scholarly journals Treatment of atrial flutter (Vorhofsflimmerri). Drury Ilieskn and Wedd (Brit. Med. J., 24 / IX 1921)

2021 ◽  
Vol 18 (2) ◽  
pp. 107-107
Author(s):  
V. G.
Keyword(s):  
Atrial Flutter ◽  
Gelatin Capsules ◽  
Quinidine Sulfate ◽  
J 24

Drury Ilieskn and Wedd (Brit. Med. J., 24 / IX 1921) used quinidine sulfate in 13 cases of this suffering, and after the patients were free of foxglove and strophanthus, they were first given 0.2 quinidine peros in order to find out , do they tolerate this remedy, and then the systematic use of the latter has already begun, again peros, in gelatin capsules.

Intraneuronal accumulations of lysosomes in the cerebellum of rats and dogs after dosing with MDL-832

1990 ◽  
Vol 48 (3) ◽  
pp. 830-831
Author(s):  
S.D. Barnard ◽  
S.D. Warner
Keyword(s):  
Brown Pigment ◽  
Beagle Dogs ◽  
Sprague Dawley ◽  
Gelatin Capsules ◽  
Pigment Granules ◽  
Sprague Dawley Rats ◽  
Hematoxylin And Eosin ◽  
Dose Levels

1, 2, 9, 10-tetramethoxyaporphine phosphate (MDL-832) was once considered a potential human antitussive. MDL-832 was administered orally in the diets of Sprague-Dawley rats at dose levels of 0, 5, 10, 20, 40, 80 and 160 mg/kg/day for 3 and 6 months and in gelatin capsules to Beagle dogs at 0, 5, 10, 15, 30 and 60 mg/kg/day for 3, 6 and 12 months. Histopathologic examinations of hematoxylin and eosin-stained cerebellar sections revealed intracytoplasmic brown pigment accumulations in large fusiform neurons (presumably the motor type) of the pons. The pigment granules were found to be PAS-positive, non-acid fast, iron-free, Sudan B-positive and fuchsinophilic. Intraneuronal pigment accumulations were seen in rats after 3 months of treatment at 80 mg but not at 40 mg and after 6 months at 20 mg but not at 10 mg. For dogs the effect was observed after 3 months at 60 mg but not at 30 mg and after 12 months at 10 mg but not at 5 mg.

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