Cranial bones mark hormonal disturbances in patients with gonadal dysgenesis

2021 ◽  
Vol 50 (2) ◽  
pp. 100-102
Author(s):  
E. V. Uvarova ◽  
A. I. Volobujev ◽  
T. V. Rudneva ◽  
S. V. Rudnev

The data on roentgenologic peculiarities o f cranial bones including sella turcica in patients with gonadal dysgenesis are drawn in the paper. Besides that, the authors analyze the changes in size and configuration o f sella turcica under hormonal replacement therapy.

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Biwen Cheng

Abstract Background Gynecologic anomalies, including uterine agenesis and ovarian dysgenesis, are some of the several differential diagnoses in adolescent females with primary amenorrhea and delayed puberty. Primary ovarian insufficiency is reported in the clinical practice of reproductive endocrinology can be determined by conducting sex hormone tests to evaluate the hypothalamic-pituitary-ovarian axis. However, confirmation of Mullerian agenesis by image modalities can be extremely challenging. Once the diagnosis is established, breakthrough bleeding usually occurs 2 to 3 years after hormonal replacement therapy. Case presentation We report a case of a seventeen year old Taiwanese female, 46 XX karyotype, with ovarian dysgenesis and an initial tentative diagnosis of uterine agenesis who experienced a breakthrough bleeding after a month of hormonal replacement therapy. Conclusions The breakthrough bleeding after a month of estrogen therapy in primary ovarian insufficiency is uncommon, and the diagnosis of the absent uterus can have an extensive psychological impact on patients and their families.


Author(s):  
Lourdes G. Baeza-Perez ◽  
Claudia Calzada-Mendoza ◽  
Maria Elena Hernandez-Campos ◽  
Pedro Lopez-Sanchez ◽  
Liliana Anguiano-Robledo

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