scholarly journals ANALYSIS OF SPONTANEOUS REPORTS OF ADVERSE REACTIONS IN PATIENTS WITH CORONARY ARTERY DISEASE IN THE REPUBLIC OF CRIMEA

2018 ◽  
Vol 7 (4) ◽  
pp. 26-32
Author(s):  
O. V. Matveev ◽  
A. E. Krasheninnikov ◽  
N. M. Kiseleva ◽  
E. A. Egorova ◽  
A. G. Dormidor
Keyword(s):  
Coronary Artery Disease ◽  
Drug Reaction ◽  
Coronary Artery ◽  
Adverse Drug Reactions ◽  
Ace Inhibitors ◽  
Adverse Reactions ◽  
Drug Reactions ◽  
Spontaneous Reports ◽  
The Republic ◽  
Artery Disease

Aim. To analyze spontaneous reports of adverse drug reactions in patients with coronary artery disease in the Republic of Crimea for the fve-year period from January 2011 to August 2016.Methods. 332 reports of adverse drug reactions in patients with coronary artery disease collected in the “ARCADe” database were analyzed. Out of them, 231 reports on essential drugs affecting the cardiovascular system were selected. The age of patients who reported adverse drug reactions ranged from 37 to 90 years.Results. The rate of adverse drug reaction reports increased with patients’ aging, reaching its maximum (31.6% of all drug reaction reports) by 70–80 years. The incidence of adverse reactions was higher among women (63.6%), which is generally consistent with other studies. However, men receiving nitrates had a 3.4-fold increase in the rate of adverse drug reactions compared to women. The highest rate of adverse drug reactions was associated with ACE inhibitors (29.0%), and in particular Enalapril, which is probably explained by a higher rate of their prescriptions, compared to other drugs.Conclusion. Most of the reported adverse drug reactions were expected. The frequent development of allergic reactions (16% out of all adverse reactions in this study) in patients with coronary artery disease were associated with ACE inhibitors, betablockers and antithrombotic agents.

scholarly journals Major Aspects of Detection and Monitoring of Adverse Reactions Associated with Cephalosporin Antibiotic Treatment

2021 ◽  
Vol 9 (1) ◽  
pp. 34-42
Author(s):  
E. Yu. Demchenkova ◽  
G. I. Gorodetskaya ◽  
I. A. Mazerkina ◽  
M. V. Zhuravleva ◽  
A. S. Kazakov ◽  
...  
Keyword(s):  
Adverse Events ◽  
Adverse Drug Reactions ◽  
Patient Information ◽  
Adverse Reactions ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Patient Information Leaflets ◽  
Information Leaflets ◽  
Spontaneous Reports ◽  
Cephalosporin Antibiotics

Widespread use of cephalosporin antibiotics in clinical practice calls for greater attention to the risk of adverse drug reactions. Information on serious or unexpected adverse events reported during post-marketing experience is submitted to national and international pharmacovigilance databases. Analysis of these reports helps to identify new adverse drug reactions.The aim of the study was to analyse the safety profile of cephalosporin antibiotics based on spontaneous reports in the international VigiBase database.Materials and methods: the analysis of the adverse reaction profile of cephalosporin antibiotics was based on MedDRA system organ classes and included spontaneous reports submitted to VigiBase from the moment of its creation until August 2020.Results: the authors identified the most clinically significant adverse reactions for different cephalosporin generations. They compared and analysed information on adverse events in VigiBase and in patient information leaflets of medicinal products authorised in the Russian Federation. It was demonstrated that some serious events described in VigiBase spontaneous reports for V-generation cephalosporins are not included in the “Side effects” section of the patient information leaflets. According to VigiBase, the use of ceftaroline was associated with the development of generalised exfoliative dermatitis, Stevens–Johnson syndrome, tubulointerstitial nephritis, while the use of ceftolozane was associated with acute kidney injury, renal insufficiency, sepsis, pneumonia, and respiratory insufficiency.Conclusion: reporting of unexpected and serious adverse drug reactions to cephalosporin antibiotics is an important task of healthcare practitioners. Availability of information on class-specific and generation-specific serious adverse reactions will help predict and prevent their development.

High Prevalence of Risk Factors in Coronary Artery Disease in EUROPA Gives HOPE for ACE Inhibitors after PEACE

Cardiology ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Sune A. Pedersen ◽  
Søren Galatius ◽  
Michael Hecht Olsen ◽  
Bente Kühn Madsen ◽  
Jan Kyst Madsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Ace Inhibitors ◽  
High Prevalence ◽  
Artery Disease

scholarly journals CLOPIDROGEL INDUCED LEUKOCYTOCLASTIC VASCULITIS

2017 ◽  
Vol 10 (7) ◽  
pp. 9 ◽  
Author(s):  
Navin Patil ◽  
Balaji O ◽  
Karthik Rao ◽  
Talha A ◽  
Chaitan Chaitan
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Leukocytoclastic Vasculitis ◽  
Age Groups ◽  
Hospital Setting ◽  
Antiplatelet Drug ◽  
Drug Reactions ◽  
Drug Induced ◽  
Hypersensitivity Vasculitis ◽  
Artery Disease

Cutaneous adverse drug reactions are very common in a hospital setting while treating patients. Drug-induced vasculitis is a very common form of vasculitis affecting all age groups, and many drugs have been implicated in causing vasculitis. Clopidogrel is an antiplatelet drug used in the management as well as prevention of coronary artery disease. It is known to cause various side effects ranging from bleeding, gastrointestinal disturbances, to skin rashes. Leukocytoclastic vasculitis is a form of hypersensitivity vasculitis and is very rarely seen with clopidogrel. Hence, we report a case of clopidogrel-induced leukocytoclastic vasculitis in an old male patient after coronary stenting. 

ACE-inhibitors in coronary artery disease?

1993 ◽  
pp. 43-64
Author(s):  
Martin Vogt ◽  
W. Motz ◽  
B. E. Strauer
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Ace Inhibitors ◽  
Artery Disease

Abstract 3526: Medication Non-adherence Is Associated With A Broad Range Of Adverse Outcomes In Patients With Coronary Artery Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
P. Michael Ho ◽  
David J Magid ◽  
Susan M Shetterly ◽  
Kari L Olson ◽  
Thomas M Maddox ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Ace Inhibitors ◽  
Adverse Outcomes ◽  
Care Organization ◽  
Increased Risk ◽  
Β Blockers ◽  
Artery Disease ◽  
Revascularization Procedures

Background: Little is known about the effect of non-adherence among coronary artery disease (CAD) patients on a broad spectrum of outcomes including cardiovascular mortality, cardiovascular hospitalizations or revascularization procedures. Methods: This was a retrospective cohort study of 15,767 patients with CAD in a managed care organization. Medication adherence was calculated as proportion of days covered (PDC) for filled prescriptions of β-blockers, ACE-inhibitors, and statin medications. Multivariable Cox regression assessed the association between medication non-adherence as a time-varying covariate and mortality (all-cause and cardiovascular), adjusting for demographics and clinical characteristics. Median follow-up was 4.1 years. Results: Across the three classes of medications, non-adherent patients were more likely to be younger and have a diagnosis of COPD or depression. In unadjusted analysis, non-adherence to each individual class of medication was associated with higher all-cause and cardiovascular mortality. In multivariable analysis, non-adherence remained significantly associated with increased all-cause mortality risk for β-blockers (HR 1.50; 95% CI 1.33–1.71), ACE-inhibitors (HR 1.74; 95% CI 1.52–1.98), and statins (HR 1.85; 95% CI 1.63–2.09). In addition, non-adherence remained significantly associated with higher risk of cardiovascular mortality for β-blockers (HR 1.53; 95% CI 1.16 –2.01), ACE-inhibitors (HR 1.66; 95% CI 1.26 –2.20), and statins (HR 1.62; 95% CI 1.124 –2.13). The findings of increased risk associated with non-adherence were consistent for cardiovascular hospitalization and revascularization procedures. Conclusions: Non-adherence to cardioprotective medications is associated with a broad range of adverse outcomes. These findings support the importance of non-adherence in clinical practice and suggest that medication non-adherence should be a target for future interventions.

scholarly journals Retrospective analysis of adverse drug reaction reporting forms associated with penicillin family antibiotics (pcne-drp 9.0) based on drug-related approach

2020 ◽  
Vol 8 (1) ◽  
pp. 57-64 ◽  
Author(s):  
A. V. Matveev ◽  
A. E. Krasheninnikov ◽  
E. A. Egorova ◽  
E. I. Koniaeva
Keyword(s):  
Adverse Drug Reactions ◽  
Adverse Reactions ◽  
Adverse Drug Reaction Reporting ◽  
Drug Hypersensitivity ◽  
Clinical Manifestations ◽  
Drug Related Problems ◽  
Drug Reactions ◽  
Spontaneous Reports ◽  
Amoxicillin Clavulanate

A widespread use of β-lactam antibiotics such as penicillins in practical medicine, and its authorized use in special categories of patients (e.g. children, pregnant and lactating women, the elderly) requires a critical investigation of their safety as well as the obligatory risk assessment before conducting antibacterial pharmacotherapy.The aim of the work was the conduction of a retrospective study of adverse reactions cases, the identification and analysis of drug-related problems (DRP) associated with the use of penicillin family antibiotics.Materials and methods. The objects of the study were adverse drug reactions (ADR) associated with the use of penicillin family antibiotics in inpatient and outpatient facilities, as well as the cases of self-treatment, which were recorded in the official ADR reports and then inputted in the regional (Republic of Crimea) database of spontaneous reports called ARCADe (Adverse Reactions in Crimea, Autonomic Database). The covered period is 2009–2018. The analysis of DRP was carried out using the 9.0 version of the qualification system DRP PCNE (Pharmaceutical Care Network Europe Foundation).Results. The data analysis of ADR reporting forms has revealed that Amoxicillin clavulanate and Amoxicillin were the most frequent cause of ADR. A high incidence of penicillins ADR in pediatric patients (from 0 to 18 years) – 142 cases – has been found. The clinical manifestations of reactions included drug hypersensitivity reactions (309 cases), dyspeptic disorders (28 cases) and disorders of the central nervous system (5 cases). The incidence of serious ADR was 113 cases (33% of the total number of ADR in the study), which indicates a rather high risk of developing severe ADR for penicillins, resulted in a significant decrease in the quality of patients’ lives.Conclusion. The detection of DRP using the PCNE V9.0 approach is a useful and promising tool important to improve the quality of pharmacotherapy and their adherence to treatment. The highest DRP values which were observed for Amoxicillin clavulanate and Amoxicillin, may indicate a high frequency of irrational use of these drugs.List of abbreviations: DRP – drug related problems; ADR – adverse drug reactions; INN – international non-patented name

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