scholarly journals Myeloproliferative masks of multiple myeloma: A review of literature and clinical case reports

2017 ◽  
Vol 89 (1) ◽  
pp. 72-77
Author(s):  
V V Ryzhko ◽  
A E Grachev ◽  
A A Klodzinsky ◽  
T V Ivanova ◽  
M S Sataeva ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Therapeutic Strategy ◽  
Case Reports ◽  
Myeloproliferative Disorders ◽  
Molecular Testing ◽  
Review Of Literature ◽  
First Case ◽  
Aggressive Tumor

Concurrences of multiple myeloma with myeloproliferative diseases or secondary myeloid leukemoid reactions are rather rare. The paper describes 3 cases of multiple myeloma: the first case concurrent with neutrophilic leukocytosis; the second case with secondary erythropoetin-dependent erythrocytosis, and the third case with chronic myeloid leukemia. In such cases, an accurate diagnosis requires molecular testing, besides routine clinical and laboratory studies. The paper discusses therapeutic strategy in cases of a concurrence of 2 competing tumors of the blood system: to treat them simultaneously or the most aggressive tumor now, as well as a relationship between multiple myeloma and chronic myeloid leukemia, other myeloproliferative disorders, and secondary myeloid leukemoid reactions.

Case reports of chronic myeloid leukemia and tuberculosis: Is imatinib the link between the two?

2020 ◽  
Author(s):  
Shailendra Prasad verma ◽  
Anil Kumar Tripathi ◽  
Nidhish Kumar ◽  
Suneel Kumar Gupta
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Case Reports

scholarly journals An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Kosuke Miki ◽  
Naoshi Obara ◽  
Kenichi Makishima ◽  
Tatsuhiro Sakamoto ◽  
Manabu Kusakabe ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Plasma Cells ◽  
Bone Marrow Examination ◽  
Bone Lesions ◽  
Dexamethasone Treatment ◽  
Lytic Bone Lesions

We report the case of a 76-year-old man who was diagnosed as having chronic myeloid leukemia (CML) with p190 BCR-ABL while receiving treatment for symptomatic multiple myeloma (MM). The diagnosis of MM was based on the presence of serum M-protein, abnormal plasma cells in the bone marrow, and lytic bone lesions. The patient achieved a partial response to lenalidomide and dexamethasone treatment. However, 2 years after the diagnosis of MM, the patient developed leukocytosis with granulocytosis, anemia, and thrombocytopenia. Bone marrow examination revealed Philadelphia chromosomes and chimeric p190 BCR-ABL mRNA. Fluorescence in situ hybridization also revealed BCR-ABL-positive neutrophils in the peripheral blood, which suggested the emergence of CML with p190 BCR-ABL. The codevelopment of MM and CML is very rare, and this is the first report describing p190 BCR-ABL-type CML coexisting with MM. Moreover, we have reviewed the literature regarding the coexistence of these diseases.

scholarly journals Concurrent Diagnosis of Chronic Myeloid Leukemia and Follicular Lymphoma: An Unreported Presentation

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Amy G. Starr ◽  
Sushma R. Jonna ◽  
Joeffrey J. Chahine ◽  
Bhaskar V. Kallakury ◽  
Chaitra S. Ujjani
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Follicular Lymphoma ◽  
Myeloid Leukemia ◽  
Chronic Phase ◽  
Mediastinal Lymphadenopathy ◽  
Pcr Analysis ◽  
Molecular Testing ◽  
Fish Analysis ◽  
Rt Pcr ◽  
Non Hodgkin Lymphoma

Lymphadenopathy in chronic myeloid leukemia (CML) is usually due to extramedullary involvement with accelerated or blast phases of the disease. The occurrence of non-Hodgkin lymphoma (NHL) as a synchronous malignancy with CML is rare. We report a case of a 73-year-old male who presented with dyspnea and right-sided lower extremity edema in the setting of leukocytosis. Bone marrow evaluation indicated a chronic phase chronic myeloid leukemia (CML), confirmed by molecular testing. Imaging of the chest for persistent dyspnea revealed supraclavicular and mediastinal lymphadenopathy. Biopsy of the cervical node showed expanded lymphoid follicles with atypical germinal centers that were positive for CD10, BCL-2, and BCL-6, consistent with follicular lymphoma (FL). Nodal PCR demonstrated clonal IGH and IGK gene rearrangements, and FISH analysis was positive for IGH-BCL-2 fusion. Together, these tests supported the diagnosis of FL. Additionally, the lymph node showed paracortical expansion by maturing pan-hematopoietic elements, no blastic groups, and positive RT-PCR analysis for BCR-ABL1, indicating concomitant involvement by chronic phase-CML. To our knowledge, this is the first reported case of a patient with a concurrent diagnosis of CML and FL.

Malignant Melanoma of the Glans Penis in a Chronic Myeloid Leukemia Patient after Busulfan Therapy

1987 ◽  
Vol 73 (6) ◽  
pp. 645-648 ◽  
Author(s):  
Giovanni Sparaventi ◽  
Annunziata Manna ◽  
Pietro Muretto ◽  
Carlo Pazzaglia ◽  
Mariangela Palazzi ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Malignant Melanoma ◽  
Myeloid Leukemia ◽  
Immune Status ◽  
Case Reports ◽  
Alkylating Agents ◽  
Chronic Myeloid Leukemia Patient ◽  
Glans Penis ◽  
Secondary Neoplasms ◽  
Secondary Neoplasm

There are many case reports of secondary neoplasms occurring after treatment with alkylating agents. A case of malignant melanoma of the glans penis in a chronic myeloid leukemia (CML) Ph'-positive patient after 13 years on busulfan treatment is described. Since neither impairment of immune status nor increased incidence of secondary neoplasm have hitherto been reported in CML, the suggestion that busulfan has a carcinogenetic effect is discussed.

Sign in / Sign up

Export Citation Format

Share Document