scholarly journals Episiectomy and partial vaginectomy with urethroplasty for excision of vulvar mast cell tumour in a female dog

2021 ◽  
Author(s):  
DL Santos ◽  
JF Chaves ◽  
MP Souto ◽  
GMM Lima ◽  
JS Siqueira ◽  
...  
Keyword(s):  
Mast Cell ◽  
Case Report ◽  
Surgical Treatment ◽  
Surgical Margins ◽  
Cell Tumour ◽  
Ventral Part ◽  
Mast Cell Tumour ◽  
Grade Ii ◽  
Vaginal Canal

This case report describes the surgical treatment of a grade II mast cell tumour in the vulvar region of a 4-year-old female Miniature Pinscher dog. The patient weighed 2 kg, and the tumour measured 2 cm in diameter. The surgery involved an episiotomy, a partial vaginectomy, and a subsequent urethroplasty. Due to the patient’s small size, the surgical margins were set at 2 cm laterally and 2 cm deep, which meant that the entire vulva, as well as the ventral part of the vaginal canal had to be removed. Afterwards, the urethral ostium was elliptically fixed to the skin at the end of the urethroplasty. The follow-up evaluations revealed an excellent recovery without metastasis or recurrence over the following two years.

scholarly journals Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours

2015 ◽  
Vol 59 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Małgorzata Kandefer-Gola ◽  
Janusz A. Madej ◽  
Stanisław Dzimira ◽  
Izabela Janus ◽  
Marcin Nowak ◽  
...  
Keyword(s):  
Mast Cell ◽  
Statistical Analysis ◽  
Endothelial Cell ◽  
Microvessel Density ◽  
Cell Tumour ◽  
Cell Marker ◽  
Mast Cell Tumour ◽  
Endothelial Cell Marker ◽  
Grade Ii ◽  
Grade Iii

AbstractThe aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommended

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

2017 ◽  
Vol 20 (3) ◽  
pp. 455-465 ◽  
Author(s):  
Anna Śmiech ◽  
B. Ślaska ◽  
W. Łopuszyński ◽  
A. Jasik ◽  
M. Szczepanik ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Tumour ◽  
Phenotypic Traits ◽  
Anatomical Location ◽  
Malignancy Grade ◽  
Mast Cell Tumour ◽  
Tumour Location ◽  
Grade Ii ◽  
Statistical Relationships ◽  
Histological Malignancy

Abstract The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs’ age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region. In the group of the oldest dogs aged 11-16, there was higher risk of development of MCTs grade II and III. Young dogs (aged 2-3 and 4-6) were found to be more prone to development of MCTs grade I. There was no correlation between MCTs grade and dogs’ sex and size. To the authors’ knowledge this is the first report on statistical relationships between the degree of mast cell tumour malignancy and dogs’ phenotypic traits, age and tumour location. This analysis indicate predilections for development of the particular mast cell tumour malignancy degrees in certain dog breeds, age, and anatomical location

scholarly journals Successful long-term management with toceranib phosphate of a recurrent muzzle mast cell tumour in a dog

2020 ◽  
Vol 65 (No. 5) ◽  
pp. 227-232
Author(s):  
HE Kim ◽  
JH Kim
Keyword(s):  
Mast Cell ◽  
Lymph Nodes ◽  
Clinical Symptoms ◽  
Cell Tumour ◽  
Mast Cell Tumour ◽  
Mitotic Figures ◽  
Term Management ◽  
Yorkshire Terrier

A 10-year-old spayed female Yorkshire terrier with a muzzle mass was presented. The ulcerated mass was surgically resected, but recurred and grew rapidly over the subsequent 7 months. The submandibular lymph nodes were remarkably enlarged (right: 9.5 × 7.8 cm; left, 4.7 × 4.0 cm). The cytological analysis of the mass and lymph nodes revealed a high-risk mast cell tumour characterised by high mitotic figures (&gt; 5/oil immersion field), nuclear pleomorphism, multi-nucleation, karyomegaly, and anisokaryosis. A polymerase chain reaction analysis targeting the c-kit domain revealed an exon 8 mutation. The resection of the mass was not considered optional because of the location. Oral toceranib (3.25 mg/kg, every other day) and prednisolone (1.0 mg/kg to 0.5 mg/kg, once a day) were administered, and the mass disappeared within 1 month. Subsequently, the toceranib therapy was stopped for 4 months due to neutropenia (0.7 × 10<sup>9</sup>/l). However, the mass recurred and the toceranib was resumed at the original dose, without affecting the neutropenia. No recurrence has been observed at the 16 months’ follow up. Despite the persistent neutropenia, no clinical symptoms have presented. This is another report of the successful treatment of a recurrent muzzle MCT with toceranib in a dog.

scholarly journals Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012)

2013 ◽  
Vol 13 (3) ◽  
pp. 267-280 ◽  
Author(s):  
A. Lejeune ◽  
K. Skorupski ◽  
S. Frazier ◽  
I. Vanhaezebrouck ◽  
R. B. Rebhun ◽  
...  
Keyword(s):  
Mast Cell ◽  
Systemic Chemotherapy ◽  
Local Therapy ◽  
Cell Tumour ◽  
Mast Cell Tumour ◽  
Grade Ii

scholarly journals Prevalence and epidemiological and histopathological features of canine cutaneous mast cell tumours in Uberlândia, Brazil

2017 ◽  
Vol 86 (2) ◽  
pp. 189-193
Author(s):  
Marcelo Carrijo Costa ◽  
Ana Letícia Daher Aprígio Silva ◽  
Thais Almeida Moreira ◽  
Lígia Fernandes Gundim ◽  
Alessandra Aparecida Medeiros-Ronchi
Keyword(s):  
Mast Cell ◽  
Mitotic Index ◽  
Epidemiological Data ◽  
Skin Neoplasms ◽  
Cell Tumour ◽  
Histological Classification ◽  
Mast Cell Tumour ◽  
Grade Ii ◽  
Cutaneous Mast Cell

This study aimed to perform a retrospective survey of canine cutaneous mast cell tumours at the Veterinary Hospital of the Federal University of Uberl‰ndia, as well as to gather epidemiological data, such as breed, age, sex, and location. We also sought to histopathologically classify and characterize the mast cell tumours. Mast cell tumour was the most common neoplasm, accounting for 16.78% of skin neoplasms. In terms of the epidemiological data, the mast cell tumours did not show sexual predilection. Animals aged 9 to 12 years were the most affected (44.14%). The genitalia were the most frequent location (28.15%), and mongrel dogs showed the highest prevalence (30.43%), followed by boxers (22.61%). A total of 92 slides were classified; grade II was most frequently seen (61.96%). Statistically, injuries such as necrosis, oedema, and haemorrhage were not related with histological classification (P > 0.05). Finally, the mitotic index was related to tumour grade (P < 0.05), and can act as an instrument for histological classification of these tumours. Mast cell tumour is the most common neoplasm in dogs, with no sex predilection. Contrary to what was expected, oedema, necrosis and haemorrhage do not increase according to graduation and can be seen in all classifications. Mitotic index is the best indicator to classify these neoplasms.

scholarly journals Clinical and immunohistochemical findings of splenic mast cell tumour in a cat: A case report

2021 ◽  
Vol 66 (No. 11) ◽  
pp. 498-502
Author(s):  
S Lee ◽  
MS Kang ◽  
Y Jeong ◽  
Y Kim ◽  
HH Kwak ◽  
...  
Keyword(s):  
Mast Cell ◽  
Case Report ◽  
Histopathological Examination ◽  
Systemic Mastocytosis ◽  
Clinical Signs ◽  
Cell Tumour ◽  
Mast Cell Tumour ◽  
Appropriate Treatment ◽  
History Of ◽  
Peripheral Blood Smears

A 6-year-old, spayed, female, domestic shorthair cat presented with a 4-month history of chronic intermittent vomiting and anorexia. The haematologic results indicated moderate anaemia and a circulating mast cell population. The abdominal radiography revealed a markedly enlarged spleen. The cytological analysis of the spleen showed a uniform population of mast cells, and a diagnosis of systemic mastocytosis (splenic mast cell tumour with mastocytaemia) was made. This diagnosis was subsequently confirmed by the histopathological examination of the spleen. The immunohistochemistry for KIT showed KIT pattern II (focal cytoplasmic expression). A splenectomy and chemotherapy with vinblastine and prednisolone resulted in remission of the anaemia and other clinical signs. This case report highlights the importance of cytological evaluations of peripheral blood smears and/or aspirates of enlarged spleens for diagnosing splenic mast cell tumours and for quickly initiating the appropriate treatment.

Combined Z-plasty and phalangeal fillet for reconstruction of a large carpal defect following ablative oncologic sur gery

2013 ◽  
Vol 26 (06) ◽  
pp. 510-514 ◽  
Author(s):  
M. G. Renwick ◽  
D. A. Yool ◽  
M. Cantatore
Keyword(s):  
Mast Cell ◽  
Lymph Node ◽  
Preoperative Staging ◽  
Cell Tumour ◽  
Fine Needle Aspirate ◽  
Mast Cell Tumour ◽  
Dorsal Aspect ◽  
Grade Ii ◽  
Large Wound ◽  
Disease Free

SummaryA six-year-old Labrador Retriever was presented for management of a 2 x 2 cm cutaneous mass over the dorsal aspect of the carpus. A fine needle aspirate performed by the referring veterinarian was consistent with a mast cell tumour. The ipsilateral prescapular lymph node was enlarged. Preoperative staging did not reveal any evidence of metastasis. Wide excision of the mass and prescapular lymphadenectomy were performed. The large carpal wound was reconstructed using a combination of Z-plasty and phalangeal fillet using the first digit (dewclaw); about 20% of the original defect was allowed to heal by second intention. Histopathology was consistent with a grade II mast cell tumour with metastatic spread to the lymph node. Vinblastine and prednisolone adjuvant chemotherapy was instituted. Functional and cosmetic outcome were good; only a small 1cm area of alopecia persisted. The dog was disease-free 53 months after surgery. A combination of Z-plasty and a phalangeal fillet using the first digit was a successful treatment to reconstruct a large wound over the dorsal aspect of the carpus in this case.

Sign in / Sign up

Export Citation Format

Share Document