Both recurrent veins (47% versus 14%) and neovascularization (40% versus 14%) were significantly more common in patients having surgery for recurrent veins. Conclusions: PTFE patching was safe but did not abolish neovascularization. Neovascularization was the principal cause of recurrent veins in this study and perseverance with investigations into other barrier methods is worthwhile.

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