scholarly journals EFFECTS OF VITAMIN D SUPPLEMENTATION ON THE ELECTROCARDIOGRAPH RECORDS OF PATIENTS WITH BETA THALASSEMIA MAJOR: AN OPEN-LABEL RANDOMIZED CLINICAL TRIAL

2020 ◽  
Vol 10 (1) ◽  
pp. 103-109
Author(s):  
Raz M. Hama Salih ◽  
◽  
Marwan S.M. Al-Nimer ◽  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Vitamin D Supplementation ◽  
Beta Thalassemia ◽  
Open Label ◽  
Beta Thalassemia Major

scholarly journals Effects of vitamin D supplementation on red cell indices and cytokines in patients with thalassemia: An open-label randomized clinical trial

2019 ◽  
pp. 170-179
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Vitamin D Supplementation ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Open Label ◽  
Hematological Indices ◽  
Red Cell Indices

Background and aim Deficiency of vitamin D is known as a health problem all over the world and a recognized clinical complication of beta thalassemia patients. Vitamin D acts as a hormone at the nuclear receptor rendering it a beneficial medication for a number of diseases. It is believed that vitamin D is important in the modulation of the inflammation system by regulating the formation of inflammatory cytokines and immune cells. This study aimed to investigate the effect of vitamin D supplementation on the red cell indices and cytokines levels in patients with beta thalassemia major, in an open label randomized clinical trial. Patients and Methods: this study performed an open-label randomized clinical trial in patients with beta thalassemia major. Forty-six patients completed the eight weeks clinical trial and were allocated to administer oral vitamin D3 supplement of 100,000 IU every two weeks as an add-on treatment. During the study, hematological indices, serum iron, ferritin, vitamin D, calcium and inflammatory markers (interleukin-6, interleukin-2 and interleukin-10) were evaluated before (at baseline) and after vitamin D supplementation for 8 weeks. Results: Vitamin D3 supplements significantly decreases interleukin-6 levels and elevates the serum levels of anti-inflammatory cytokines IL-2 and IL-10, it also significantly reduced serum ferritin level, but it did not alter the hematological indices. Conclusion: Our results suggest that administration of vitamin D has a potential anti-inflammatory role in beta thalassemia patients and reduces serum ferritin levels, which may reduce the burdens of iron overload in thalassemia patients.

The Effect of a Holistic Care Program on the Reduction of Iron Overload in Patients with Beta-Thalassemia Major: A Randomized Clinical Trial

2018 ◽  
Vol 20 (4) ◽  
Author(s):  
Mahdieh Arian ◽  
Robabeh Memarian ◽  
Mohammad Bagher Oghazian ◽  
Farveh Vakilian ◽  
Zahra Badiee
Keyword(s):  
Clinical Trial ◽  
Iron Overload ◽  
Randomized Clinical Trial ◽  
Care Program ◽  
Thalassemia Major ◽  
Holistic Care ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Reduction Of Iron

scholarly journals The Effects of Nutrition, Exercise, and a Praying Program on Reducing Iron Overload in Patients With Beta-Thalassemia Major: A Randomized Clinical Trial

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Zahra Molazem ◽  
Roghaye Noormohammadi ◽  
Roya Dokouhaki ◽  
Maryam Zakerinia ◽  
Zahra Bagheri
Keyword(s):  
Clinical Trial ◽  
Iron Overload ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major

Effect of nine months of vitamin D supplementation on muscle performance in Graves' disease: a double-blinded, randomized clinical trial

2019 ◽  
Author(s):  
Diana Grove-Laugesen ◽  
Sofie Malmstrom ◽  
Eva Ebbehoj ◽  
Anne Lene Riis ◽  
Torquil Watt ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Vitamin D Supplementation ◽  
Muscle Performance ◽  
Graves Disease ◽  
Double Blinded

scholarly journals Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial

2018 ◽  
Vol 74 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Li Chen ◽  
Yanbin Dong ◽  
Jigar Bhagatwala ◽  
Anas Raed ◽  
Ying Huang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dna Methylation ◽  
Vitamin D ◽  
African Americans ◽  
Randomized Clinical Trial ◽  
Vitamin D3 ◽  
Vitamin D Supplementation ◽  
P Value ◽  
Epigenetic Aging ◽  
Vitamin D3 Supplementation

Abstract Background We have previously shown that vitamin D supplementation increases telomerase activity, suggesting an anti-aging effect. In this study, we aim to test the hypothesis that vitamin D supplementation would slow down epigenetic aging, a new marker of biological aging. Methods A randomized clinical trial was previously conducted among 70 overweight/obese African Americans with serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L, who were randomly assigned into four groups of 600 IU/d, 2,000 IU/d, 4,000 IU/d of vitamin D3 supplements or placebo followed by 16-week interventions. Whole genome-wide DNA methylation analysis was conducted in 51 participants. DNA methylation ages were calculated according to the Horvath and the Hannum methods. Methylation-based age acceleration index (∆Age) is defined as the difference between DNA methylation age and chronological age in years. Mixed-effects models were used to evaluate the treatment effects. Results Fifty-one participants (aged 26.1 ± 9.3 years, 16% are male) were included in the study. After the adjustment of multi-covariates, vitamin D3 supplementation of 4,000 IU/d was associated with 1.85 years decrease in Horvath epigenetic aging compared with placebo (p value = .046), and 2,000 IU/d was associated with 1.90 years decrease in Hannum epigenetic aging (p value = .044). Serum 25(OH)D concentrations were significantly associated with decreased Horvath ∆Age only (p values = .002), regardless of treatments. Conclusions Our results suggest that vitamin D supplementation may slow down Horvath epigenetic aging. But the effect on Hannum epigenetic aging is not conclusive. Large-scale and longer duration clinical trials are needed to replicate the findings.

scholarly journals Safety Aspects of a Randomized Clinical Trial of Maternal and Infant Vitamin D Supplementation by Feeding Type Through 7 Months Postpartum

2020 ◽  
Vol 15 (12) ◽  
pp. 765-775
Author(s):  
Carol L. Wagner ◽  
Thomas C. Hulsey ◽  
Myla Ebeling ◽  
Judy R. Shary ◽  
Golaleh Asghari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Vitamin D Supplementation ◽  
Safety Aspects ◽  
Feeding Type
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