scholarly journals Antidiabetic and Antilipidemic Effect of Aloe barbadensis Gel Extract in Alloxan Induced Diabetic Mice

2022 ◽  
Vol 36 (2) ◽  
Author(s):  
Syed Shahid Imran Bukhari ◽  
Nusrat Jahan ◽  
Muhammad Khalil Ahmed Khan ◽  
Mariam Zaheer ◽  
Sabir Javed
Keyword(s):  
Diabetic Mice ◽  
Aloe Barbadensis

scholarly journals Effect of ethanolic extract of Aloe vera (Aloe barbadensis) gel on blood glucose level of alloxan induced hyperglycaemic mice

2015 ◽  
Vol 30 (2) ◽  
pp. 25-31
Author(s):  
Shammin Haque ◽  
Ferdous Ara ◽  
Md Jalaluddin Iqbal ◽  
Halima Begum ◽  
Nazmun Nahar Alam
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Mice ◽  
Aloe Barbadensis ◽  
Aloe Vera Gel

The purpose of this study was to show the antidiabetic effect of ethanolic extract of Aloe vera gel in alloxan induced hyperglycaemic mice. Ethanolic extract of Aloe vera gel was orally administered for four weeks at a dose of 300mg/kg body weight. Weekly estimates of fasting blood glucose level in normal non-diabetic and alloxan induced hyperglycaemic mice were assessed. Ethanolic Aloe vera gel extract revealed no blood glucose lowering action upon non-diabetic mice. But, a significant reduction in blood glucose level (p<0.001) was seen in diabetic mice, when compared with diabetic control. Similar results were found when compared with a standard antidiabetic drug, gliclazide. To conclude, as administration of ethanolic extract of Aloe vera gel significantly reduces blood glucose level in hyperglycaemic mice, it can optimistically emerge as a new hope in the management of diabetes mellitus. DOI: http://dx.doi.org/10.3329/bjpp.v30i2.22680 Bangladesh J Physiol Pharmacol 2014; 30(2): 25-31

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

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