scholarly journals COMBINED USE OF HYALURONIC ACID WITH NANO-BIOACTIVE GLASS ENHANCED BIOCEMENT BASED SILICATE STIMULATED BONE REGENERATIVE CAPACITY IN TIBIAL BONE DEFECTS OF RABBITS: IN-VIVO STUDY

2021 ◽  
Vol 9 (5) ◽  
pp. 630-638
Author(s):  
Fatema Aziz Al-Sayed ◽  
◽  
Radwa Hamed Hegazy ◽  
Zeinab Amin Salem ◽  
Hanan Hassan El-Beheiry ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Bone Area ◽  
Regenerative Capacity ◽  
Tibial Bone ◽  
Group 3 ◽  
Area Percentage ◽  
Group 1

An ideal biomaterial for bone regeneration is a longstanding quest nowadays. This study aimed to evaluate the osteogenic potentiality of nano-bioactive glass enhanced biocement based silicate with or without hyaluronic acid seeded in rabbits’ tibial bone defects. For this, 24 male rabbits with two 5 mm defects (1 defect per tibia) were divided into three equal groups. Among the predefined three groups, for the rabbits of group 1(control) bone defects were left untreated while for the members of group 2 defects received nano-bioactive glass enhanced biocement based silicate cement, and group 3 defects received nano-bioactive glass cement mixed with hyaluronic acid. Animals of each group were divided equally for euthanization after 3 and 6 weeks. Bone specimens were processed and examined histologically with histomorphometrically analysis of new bone area percentage. The bone defects in group 3 showed significantly improved osseous healing histologically as compared to the group 1&2. The morphometric analysis also revealed a significant increase in the new bone area percentage in group 3 as compared to the group 1 and 2 (P < 0.05). The results of the present study can be concluded that bone defects could be treated with nano-bioactive glass and hyaluronic acid cement. Although, nano-bioactive glass alone was capable of bone regeneration the combination of both had significant regenerative capacity.

scholarly journals Local delivery of a novel PTHrPviamesoporous bioactive glass scaffolds to improve bone regeneration in a rat posterolateral spinal fusion model

RSC Advances ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 12484-12493 ◽  
Author(s):  
Bo Liang ◽  
Jinghuan Huang ◽  
Jianguang Xu ◽  
Xiaolin Li ◽  
Jingfeng Li
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Spinal Fusion ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Local Delivery ◽  
Long Bones ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

With the development of tissue engineering, bone defects, such as fractured long bones or cavitary lesions, may be efficiently repaired and reconstructed using bone substitutes.

scholarly journals STUDY OF THE PLATELET-RICH PLASMA CLINICAL EFFICACY IN THE TREATMENT OF KNEE OSTEOARTHRITIS

2016 ◽  
Vol 7 (3) ◽  
pp. 54-60
Author(s):  
G D Lazishvili ◽  
К A Egiazaryan ◽  
A A Akhpashev ◽  
M A Danilov ◽  
M A Strakhov ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Clinical Efficacy ◽  
Detection Rate ◽  
Platelet Rich Plasma ◽  
Analog Scale ◽  
Womac Index ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The study of platelet-rich plasma efficacy in the treatment of patients with knee osteoarthritis (OA) was performed. 188 patients were included and divided into three groups. Group 1 - 82 patients with OA, where hyaluronic acid was used for treatment, Group 2 - 36 patients, and Platelet Rich Plasma (PRP) and hyaluronic acid were used, Group 3 - 70 patients, only PRP was used. It`s been found that the use of PRP for treatment is characterized by a pronounced clinical efficacy compared with use of hyaluronic acid, which manifests in reduced detection rate of edema, hyperthermia and hyperemia. The use of PRP leads to pain reduction in the knee joint and increase the functionality of patients, that confirmed by more pronounced declining of visual analog scale indicators, Leken index and the WOMAC index values increase. The presented results of study are consistent with authors who believe that the lack of side effects and complications when using PRP indicates the safety of its use in clinical practice.

Comparison of bone regeneration rate in flat and long bone defects: Calvarial and tibial bone

2013 ◽  
Vol 10 (6) ◽  
pp. 336-340 ◽  
Author(s):  
Jiwon Lim ◽  
Jongman Lee ◽  
Hui-Suk Yun ◽  
Hong-In Shin ◽  
Eui Kyun Park
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
Long Bone ◽  
Regeneration Rate ◽  
Tibial Bone

Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study)

2008 ◽  
Vol 24 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Nayer S. AboElsaad ◽  
Mena Soory ◽  
Laila M. A. Gadalla ◽  
Laila I. Ragab ◽  
Stephen Dunne ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects

scholarly journals Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Wanwisa Suwannaloet ◽  
Wiroon Laupattarakasem ◽  
Peerapol Sukon ◽  
Siriwan Ong-Chai ◽  
Pisamai Laupattarakasem
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Lesion ◽  
Type Ii Collagen ◽  
Treated Group ◽  
Left Knee ◽  
Full Thickness ◽  
Grading Scale ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA.

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

2018 ◽  
Vol 107 (1) ◽  
pp. 50-64 ◽  
Author(s):  
Ahmad Oryan ◽  
Mohamadreza Baghaban Eslaminejad ◽  
Amir Kamali ◽  
Samaneh Hosseini ◽  
Forough Azam Sayahpour ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Radial Bone

Gene delivery nanocarriers of bioactive glass with unique potential to load BMP2 plasmid DNA and to internalize into mesenchymal stem cells for osteogenesis and bone regeneration

Nanoscale ◽  
2016 ◽  
Vol 8 (15) ◽  
pp. 8300-8311 ◽  
Author(s):  
Tae-Hyun Kim ◽  
Rajendra K. Singh ◽  
Min Sil Kang ◽  
Joong-Hyun Kim ◽  
Hae-Won Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gene Delivery ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Plasmid Dna ◽  
Bone Defects ◽  
Unique Potential ◽  
Stimulation Of

Nanocarriers of bioactive glass loading BMP2 plasmid DNA are effective for the osteogenic stimulation of mesenchymal stem cells and the healing of bone defects.

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