scholarly journals Effects of dietary nucleotides and cationic peptides on vaccination response in cats

2021 ◽  
Vol 66 (No. 1) ◽  
pp. 17-23
Author(s):  
B Vojtek ◽  
J Mojzisova ◽  
L Kulichova ◽  
P Smrco ◽  
M Drazovska
Keyword(s):  
Antibody Response ◽  
Rapid Onset ◽  
Feline Calicivirus ◽  
Cationic Peptides ◽  
Feline Panleukopenia Virus ◽  
Dietary Nucleotides ◽  
Feline Herpesvirus ◽  
Group A ◽  
Herpesvirus 1 ◽  
Positive Effect

Modulation of the immune system through nutrition is the aim of many studies. As the induction of a rapid onset of immunity in cats is often critical, the objective of this study was to evaluate the effects of orally administered dietary nucleotides and cationic peptides, on the vaccination response in cats. The cats were allocated to two groups: Group A (n = 8) was fed a diet with dietary nucleotides and cationic peptides for ninety-two days, and Group C (n = 8) was fed a diet without the nucleotides and cationic peptides. The cats were vaccinated against feline herpesvirus 1 (FHV-1), feline calicivirus (FCV) and feline panleukopenia virus (FPV). The proliferation activity of lymphocytes and antibody response after vaccination were evaluated using ELISA kits. Comparing the two groups, a significant increase in the proliferation activity of the lymphocytes (P < 0.01) was observed in Group A, as well as a significant increase in the antibody titres after vaccination against feline herpesvirus (P < 0.05; P < 0.001), feline calicivirus (P < 0.01; P < 0.001) and feline panleukopenia virus (P < 0.01; P < 0.001). Protective levels of the antibodies were reached significantly earlier in Group A than in Group C. In conclusion, dietary nucleotides and cationic peptides have a positive effect on the lymphocyte proliferation and antibody production after vaccination against FHV-1, FCV and FPV in cats. Therefore, we assume that they can be used as a suitable immunostimulatory substance in feline practice.

Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydophila felis and Mycoplasma felis DNA and associated risk factors in cats in Spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis

2016 ◽  
Vol 19 (4) ◽  
pp. 461-469 ◽  
Author(s):  
Mireia Fernandez ◽  
Edgar G Manzanilla ◽  
Albert Lloret ◽  
Marta León ◽  
Jean-Christophe Thibault
Keyword(s):  
Risk Factors ◽  
Respiratory Tract ◽  
Feline Calicivirus ◽  
Upper Respiratory Tract ◽  
Respiratory Tract Disease ◽  
Feline Herpesvirus ◽  
Upper Respiratory ◽  
Herpesvirus 1 ◽  
Tract Disease ◽  
Clinical Conditions

Objectives Our objective was to perform the first multicentric study in Spain to evaluate the prevalence of feline herpesvirus-1 (FHV-1), feline calicivirus (FCV), Chlamydophila felis and Mycoplasma felis in cats with upper respiratory tract disease (URTD), conjunctivitis and/or gingivostomatitis (GS) compared with control cats; and to evaluate risk factors for these clinical conditions. Methods Conjunctival and oropharyngeal swabs were collected and a questionnaire regarding signalment, lifestyle, vaccination history and clinical signs was obtained for each cat. Swabs were tested for each pathogen by real-time PCR. Results The study population consisted of 358 cats, including 98 control cats. Among the 260 diseased cats, 127 cats presented with URTD, 149 cats had conjunctivitis, 154 cats were suffering GS; many cats presented more than one clinical condition. The prevalence observed of FHV-1, FCV, C felis and M felis was, respectively, 28.3%, 48.0%, 20.5% and 46.5% in cats with URTD; 24.2%, 43.6%, 19.5% and 38.3% in cats with conjunctivitis; and 15.6%, 58.4%, 9.1% and 37.7% in cats with GS. Prevalences in the control group were 6.1%, 15.3%, 2.0% and 20.4%, respectively. Coinfections were common among all groups of cats. Risk factors were identified for all groups. FHV-1, FCV and C felis were associated with URTD and conjunctivitis. FCV was strongly associated with GS. M felis was present in a high percentage of the population in all groups, but its role in these clinical conditions remains uncertain. Vaccination was protective for URTD and GS but not for conjunctivitis. Conclusions and relevance This epidemiological study describes, for the first time, prevalence for FHV-1, FCV, C felis and M felis in Spain. In general, the prevalences found are similar to those reported in other countries. Factors associated with disease expression were also identified, which are relevant for practitioners.

Therapie des akuten viralen Katzenschnupfens

2019 ◽  
Vol 47 (02) ◽  
pp. 98-109
Author(s):  
Michèle Bergmann ◽  
Anne Ballin ◽  
Bianka Schulz ◽  
René Dörfelt ◽  
Katrin Hartmann
Keyword(s):  
Feline Calicivirus ◽  
Symptomatische Therapie ◽  
Feline Herpesvirus ◽  
Herpesvirus 1

ZusammenfassungDie Haupterreger des Katzenschnupfens, das feline Herpesvirus-1 (FHV-1) und das feline Calicivirus (FCV), sind in Katzenpopulationen weit verbreitet, vor allem in Haushalten mit vielen Katzen auf engem Raum. Katzen mit schweren klinischen Symptomen müssen meist stationär behandelt werden. Eine intensive symptomatische Therapie wirkt sich positiv auf den Heilungsverlauf aus. Der Einsatz antiviraler Medikamente bei Katzen ist limitiert, da viele der Substanzen unwirksam oder bei systemischer Gabe toxisch sind. Antivirale Medikamente werden daher vor allem lokal zur Therapie FHV-1-assoziierter Augenveränderungen eingesetzt. Famciclovir ist jedoch als wirksames Virostatikum zur systemischen Therapie bei Katzen mit FHV-1-bedingten Symptomen geeignet. Gegen FCV sind nur wenige antivirale Medikamente verfügbar. Der Einsatz von Immunglobulinen führte in einer kontrollierten Studie bei Katzen mit FHV-1- und/oder FCV-Infektion zu einer signifikant schnelleren Besserung der Symptome eines akuten Katzenschnupfens.

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