Diagnostic efficacy cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer

BackgroundLung cancer is still the main cause of cancer deaths. The high lung cancer mortality rate is caused by a diagnosis factor or therapy selection. The cell block cytology technique using fine needle aspiration (FNA) samples can provide immunocytochemical material that plays an important role in the differential diagnosis of lung cancer subtypes and in determining immunotherapy administration. This study aimed to determine the sensitivity and specificity of transthoracic FNA (TTFNA) cell block cytology in comparison with bronchial washing smears and TTFNA smears in diagnosing lung cancer. MethodsThis was a cross-sectional diagnostic study involving 26 subjects. All subjects had undergone bronchial washing and CT scan-guided fine needle aspiration followed by cell block preparation. Both direct FNA smears and cell blocks are useful in the diagnostic work-up of patients. Comparative statistical analysis of TTFNA cell block versus bronchial washing smear and TTFNA smear cytology was carried out using the McNemar test. ResultsLung cancer was found in 15 patients (57.7%) using the TTFNA cell block technique. The sensitivity and specificity of the TTFNA cell block technique were 85.7% and 75%, respectively. There was no difference in the positivity value between TTFNA cell block technique of bronchial wash smear technique, and TTFNA smear on lung cancer diagnosis (p>0.05). ConclusionsTransthoracic fine-needle aspiration in combination with the cell block technique has good sensitivity and specificity. The TTFNA can be used for immunocytochemical examinations in lung cancer diagnosis and therapy. This approach is valuable for providing individualized treatment and prognostic evaluations.

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The value of cell block based on fine needle aspiration for lung cancer diagnosis

Journal of Thoracic Disease ◽

10.21037/jtd.2017.07.91 ◽

2017 ◽

Vol 9 (8) ◽

pp. 2375-2382 ◽

Cited By ~ 10

Author(s):

Zhengwei Dong ◽

Hui Li ◽

Jun Zhou ◽

Wei Zhang ◽

Chunyan Wu

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Cell Block ◽

Fine Needle ◽

Lung Cancer Diagnosis ◽

Block Based

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The utility of transbronchial (Wang) fine needle aspiration in lung cancer diagnosis

Cytopathology ◽

10.1046/j.1365-2303.2001.00287.x ◽

2001 ◽

Vol 12 (1) ◽

pp. 7-14 ◽

Cited By ~ 6

Author(s):

M. T. Siddiqui ◽

M. H. Saboorian ◽

S. T. Gokaslan ◽

G. Lindberg ◽

R. Ashfaq

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Fine Needle ◽

Lung Cancer Diagnosis

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Lung cancer: 1 year experience at tertiary care centre with reference to cytodiagnostic approach

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20170096 ◽

2017 ◽

Vol 4 (1) ◽

pp. 133

Author(s):

Mansi Mehta ◽

Nisha Gupta ◽

Jaydeep Odhwani ◽

Nandini Desai ◽

P. M. Santwani

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Brush Cytology ◽

Fine Needle ◽

Bronchial Washing ◽

Diagnosis Of Lung Cancer

Background: Lung cancer is the most common cancer incidence wise as well as leading cause of cancer related death in worldwide as well as in India. Cytological diagnosis plays an important role in patients having lung cancer. This study was conducted to evaluate sensitivity of various cytological methods in diagnosis of lung cancer, to study typing of lung cancer, age and gender wise distribution of lung cancer and its association with smoking.Methods: This study includes patients having clinical and radiological diagnosis of lung cancer. Total 150 cases of entire January 2015 to December 2015 are included. Methods obtaining samples includes, abrasive cytology by bronchoscope guided: bronchoalveolar lavage (BAL); brush cytology and bronchial washing, CT/USG guided transthoracic fine needle aspiration, trans- bronchial needle aspiration. Samples have been processed as per standard protocols and cytomorphology of samples are studied, along with these patient age, gender, and smoking habit have been recorded.Results: Sensitivity of various method: abrasive cytology by bronchoscope guided bronchoalveolar lavage (BAL); brush cytology and bronchial washing, trance bronchial needle aspiration, CT/USG guided transthoracic fine needle aspiration is 70%, 66%, 90% respectively. Adenocarcinoma is most common carcinoma followed by squamous carcinoma, having incident of 41%, 31.39% respectively. In male patient peak age is 5th decade, and in female peak age is 6th decade. Male:female ratio is 5.1:1. Adenocarcinoma is most common carcinoma is 10 times more common in non-smokers as compare to squamous cell carcinoma .But association of squamous cell carcinoma with smoking is 97%.Conclusions: CT/USG guided transthoracic fine needle aspiration method has highest sensitivity. In male patients peak age of presentation of lung carcinoma is 5th decade, and in female patient’s peak age is 6th decade. Lung carcinoma found to be more common in males than in females. Adenocarcinoma is most common carcinoma. It is 10 times more common in non-smokers as compare to squamous cell carcinoma. Association of squamous cell carcinoma with smoking is 97%.

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