TA24 titanium alloy pipe with 638mm diameter and 19mm wall thickness is carried out continuous load flatten test, and the stress of internal and external pipe wall during flatten process is studied in this paper. The results show that the TA24 titanium alloy tube has good flattening performance, and the flattening process has experienced original stage, flattened oblate stage, flattened straight wall stage, flattened depressed stage, flattened concave contact stage. During the flattening process, the outer layer of the upper and lower wall of the tube is subjected to compressive stress, and the inner layer material is subjected to tensile stress. The tensile and compressive forces cause the vertical part of the upper and lower walls to be concave. The outer layer of the left and right circular arc parts is subjected to tensile stress and the inner layer is subjected to tensile stress. The compressive stress also causes the radius of the arc to decrease due to the combined force of the tensile and compressive forces, that is, the flattening occurs. With the decrease of and pressing distance under continuous loading condition, the metal on the left and right sides of the pipe gathers toward the middle depression, which aggravates the deformation of the upper and lower walls until the upper and lower walls contact, and the arc radius of the left and right walls decreases until the outer surface cracks. The pipe microstructure changes significantly into elongated deformation structure during the flattening process. The most severe part of the deformation is the left and right end arc of the pipe, followed by the upper and lower end depression.