Comparison of Curative Effect of Cryosupernatant and Fresh Frozen Plasma at Complex Treatment of Disseminated Intravascular Coagulation Syndrome in Patients with Severe Concomitant Injury

2011 ◽  
Vol 18 (4) ◽  
pp. 49-53
Author(s):  
Evgeniy Aleksandrovich Tseymakh ◽  
A A Men'shikov ◽  
A V Bondarenko ◽  
S Yu Kuznetsov ◽  
I N Gontarev ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Fresh Frozen Plasma ◽  
Complex Treatment ◽  
Curative Effect ◽  
Intravascular Coagulation ◽  
Complex Therapy ◽  
Fresh Frozen ◽  
Thrombotic Complications ◽  
Fibrinolysis Activity ◽  
Frozen Plasma

Results of comparative study of cryoplasmic therapy applied at complex treatment of 168 patients with disseminated intravascular coagulation syndrome were presented. In 56 patients complex therapy included cryosupernatant plasma (CSNP) and 112 patients received fresh frozen plasma (FFP). Study of coagulation and fibrinolysis system showed that restoration of fibrinolysis activity, physiologic anticoagulants and normalization of plasma fibrinogen levels occurred sooner when CSNP was used. Application of CSNP promoted the relaxation of disease severity, prevention of thrombotic complications and decrease of lethality (by 14.2%) to a greater extent as compared to FFP use.

Purpura Fulminans in a Chinese Boy With Congenital Protein C Deficiency

PEDIATRICS ◽  
1986 ◽  
Vol 77 (5) ◽  
pp. 670-676
Author(s):  
Patrick Yuen ◽  
Alfred Cheung ◽  
Hsiang Ju Lin ◽  
Faith Ho ◽  
Jun Mimuro ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Protein C ◽  
Purpura Fulminans ◽  
Fresh Frozen Plasma ◽  
Protein C Deficiency ◽  
Intravascular Coagulation ◽  
The Family ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Congenital Protein C Deficiency

Severe and recurrent purpura fulminans developed in a Chinese boy at one day of age. Results of coagulation studies performed on the patient during attacks were compatible with the diagnosis of disseminated intravascular coagulation. Subsequent investigations have revealed that the patient is homozygous and that his parents are heterozygous for protein C deficiency. Cryoprecipitate and fresh frozen plasma induced a remission, and administration of warfarin has been successful in preventing recurrence of attacks for as long as 8 months without infusion of any plasma components. None of the family members who are heterozygous for protein C deficiency have had thrombotic episodes.

The bleeding patient

2020 ◽  
pp. 403-428
Author(s):  
Anne Craig ◽  
Anthea Hatfield
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Disseminated Intravascular Coagulation ◽  
Oxygen Supply ◽  
Fresh Frozen Plasma ◽  
Blood Transfusions ◽  
Massive Blood Transfusion ◽  
Intravascular Coagulation ◽  
Fresh Frozen ◽  
Frozen Plasma

Part one of this chapter tells you about the physiology of blood and oxygen supply, about anaemia and tissue hypoxia, and the physiology of coagulation. Drugs that interfere with clotting are discussed. Bleeding, coagulation, and platelet disorders are covered as well as disseminated intravascular coagulation. Part two is concerned with bleeding in the recovery room: how to cope with rapid blood loss, managing ongoing blood loss, and how to use clotting profiles to guide treatment. There is also a section covering blood transfusion, blood groups and typing. Massive blood transfusion is clearly described, there are guidelines about when to use fresh frozen plasma, when to use platelets, and when to use cryoprecipitate. The final section of the chapter is about problems with blood transfusions.

scholarly journals Pathogenesis, diagnosis, prevention and treatment of disseminated intravascular coagulation syndrome in COVID-19 infection

2020 ◽  
Vol 92 (11) ◽  
pp. 51-56
Author(s):  
P. A. Vorobyev ◽  
A. P. Momot ◽  
L. S. Krasnova ◽  
A. P. Vorobiev ◽  
A. K. Talipov
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Fresh Frozen Plasma ◽  
Clotting Factors ◽  
Intravascular Coagulation ◽  
Prevention And Treatment ◽  
Fresh Frozen ◽  
Direct Anticoagulants ◽  
Frozen Plasma

Aim. Clinical characteristics of disseminated intravascular coagulation (DIC) in COVID-19 infection and assessment of the effectiveness of complex therapy for this syndrome at the stages of prevention and treatment of various complications. Materials and methods. The study of publications was carried out through search engines on the Internet using keywords. To diagnose the infection, the COVID-19 program was used on the MeDiCase platform, which is publicly available on www.medicase.pro, which suggests a diagnosis with a sensitivity of 89.47%. The study included 85 patients with acute COVID-19 with mild to moderate disease, aged 11 to 81 years. The presence of the pathogen was confirmed immunologically in 12% of patients; in other cases, the diagnosis was based on the results of an automated survey in the MeDiCase system. All patients, according to the MGNOT recommendations, were prescribed one of the oral direct anticoagulants - Eliquis at a dose of 5 mg 2 times a day, Ksarelto at a dose of 10 mg 2 times a day or Pradax at a dose of 110 mg 2 times a day for at least 2 weeks. All other drugs with antiviral, immunomodulatory effects, antibiotics were canceled. Results. The presence of DIC is substantiated by the morphological picture of changes in organs and tissues, clinical (hematoma-petechial type of bleeding in combination with thromboembolic syndrome and the presence of thrombovasculitis) and laboratory changes: an increase in the level of soluble fibrin-monomer complexes, D-dimer, hyperfibrinogenaemia, less often - thrombocytopenia, violation of fibrinolytic activity. The phenomenon of consumption of clotting factors and profuse bleeding are rare. Direct anticoagulants, fresh frozen plasma transfusions and plasmapheresis are used in the treatment of disseminated intravascular coagulation. The paper presents its own positive results of early prescription at the outpatient stage of direct oral anticoagulants in prophylactic doses (no case of disease progression), individual cases of the use of fresh frozen plasma and plasapheresis. Conclusion. DIC syndrome with the development of thrombovasculitis is the most important pathogenetic mechanism for the development of microthrombotic and hemorrhagic disorders in organs during infection with COVID-19, leading to dysfunction of the lungs, brain and other nerve tissues, kidneys, thromboembolic complications, etc. Many symptoms of the disease may be associated with a violation of the nervous regulation of the functions of organs and systems. Prevention of thrombovasculitis is effective already at the stage of the first manifestation of the disease with the outpatient use of direct anticoagulants (oral, low molecular weight heparins). In case of more severe manifestations (complications) of the disease, additional use of freshly frozen plasma and plasmapheresis is effective.

560: TREATMENT OF DISSEMINATED INTRAVASCULAR COAGULATION WITH CONTINUOUS FRESH FROZEN PLASMA

2018 ◽  
Vol 46 (1) ◽  
pp. 265-265
Author(s):  
Brandi McCall ◽  
Olakunle Idowu ◽  
Raymond Moreno ◽  
Kristen Price ◽  
Joseph Nates
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Fresh Frozen Plasma ◽  
Intravascular Coagulation ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Chronic Disseminated Intravascular Coagulation: A Case Report

2009 ◽  
Vol 1 (1) ◽  
pp. 33
Author(s):  
Md Abul Kalam Azad ◽  
M Abdul Kader ◽  
M Abdul Jalil Chowdhury ◽  
Tofayel Ahmed
Keyword(s):  
Case Report ◽  
Disseminated Intravascular Coagulation ◽  
Fresh Frozen Plasma ◽  
Clotting Factors ◽  
Fresh Blood ◽  
Intravascular Coagulation ◽  
Coagulation Mechanism ◽  
Significant Clinical Improvement ◽  
Fresh Frozen ◽  
Frozen Plasma

<p>In health there is a balance between the coagulation and anti-coagulation systems, but in disseminated intravascular coagulation (DIC) the coagulation mechanism is activated inappropriately and in a diffuse way. This may lead to thrombosis, but more often haemorrhage occurs when the clotting factors are exhausted. DIC may present as acute, subacute, and rarely chronic form. Here we present a case of chronic DIC following pelvic inflammatory disease (PID) as a consequence of repeated menstruation regulation (MR). We treated her with fresh frozen plasma, fresh blood, doxycycline with significant clinical improvement.</p><p>DOI: 10.3329/bsmmuj.v1i1.3696</p> <p><em>BSMMU J </em>2008; 1(1): 33-34</p>

Early Blood Transfusion and Resolution of Disseminated Intravascular Coagulation Associated with Massive Subgaleal Hemorrhage

2016 ◽  
Vol 35 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Houchang Modanlou ◽  
Shandee Hutson ◽  
Allan Thurman Merritt
Keyword(s):  
Blood Transfusion ◽  
Respiratory Distress ◽  
Disseminated Intravascular Coagulation ◽  
Health Care Professionals ◽  
Male Infant ◽  
Fresh Frozen Plasma ◽  
Resonance Imaging ◽  
Intravascular Coagulation ◽  
Fresh Frozen ◽  
Frozen Plasma

AbstractA male infant delivered to a primipara woman following vacuum applications. He was vigorous at birth, with small caput and scalp bruising. His head was enlarging; he became pale with respiratory distress. Subgaleal hemorrhage (SGH) was suspected. His hematocrit was noted to be 26.2 percent prior to transfusion of O, Rh-negative blood (40 mL/kg). Moderate disseminated intravascular coagulation (DIC) was noted at 12 hours of age. Posttransfusion of fresh frozen plasma (FFP), his condition became stable, and DIC gradually resolved. Head magnetic resonance imaging did not show intracranial hemorrhage. Although one episode of seizures was noted, electroencephalogram was normal.With the application of obstetric vacuum, we recommend that the neonatal health care professionals frequently evaluate the infant’s condition. In light of developing fluctuant subgaleal fluid associated with pallor, anemia, metabolic acidosis, and respiratory distress, immediate blood transfusion is warranted. In the presence of DIC, transfusion of FFP is beneficial.

Disseminated Intravascular Coagulation In Patients With Fatty Liver Of Pregnancy. Onset Of Dic Prior To Labor

1981 ◽  
Author(s):  
H Liebman ◽  
R Sandler ◽  
M J Patch ◽  
W G McGehee
Keyword(s):  
Fatty Liver ◽  
Disseminated Intravascular Coagulation ◽  
Fresh Frozen Plasma ◽  
Screening Tests ◽  
Bleeding Complications ◽  
Intravascular Coagulation ◽  
Active Labor ◽  
At Iii ◽  
Fresh Frozen ◽  
Frozen Plasma

Fatty liver of pregnancy (FLP) is a rare syndrome with a high maternal mortality. Bleeding complications are frequent and are associated with disseminated intravascular coagulation (DIC). We have previously demonstrated that DIC in this syndrome can be persistent, lasting 2 to 6 days, and is associated with severe depressions of functional and antigenic antithrombin III (AT III). The severe depression of AT III in this syndrome is believed to secondary to decreased hepatic synthesis and increased consumption from DIC. We have hypothesized that DIC is initiated by active labor, persists because of the low levels of AT III and may be controlled by transfusion of fresh frozen plasma or AT III concentrate. Recently we saw a patient with FLP proven by biopsy who presented with jaundice, nausea, and emesis. The patient was not in active labor. In preparation for surgical delivery, coagulation studies were done which revealed DIC (abnormal screening tests, fibrinogen of 70mg/dl, fibrin split products of 320-640 ng/dl, depressed factors V ᶓ VIII and a positive protamine sulfate test). The patient was given 1500 cc of fresh frozen plasma and viable twins were surgically delivered on the second hospital day. Following delivery DIC subsided, but infusions of plasma were continued until the fourth hospital day.Subsequently we measured AT III using a fluorometric synthetic substrate (Protopath-see table above). From our observations on this patient we conclude (1) active labor is not necessary for the initiation of DIC in FLP (2) DIC in FLP can be associated with non-detectable functional AT III (3) transfusions of fresh frozen plasma can significantly increase functional AT III and may control DIC.

A Retrospective Propensity Score-Matched Early Thromboembolic Event Analysis of Prothrombin Complex Concentrate vs Fresh Frozen Plasma for Warfarin Reversal Prior to Emergency Neurosurgical Procedures

Neurosurgery ◽  
2017 ◽  
Vol 82 (6) ◽  
pp. 877-886 ◽  
Author(s):  
Prateek Agarwal ◽  
Kalil G Abdullah ◽  
Ashwin G Ramayya ◽  
Nikhil R Nayak ◽  
Timothy H Lucas
Keyword(s):  
Propensity Score ◽  
Intracranial Hemorrhage ◽  
Fresh Frozen Plasma ◽  
Neurosurgical Procedures ◽  
Thrombotic Complication ◽  
Propensity Score Matching Analysis ◽  
Therapeutic Anticoagulation ◽  
Fresh Frozen ◽  
Thrombotic Complications ◽  
Frozen Plasma

AbstractBACKGROUNDReversal of therapeutic anticoagulation prior to emergency neurosurgical procedures is required in the setting of intracranial hemorrhage. Multifactor prothrombin complex concentrate (PCC) promises rapid efficacy but may increase the probability of thrombotic complications compared to fresh frozen plasma (FFP).OBJECTIVETo compare the rate of thrombotic complications in patients treated with PCC or FFP to reverse therapeutic anticoagulation prior to emergency neurosurgical procedures in the setting of intracranial hemorrhage at a level I trauma center.METHODSSixty-three consecutive patients on warfarin therapy presenting with intracranial hemorrhage who received anticoagulation reversal prior to emergency neurosurgical procedures were retrospectively identified between 2007 and 2016. They were divided into 2 cohorts based on reversal agent, either PCC (n = 28) or FFP (n = 35). The thrombotic complications rates within 72 h of reversal were compared using the χ2 test. A multivariate propensity score matching analysis was used to limit the threat to interval validity from selection bias arising from differences in demographics, laboratory values, history, and clinical status.RESULTSThrombotic complications were uncommon in this neurosurgical population, occurring in 1.59% (1/63) of treated patients. There was no significant difference in the thrombotic complication rate between groups, 3.57% (1/28; PCC group) vs 0% (0/35; FFP group). Propensity score matching analysis validated this finding after controlling for any selection bias.CONCLUSIONIn this limited sample, thrombotic complication rates were similar between use of PCC and FFP for anticoagulation reversal in the management of intracranial hemorrhage prior to emergency neurosurgical procedures.

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