Latent Autoimmune Diabetes in Adults (LADA) in Recent Clinical Practice

2019 ◽  
Vol 5 (1) ◽  
pp. e4-e6
Author(s):  
Hiroshi Bando ◽  
Keyword(s):  
Clinical Practice ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes

Abstract #265 Clinical Characteristic of 31 Patients Diagnosed with Latent Autoimmune Diabetes in Adults (Lada) in a Multicentric Study in Mexico

2019 ◽  
Vol 25 ◽  
pp. 103
Author(s):  
Raquel Faradji ◽  
Carmen Castillo-Galindo ◽  
Natalia De la Garza-Hernandez ◽  
Sigfrido Miracle-Lopez ◽  
Claudia Ramirez-Renteria ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Multicentric Study ◽  
Latent Autoimmune Diabetes ◽  
Clinical Characteristic

Abstract #235: Prevalence and Characteristics of Latent Autoimmune Diabetes in Adults (LADA) in a Region of India

2017 ◽  
Vol 23 ◽  
pp. 48
Author(s):  
Alok Kumar ◽  
Alberto De Leiva
Keyword(s):  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes

Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes

2019 ◽  
Vol 15 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Elin Pettersen Sørgjerd
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Adult Onset ◽  
Latent Autoimmune Diabetes ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Being multiple autoantibody positive have also shown to be more common in childhood diabetes compared to adult onset diabetes, and multiple autoantibody positivity have a high predictive value of childhood type 1 diabetes. Autoantibodies have shown inconsistent results to predict diabetes in adults. Levels of autoantibodies are reported to cause heterogeneity in LADA. Reports indicate that individuals with high levels of autoantibodies have a more type 1 diabetes like phenotype and individuals with low levels of autoantibody positivity have a more type 2 diabetes like phenotype. It is also well known that autoantibody levels can fluctuate and transient autoantibody positivity in adult onset autoimmune diabetes have been reported to affect the phenotype.

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

2019 ◽  
Vol 15 (3) ◽  
pp. 172-173 ◽  
Author(s):  
Valdemar Grill ◽  
Bjørn O. Åsvold
Keyword(s):  
Genetic Background ◽  
Clinical Utility ◽  
Autoimmune Diabetes ◽  
Classical Type ◽  
Phenotypic Characteristics ◽  
Latent Autoimmune Diabetes ◽  
The Impact

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

scholarly journals ELISA based on peptide antigens reproducing cross-reactive viral epitopes to detect antibodies in Latent Autoimmune Diabetes in Adults vs. Type 1 Diabetes

MethodsX ◽  
2021 ◽  
pp. 101452
Author(s):  
Feliciana Real-Fernández ◽  
Alessandra Gallo ◽  
Francesca Nuti ◽  
Lorenzo Altamore ◽  
Gloria Giovanna Del Vescovo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Peptide Antigens ◽  
Latent Autoimmune Diabetes

Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human Glutamic Acid Decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes

2021 ◽  
Author(s):  
Feliciana Real-Fernández ◽  
Alessandra Gallo ◽  
Francesca Nuti ◽  
Lorenzo Altamore ◽  
Gloria Giovanna Del Vescovo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Peptide Epitopes ◽  
Latent Autoimmune Diabetes

Chronic complications and mortality in community-based patients with latent autoimmune diabetes in adults: the Fremantle Diabetes Study

2008 ◽  
Vol 25 (10) ◽  
pp. 1245-1250 ◽  
Author(s):  
P. Myhill ◽  
W. A. Davis ◽  
D. G. Bruce ◽  
I. R. Mackay ◽  
P. Zimmet ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Chronic Complications ◽  
Community Based ◽  
Latent Autoimmune Diabetes ◽  
Complications And Mortality
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