congenital rubella
Recently Published Documents


TOTAL DOCUMENTS

992
(FIVE YEARS 113)

H-INDEX

46
(FIVE YEARS 3)

2021 ◽  
Vol 14 (4) ◽  
pp. 1719-1723
Author(s):  
Natarajan Muninathan

Rubella causes a mild self‑limiting illness in children with fever and rash, however in pregnant women, rubella infection causes miscarriage, fetal death, or an infant born with congenital birth defects known as congenital rubella syndrome. The present study attempts to investigate the seroprevalence of IgG rubella antibodies in Indian adolescent girls. The study being a cross -sectional hospital based, was carried at the department of Obstetrics and Gynecology OPD and ward at Meenakshi Medical College Hospital and Research Institute (MMCHRI), Enathur, Kanchipuram, Tamil Nadu, India. In all the cases the association was statistically not significant (P value>0.05) when compared with joint family. The odds of Rubella IgG positive was 0.656 times in nuclear family and the association was statistically not significant (P value>0.05) when compared with several children in three. The odds of Rubella IgG positive were 1.711 times in only 1 child, the odds of Rubella IgG positive in 2 children were 1.371 times. In the present study we conclude that the statistically no significant association between the socioeconomic status, parents’ age, father’s education level, father’s employment status, mother’s education level, mother’s employment status, and Rubella IgG status.


Author(s):  
Samileh Noorbakhsh ◽  
Mohammad Vafaee-Shahi ◽  
Leila Tahernia ◽  
Sarvenaz Ashouri ◽  
Aina Riahi

Background: A safe and effective rubella vaccine is available and prescribed in IRAN. Objective: This is a survey of CRS cases collected based on WHO criteria one decade after MR vaccination campaign (2003) Methods: This Multi-stage prospective/cross-sectional study was carried out in three stages in 3 educational hospitals in Tehran (Rasoul Aram, Akbar Abadi and Firoozabadi), In the first stage of study between 2011 and 2012 total 186 infants were evaluated and in the second stage of study, total 163 blood samples of infants with suspected INTRA UTERINE INFECTION were compared with a group of healthy matched infants. In the first and second stages, Rubella immunity (IgG&IgM) in cord blood was evaluated by Eliza method. Results: Despite MR vaccination in Iran, after one decade"confirmed CRS" and " compatible CRS" were diagnosed in 5 and 31 from 89 CRS suspected cases. Conclusion: The incidence of "confirmed CRS" in every 100 CRS suspected infants (after campaign) is 5.6 %;and 31 CRS Compatible cases are so important. Without active CRS surveillance, mild infection such as IUGR, hearing loss,heart abnormalities, impaired vision, and mental retardation even in the developed country might be missed. Fetal infection is persistent, which imposes additional costs on the country.Another mass vaccination in women and girls is needed. Also, the anti-rubella IgG testing before pregnancy in women who were not vaccinated; vaccination of women before marriage /pregnancy should be obligatory in order to prevent the CRS.


Author(s):  
Heather Battles ◽  
Rebecca Gilmour

Epidemics and pandemics are typically discussed in terms of morbidity and mortality, susceptibility and immunity, and social responses to and impacts of the immediate epidemic event. Much less attention is paid to the longer-term consequences for individuals and populations in terms of the sequelae of infections, such as blindness after smallpox, deafness due to congenital rubella, and paralysis after polio. This same tendency is observed in the COVID-19 pandemic, with counts of cases and deaths, questions of immunity, and economic impacts at the foreground and long-term or chronic health impairment of COVID-19 survivors receiving less attention. Much of the existing research on the effects of such disease sequelae has come from disability history; in addition, the bioarchaeology of impairment/disability is an emerging area of research that can contribute insight into experiences of disease consequences. In this article, we give an overview of published work on survivors of infectious disease using both bioarchaeology and disability history. Using the example of post-polio paralysis, we propose a theoretical approach to the bioarchaeological study of infectious disease that is inclusive of the history of impairment and disability, which we refer to as a survivor lens. We structure this discussion through scaffolded questions that move through multiple levels of analysis: from the individual and relational to the drivers of cultural change. We argue that bioarchaeological research on past epidemics and pandemics that attends to morbidity and lasting impairment and disability can contribute to wider conversations about infectious disease and disability in the past and present.   En général, les épidémies et les pandémies sont considérées en termes de morbidité et de mortalité, de susceptibilité et d’immunité, et de réponses sociales et d’impacts immédiats de l’événement épidémique. Moins d’attention est accordée aux conséquences à long terme pour les individus et les populations en termes de séquelles d’infections, telles que la cécité après la variole, la surdité due à la rubéole congénitale et la paralysie après la polio. Cette même tendance est observée lors de la pandémie de COVID-19. Il y a moins d’attention accordée au nombre de cas et de décès, aux questions d’immunité et d’impacts économiques au premier plan, et aux problèmes de santé à long terme ou chroniques des survivants de COVID-19 reçoivent. Une grande partie de la recherche existante sur les effets de ces séquelles de la maladie provient de la recherche sur les déficiences/handicaps. De plus, la bioarchéologie de la déficience/handicap est un domaine de recherche émergent qui peut contribuer à mieux comprendre les expériences des conséquences de maladie. Dans cet article, nous donnons un aperçu des travaux publiés sur les survivants de maladies infectieuses en utilisant à la fois la bioarchéologie et l’histoire du handicap. En utilisant l’exemple de la paralysie post-polio, nous proposons une approche théorique de l’étude bioarchéologique des maladies infectieuses qui inclut l’histoire de la déficience/handicap, que nous appelons une lentille de survivant. Nous structurons cette discussion à travers des questions échafaudées qui traversent de multiples niveaux d’analyse: de l’individu au relationnel, jusqu’au aux changements culturels. Nous soutenons que la recherche bioarchéologique sur les épidémies et pandémies historiques qui examine la morbidité et le handicap peut contribuer à des conversations plus larges sur les maladies infectieuses et le handicap au passé ainsi qu’au présent.


Author(s):  
Christopher S. Langlo ◽  
Alana Trotter ◽  
Honey V. Reddi ◽  
Kala F. Schilter ◽  
Rebecca C. Tyler ◽  
...  

Author(s):  
Sushmita Kaushik ◽  
Sandeep Choudhary ◽  
Deepika Dhingra ◽  
Mini P. Singh ◽  
Gaurav Gupta ◽  
...  

2021 ◽  
Vol 15 (11) ◽  
pp. 3166-3167
Author(s):  
Muhammad Sohail Tareen ◽  
Maryam Shoaib ◽  
Uzma Afridi ◽  
Samia Saifullah

Background: Rubella is major cause of neonatal abnormalities and miscarriages on worldwide level. Objective: To find the incidence of rubella in congenital births by assessing antibodies against rubella. Study Design: Cross sectional study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta 1st April 2019 to 31st March 2021. Methodology: Four hundred pregnant women were analyzed for their IgG and IgM levels. A complete socioeconomic, demographics and clinical information was recorded on a well designed questionnaire. Results: The mean age of pregnant women was 24.5±4.1 years. Majority of women were between 35-40 years. High IgG were seen in all patients compared with IgM. The seropositivity for IgG increased with increasing age. Conclusion: The total reported IgG positive cases were up to 16% while of IgM were 3%. Keywords: Rubella, Pregnancy, Birth defects


2021 ◽  
Author(s):  
Andrea C. Carcelen ◽  
Amy K. Winter ◽  
William J. Moss ◽  
Innocent Chilumba ◽  
Irene Mutale ◽  
...  

Abstract Background: High-quality, representative serological surveys allow direct estimates of immunity profiles to inform vaccination strategies but can be costly and logistically challenging. Leveraging residual serum samples is one way to increase their feasibility.Methods: We subsampled 9,854 residual sera from a 2016 national HIV survey in Zambia and tested these specimens for anti-measles and anti-rubella virus IgG antibodies using indirect enzyme immunoassays. We demonstrate innovative methods for sampling residual sera and analyzing seroprevalence data, as well as the value of seroprevalence estimates to understand and control measles and rubella. Results: National measles and rubella seroprevalence for individuals younger than 50 years was 82·8% (95% CI 81·6, 83·9%) and 74·9% (95% CI 73·7%, 76·0%), respectively. Despite a successful childhood vaccination program, measles immunity gaps persisted across age groups and districts, indicating the need for additional activities to complement routine immunization. Prior to vaccine introduction, we estimated a rubella burden of 96 congenital rubella syndrome cases per 100,000 live births.Conclusion: Residual samples from large-scale surveys can reduce the cost and challenges of conducting serosurveys, and multiple pathogens can be tested. Procedures to access specimen quality, ensure ethical approvals, and link sociodemographic data can improve the timeliness and value of results.


2021 ◽  
Vol 47 (11) ◽  
pp. 476-478
Author(s):  
Myriam Saboui ◽  
Joanne Hiebert ◽  
Susan G Squires ◽  
Mireille Guay ◽  
Patricia Barcellos ◽  
...  

Elimination, in the context of measles, rubella and congenital rubella syndrome (CRS), refers to the absence of endemic measles/rubella virus transmission in a region or other defined geographic area for at least 12 months, in the presence of a high-quality surveillance system that meets targets of key performance indicators. In 1994, Canada and other countries of the World Health Organization (WHO) region of the Americas committed to the objectives of measles elimination by 2000 and rubella and CRS by 2010. Canada met these targets: eliminating measles transmission in 1998; rubella transmission in 2005; and endemically-acquired CRS in 2000. The WHO region of Americas was declared free of endemic rubella/CRS in 2015 and endemic measles in 2016. At the request of the Pan American Health Organization (PAHO), Canada’s elimination status of measles, rubella and CRS was verified in 2012 and again in 2017. Prior to submission to PAHO, the verification reports were reviewed, approved and endorsed by Canada’s National Certification Committee (NCC). The NCC is a group of experts who are not directly involved with the management of vaccine preventable diseases or immunization program implementation at the national level, but who have the expertise to assist in ensuring that Canada is meeting PAHO’S goals of elimination and eradication. Members are responsible for reviewing Canada’s current mechanisms of surveillance and progress towards elimination of targeted vaccine preventable diseases in Canada. Members have expertise in the fields of public health, infectious diseases and/or laboratory sciences.


2021 ◽  
Author(s):  
Heikki Peltola

Rubella is caused by an RNA virus. Infection results mostly in few or no symptoms. Viremia and viral shedding start before a rash may be seen. German physicians were probably the first to describe rubella in the early 19th century, hence the name "German measles". A British physician reported an outbreak in a boys’ school in India in 1841. He used the word rubella, "little red", a Latin diminutive from ruber (red). Rubella is often indistinguishable from other viral exanthematous diseases, but palpable posterior auricular and suboccipital lymph nodes are almost pathognomonic. Rubella infection during pregnancy may result in cataract, heart disease and deafness in an infant, forming the key triad defining “congenital rubella syndrome”, CRS. Also, mental retardation is common. After birth, rubella is a mild disease with rare complications only. There is no treatment for rubella or CRS, but vaccination programs usually with MMR-vaccine maintaining high vaccine uptake over time can virtually eliminate rubella.


2021 ◽  
Vol 45 ◽  
Author(s):  
Suzy M Teutsch ◽  
Carlos A Nunez ◽  
Anne Morris ◽  
Guy D Eslick ◽  
Gulam Khandaker ◽  
...  

For 27 years, national prospective data on selected rare childhood diseases have been collected monthly by the Australian Paediatric Surveillance Unit (APSU) from paediatricians and other clinical specialists who report cases in children aged up to 16 years. We report here the annual results of APSU surveillance in 2020 for ten rare communicable diseases and complications of communicable diseases, namely: acute flaccid paralysis (AFP); congenital cytomegalovirus (CMV) infection; neonatal herpes simplex virus (HSV) infection; perinatal exposure to human immunodeficiency virus (HIV); paediatric HIV infection; severe complications of seasonal influenza; juvenile onset recurrent respiratory papillomatosis (JoRRP); congenital rubella syndrome; congenital varicella syndrome; and neonatal varicella infection. We describe the results for each disease in the context of the total period of study, including demographics, clinical characteristics, treatment and short-term outcomes. Despite challenges presented by the coronavirus disease 2019 (COVID-19) pandemic in 2020, more than 1,400 paediatricians reported regularly to the APSU and an overall monthly reporting rate of > 90% was achieved. The minimum AFP target of 1 case per 100,000 children aged less than 15 years was achieved and there were few cases of vaccine-preventable diseases (JoRRP, rubella, varicella). However, high cases of congenital CMV, neonatal HSV and perinatal exposure to HIV persist. There were no severe complications of seasonal influenza reported for the first time in 13 years. This is consistent with other surveillance data reporting a decline of influenza and other communicable diseases in 2020, and likely reflects the wider effects of public health measures to reduce transmission of SARS-CoV-2 in the Australian community.


Sign in / Sign up

Export Citation Format

Share Document