scholarly journals To study the outcome of exchange transfusion in severe neonatal sepsis in neonates admitted in NICU at Dr. Bhim Rao Ambedkar memorial hospital, Raipur, Chhattisgarh, India

2021 ◽  
Vol 8 (3) ◽  
pp. 154-161
Author(s):  
Dr. Badri Narayan Rao ◽  
◽  
Dr. Shashikant Dewangan ◽  
Dr. Vikas Kumar Singh ◽  
◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Exchange Transfusion ◽  
Newborn Infants ◽  
Coagulation System ◽  
Normal Birth ◽  
Medical College ◽  
Blood Exchange ◽  
Blood Exchange Transfusion ◽  
Common Causes ◽  
Reduction Of Mortality

Background: Sepsis is one of the most common causes of neonatal mortality and morbidity.Immaturity of the immune system, newborn infants are highly susceptible to systemic infection.Blood exchange transfusion in severe neonatal sepsis remove bacteria, bacterial toxins, andcirculating pro-inflammatory cytokines, improve perfusion and tissue oxygenation, correct theplasma coagulation system and enhance immunological defence mechanisms. Material andmethods: This is a hospital-based, time-bound, analytical observational study conducted fromJanuary 2019 to December 2019 in the NICU of Dr. B.R.A.M. Hospital & Pt. J. N. M. Medical College,Raipur, Chhattisgarh, India. The data was collected in pre-designed proforma, entered in MicrosoftExcel and analysis was done using SSPS v 22.0. Result: About 42 neonates were diagnosed withsevere neonatal severe. Of which 23 (54.76%) were preterm, 42.24% were term neonates.Maximum 22 (52.38%) were VLBW, 4.76% were LBW and 19.05% were with normal birth weight. Inthe study two-third of 28 (66.67%) were outborn and one third were inborn. In the present studymajority of 30 (71.43%) had EOS and 12 (28.57%) had LOS. In our study out of 42 study subjects24 (57.14%) died and 18 (42.86%) were discharged after blood exchange transfusion. Of those whodied 15 (62.5%) were preterm and of those discharged 10 (55.6%) were term neonates (p=0.349).Outborn neonates more died as compare to inborn though this was also not significant (p=0.133).Conclusion: significant reduction of mortality in patients who underwent exchange transfusion,together with the no adverse effects observed, suggest that this procedure should be considered forthe treatment of neonates with severe sepsis.

scholarly journals Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease

2015 ◽  
Vol 9 ◽  
pp. CMPed.S24909 ◽  
Author(s):  
Mahmoud A. F. Kaabneh ◽  
Ghassan S. A. Salama ◽  
Ayoub G. A. Shakkoury ◽  
Ibrahim M. H. Al-Abdallah ◽  
Afrah Alshamari ◽  
...  
Keyword(s):  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Newborn Infants ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Hemolytic Disease ◽  
Blood Exchange ◽  
Blood Exchange Transfusion ◽  
Group 2 ◽  
Group 1

Objective The objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates. Patients and Method This single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group ( n = 103), and (2) the phototherapy-only group ( n = 97). Infants in group 1 received an oral dose of 2.5 mg/kg phenobarbital every 12 hours for 3 days in addition to phototherapy. The total serum bilirubin was observed. Results Of the total 200 included newborn infants, 186 infants completed the study: 97 infants were included in group 1 and 89 infants in group 2. The difference between the mean total serum bilirubin levels at 24, 48, and 72 hours after starting the trial was clinically and statistically significant at P < 0.05. The differences between the two groups were also statistically significant at P < 0.05. Of the total 186 who completed the study, only 22 underwent blood exchange transfusion [7 from group 1, and 15 from group 2 ( P = 0.0478)]. Conclusion In a limited-resources setting, phenobarbital in combination with phototherapy may be helpful to newborn infants with IHD, as it results in a faster decline in total serum bilirubin, thus decreasing the need for blood exchange transfusion than phototherapy alone.

scholarly journals Study of changes in the blood levels of copper and zinc following the blood exchange transfusion in neonates with hyperbilirubinemia

2016 ◽  
Vol 2 (7) ◽  
pp. 138
Author(s):  
Mehrdad Mirzarahimi ◽  
Afsaneh Enteshari-Moghaddam ◽  
Raheleh Asghari Moghaddam ◽  
Abbas Naghizade ◽  
Mohammad Mazani
Keyword(s):  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Newborn Infants ◽  
Treatment Method ◽  
Blood Levels ◽  
Zn Concentration ◽  
Blood Exchange ◽  
Blood Exchange Transfusion ◽  
Serum Zn ◽  
Before And After

<p class="abstract"><strong>Background:</strong> Blood exchange transfusion (EXT) is an essential treatment method in some icteric newborns and causes some changes in trace elements in them. The effects of blood exchange transfusion on zinc (Zn) and copper (Cu) in newborn infants is unknown. This study was conducted to determine the possible effects of EXT on Zn and Cu by comparing the levels of Zn and Cu in jaundiced neonates.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">In this study, 30 jaundiced term neonates undergoing EXT for the first time, because of idiopathic unconjugated hyperbilirubinemia, were selected. The Zn and Cu levels of 30 blood bank donors’ samples used for EXT were measured and 30 pairs of umbilical cord blood samples were examined for Zn and Cu before and one hour and five days after exchange transfusion. The serum bilirubin concentration was measured before and after EXT. The collected data in laboratory were analysed by statistical methods using SPSS.19. </span></p><p class="abstract"><strong>Results:</strong> In this study 43% were girls and 56.7% were boys and the average age of the infants was 4.56 days at the time of admission. Before EXT, the average of serum bilirubin was 27.74±2.03 mg/dl, and the average of serum Zn was 48.53±4.94 μg/dl that was lower than serum Zn concentration one hour after EXT (55.98±7.60 μg/dl) and five days after EXT (56.63±10.92 μg/dl). This difference was statistically significant (P=0.001). Furthermore, the average of serum Cu concentration was 59.56±10.92 μg/dl before EXT, 60.48±10.05 μg/dl after EXT and 58.64±8.06 μg/dl five days after EXT that didn't vary significantly from each other.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The results showed that after EXT, the serum Zn concentration was higher than before EXT but the changes in serum Cu concentration was little and negligible. </span></p>

Serum Endocan, Neuron-Specific Enolase and Ischemia-Modified Albumin Levels in Newborns with Partial Blood Exchange Transfusion

2020 ◽  
Vol 23 ◽  
Author(s):  
Erbu Yarci ◽  
Cuneyt Tayman ◽  
Ufuk Cakir ◽  
Utku Serkant
Keyword(s):  
Exchange Transfusion ◽  
Neuronal Damage ◽  
Neuron Specific Enolase ◽  
Endothelial Damage ◽  
Control Group ◽  
Control Groups ◽  
Term Neonates ◽  
Blood Exchange ◽  
Blood Exchange Transfusion ◽  
And Control

Background:: Hyperviscosity of blood secondary to polycythemia results in increased resistance to blood flow and decrease in delivery of oxygen. Objective:: To evaluate whether serum endocan, NSE and IMA levels can be compared in terms of endothelial injury/ dysfunction and neuronal damage in term neonates with polycythemia who underwent PET. Methods:: 38 symptomatic polycythemic newborns having PET and 38 healthy newborns were included in the study. Blood samples for endocan, NSE and IMA were taken at only postnatal 24 hours of age in the control group and in polycytemia group just before PET, at 24 and 72 hours after PET. Results:: The polycythemia group had higher serum endocan(1073,4 ± 644,8 vs. 378,8 ± 95,9ng/ml; p<0.05), IMA(1,32 ± 0,34 vs.0,601 ± 0,095absorbance unit; p<0.05) and NSE(44,7 ± 4,3 vs. 26,91 ± 7,12μg/l; p<0.05) levels than control group before the PET procedure. At 24 hours after PET, IMA(0,656 ± 0,07 vs. 0,601 ± 0,095absorbance unit; p<0.05) and endocan(510,9 ± 228,6 vs. 378,8 ± 95,9ng/ml; p<0.05) levels were closer to the control group, being still statistically significant higher. NSE levels decreased to control group levels having no difference between the PET and control groups at 24 hours after PET (28,98 ± 6,5 vs. 26,91 ± 7,12μg/l; p>0.05). At 72 hours after PET the polycythemia and control groups did not differ statistically for IMA, endocan and NSE levels (p>0.05). Conclusion:: Serum endocan and IMA levels can be used as a biomarker for endothelial damage / dysfunction and tissue hypoxia in infants with symptomatic polycytemia.

Thrombotic Thrombocytopenic Purpura: Experience with Whole Blood Exchange Transfusion

1981 ◽  
Vol 7 (01) ◽  
pp. 25-32 ◽  
Author(s):  
Jerome Gottschall ◽  
Anthony Pisciotta ◽  
Joseph Darin ◽  
Clara Hussey ◽  
Richard Aster
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Whole Blood ◽  
Exchange Transfusion ◽  
Thrombocytopenic Purpura ◽  
Blood Exchange ◽  
Blood Exchange Transfusion

Ultrasound-Guided Fetal Blood Exchange Transfusion for Severe Erythroblastosis

1987 ◽  
Vol 27 (1) ◽  
pp. 70-71 ◽  
Author(s):  
Andrew C. C. Ngu† ◽  
H. P. Robinson† ◽  
L. Ch. Crespigny ◽  
M. Quinn† ◽  
L. Doyle†
Keyword(s):  
Exchange Transfusion ◽  
Fetal Blood ◽  
Ultrasound Guided ◽  
Blood Exchange ◽  
Blood Exchange Transfusion

Early blood exchange transfusion in malignant pertussis: A case report*

2011 ◽  
Vol 12 (2) ◽  
pp. e107-e109 ◽  
Author(s):  
Manuel Martinez ◽  
Isabelle Rochat ◽  
Regula Corbelli ◽  
Pierre Tissières ◽  
Peter C. Rimensberger ◽  
...  
Keyword(s):  
Case Report ◽  
Exchange Transfusion ◽  
Blood Exchange ◽  
Blood Exchange Transfusion

scholarly journals Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates – a 30 year prospective follow-up study

2013 ◽  
Author(s):  
Laura Hokkanen ◽  
Jyrki Launes ◽  
Katarina Michelsson
Keyword(s):  
Life Satisfaction ◽  
Exchange Transfusion ◽  
Family Type ◽  
Negative Consequences ◽  
Long Term Outcome ◽  
Growth Environment ◽  
Blood Exchange ◽  
Blood Exchange Transfusion

Background. Neonatal hyperbilirubinemia (HB) may cause severe neurological damage, but serious consequences are effectively controlled by phototherapy and blood exchange transfusion. HB is still a serious health problem in economically compromised parts of the world. The long term outcome has been regarded favorable based on epidemiological data, but has not been confirmed in prospective follow-up studies extending to adulthood.Methods. We studied the long term consequences of HB in a prospective birth cohort of 128 HB cases and 82 controls. The cases are part of a neonatal at-risk cohort (n=1196) that has been followed up to 30 years of age. HB cases were newborns ≥ 2500 g birth weight and ≥ 37 weeks of gestation who had bilirubin concentrations > 340µmol/l or required blood exchange transfusion. Subjects with HB were divided into subgroups based on the presence (affected HB) or absence (unaffected HB) of diagnosed neurobehavioral disorders in childhood, and compared with healthy controls. Subjects were seen at discharge, 5, 9 and 16 years of life and parent’s and teacher’s assessments were recorded. At 30 years they filled a questionnaire about academic and occupational achievement, life satisfaction, somatic and psychiatric symptoms including a ADHD self-rating score. Cognitive functioning was tested using ITPA, WISC, and reading and writing tests at 9 years of life. Results. Compared to controls, the odds for a child with HB having neurobehavioral symptoms at 9 years was elevated (OR=4.68). Fortyfive per cent of the HB group were affected by cognitive abnormalities in childhood and continued to experience problems in adulthood. This was apparent in academic achievement (p<0.0001) and the ability to complete secondary (p<0.0001) and tertiary (p<0.004) education. Also, the subgroup of affected HB reported persisting cognitive complaints e.g. problems with reading, writing and mathematics. Childhood symptoms of hyperactivity/impulsivity (p<0.0001) and inattention (p<0.02) were more common in HB groups, but in adulthood the symptoms were equal. The affected HB had lower scores in parameters reflecting life satisfaction, less controlled drinking, but not increased substance abuse. Discussion. Our results indicate that neonatal HB has negative consequences in adult age. A prospectively collected cohort with strict inclusion criteria enables to control most of the bias factors involved with retrospective data. The control and HB groups were remarkably similar at birth in terms of medical data, and the growth environment of the children, as well as the parents’ social groups, education, size of family, type of housing at birth and at 9 years of age. Our findings bear resemblance to disorders of the fronto-striatal network, and also symptoms of the ADHD spectrum were frequent in the HB group suggesting a link of HB to other neurodevelopmental disorders.

Blood exchange transfusion in viral hepatitis in a small infant: a case report

2020 ◽  
Vol 59 (6) ◽  
pp. 102907
Author(s):  
Thai Son Pham ◽  
Abdullah Reda ◽  
Thi Thu Ngan Nguyen ◽  
Sze Jia Ng ◽  
Vuong Thanh Huan ◽  
...  
Keyword(s):  
Case Report ◽  
Viral Hepatitis ◽  
Exchange Transfusion ◽  
Small Infant ◽  
Blood Exchange ◽  
Blood Exchange Transfusion

Exchange transfusion activates coagulation and alters the coagulation profile in newborn infants

2006 ◽  
Vol 96 (08) ◽  
pp. 142-148 ◽  
Author(s):  
Ulla Wartiovaara-Kautto ◽  
Sture Andersson ◽  
Markku Heikinheimo ◽  
Jari Petäjä ◽  
Satu Långström
Keyword(s):  
Exchange Transfusion ◽  
Standard Procedure ◽  
Newborn Infants ◽  
Lag Time ◽  
Coagulation System ◽  
Coagulation Profile ◽  
Adult Plasma ◽  
Thrombin Formation

SummaryExchange transfusion (ET) with adult blood is a standard procedure for neonates with severe hyperbilirubinemia. How ET affects newborn coagulation system remains, however, largely unknown. Thus, we prospectively evaluated the effect of ET on thrombin formation and coagulation profile in 18 newborns (22 ETs). Prothrombin fragment F1+2 and thrombin-antithrombin complexes increased considerably during ET while platelets were significantly reduced. Protein C increased less (p<0.001) and factorVIIIc more (p<0.001) than expected based on their levels in the infused blood. Further, in vitro thrombin generation initiated by5 pM tissue factor was analysed. Before the first ET, newborn endogenous thrombin potential (ETP) and thrombin peak remained at ≈60% of adult control plasma levels, but the lag time to thrombin burst in newborn plasma was ≈45% shorter than the lag time in adult plasma. At the end of the first ET, the thrombin burst still started ≈35% earlier in newborn than adult plasma, whereas ETP and thrombin peak were increased to >90% of adult levels. ETP and peak remained elevated at adult levels until the beginning of the second ET. APC-induced reductions in newborn ETP remained unaltered throughout the first ET. The reductions of ETP by APC were less pronounced in newborn than adult plasma (p<0.0001).We conclude that ET is associated with multiple procoagulant changes and increased in vivo thrombin formation. This ET-induced procoagulant challenge may be of clinical significance in sick newborns already prone to bleeding and thrombotic complications.

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