scholarly journals KIM-1 as a potential serological/urinological tumor-associated marker of renal cell carcinoma and chemotherapy nephrotoxicity

2019 ◽  
Vol 15 (3) ◽  
pp. 132-142 ◽  
Author(s):  
M. P. Solokhina ◽  
N. S. Sergeeva ◽  
N. V. Marshutina ◽  
I. I. Alentov ◽  
K. Yu. Kanukoev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Malignant Tumors ◽  
Kidney Injury ◽  
Renal Tubules ◽  
Highly Sensitive ◽  
Kidney Injury Molecule 1 ◽  
Serological Tumor

The last decades are characterized by an active search for highly sensitive and specific urinological and serological tumor-associated markers of renal cell carcinoma. This review analyses the results of studies of traditional serological tumor-associated markers and a potential new tumor-associated marker of renal cell carcinoma: kidney injury molecule-1, or KIM-1. The structure, sources and functions of KIM-1 in normal conditions and in damaged renal tubules, its potential role in carcinogenesis are described. The experience of using KIM-1 for specifying diagnosis of the most common histological types of renal cell carcinoma is analyzed. Data on KIM-1 expression in malignant tumors in other locations and non-oncological kidney disorders are presented. The role of KIM-1 in early diagnosis of nephrotoxic effect of antitumor drugs is described. The accumulated data is promising in regards to using KIM-1 in clinical oncology as a urinological and serological marker of renal cell carcinoma and chemotherapy nephrotoxicity.

Diagnostic role of kidney injury molecule-1 in renal cell carcinoma

2019 ◽  
Vol 51 (11) ◽  
pp. 1893-1902
Author(s):  
Kevin J. Zhang ◽  
George D. Wilson ◽  
Sam Kara ◽  
Audrey Majeske ◽  
Ping L. Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Kidney Injury ◽  
Diagnostic Role ◽  
Kidney Injury Molecule 1

scholarly journals Human Kidney Injury Molecule-1 Is a Tissue and Urinary Tumor Marker of Renal Cell Carcinoma

2005 ◽  
Vol 16 (4) ◽  
pp. 1126-1134 ◽  
Author(s):  
Won K. Han ◽  
Anwar Alinani ◽  
Chin-Lee Wu ◽  
Dror Michaelson ◽  
Massimo Loda ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Kidney Injury ◽  
Human Kidney ◽  
Kidney Injury Molecule 1

scholarly journals KIM-1 (kidney injury molecule 1) in the urine of renal cell carcinoma patients

2020 ◽  
Vol 16 (3) ◽  
pp. 21-28
Author(s):  
K. Yu. Kanukoev ◽  
N. S. Sergeeva ◽  
T. A. Karmakova ◽  
N. V. Marshutina ◽  
M. P. Solokhina ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Kidney Injury ◽  
Stage Iv ◽  
Mean Value ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Kidney Injury Molecule 1 ◽  
Disease Stages

Objective: to assess the potential clinical significance of KIM-1 (kidney injury molecule 1) as a urinological marker for kidney cancer.Materials and methods. An enzyme-linked immunosorbent assay was used to assess urinary KIM-1 (uKIM-1 — kidney injury molecule 1) levels in 67 patients with renal cell carcinoma (RCC) and 36 healthy volunteers (a control group).Results. Both in patients and in healthy individuals, uKIM-1 levels were age independent. A difference between mean uKIM-1 values in RCC patients (2.4 ± 0.2 ng/ml) and the control group (0.7 ± 0.1 ng/ml) was statistically significant (p <0.0001). In RCC patients the higher uKIM-1 level was observed at more advanced clinical disease stages: the values increasedfrom 2.0 ± 0.2 ng/ml at the stage I and 3.0 ± 0.5 ng/ml at the stage II—III to 4.4 ± 1.2 ng/ml at the stage IV. In the group of patients with stage IRCC, most representative by the number of cases (n = 44) the uKIM-1 levels correlated with the tumor size and were increased in patients with different histological subtypes of the tumor, including clear cell, papillary and chromophobe RCC. After nephrectomy, a monotonous decrease in uKIM-1 level was observed, and after 6 days its values approached the mean value in the control group. Two days after kidney resection, uKIM-1 increased and then decreased, remaining elevated after 6 days.Conclusion. This study demonstrates that uKIM-1 can be attributed to potentially significant urine tumor-associated markers of RCC.

scholarly journals Abstract 4604: Kidney injury molecule-1 regulates metastasis in renal cell carcinoma

2019 ◽  
Author(s):  
Jasper C. Lee ◽  
Marie A. Sarabusky ◽  
Audrey Champagne ◽  
Fabrice Lucien ◽  
Lakshman Gunaratnam
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Kidney Injury ◽  
Kidney Injury Molecule 1
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