scholarly journals Role of ST2 biomarker for the evaluation of myocardial remodeling in patients with ischemic heart failure with preserved ejection fraction

Kardiologiia ◽  
2018 ◽  
Vol 17 (S10) ◽  
pp. 33-43
Author(s):  
K. V. Kop’eva ◽  
◽  
A. T. Teplyakov ◽  
E. V. Grakova ◽  
M. V. Soldatenko ◽  
...  

2021 ◽  
Author(s):  
Hidenobu Hashimoto ◽  
Rine Nakanishi ◽  
Sunao Mizumura ◽  
Yukiko Hashimoto ◽  
Yuriko Okamura ◽  
...  

Abstract Purpose This study aimed to determine whether coronary artery calcium score (CACS) can be a prognostic indicator for the development of major adverse cardiac events (MACEs) and compare the value of CACS with that of the 123I-betamethyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) defect score (BDS) in patients with non-ischemic heart failure with preserved ejection fraction (NIHFpEF). Methods Among 643 consecutive patients hospitalized due to acute heart failure, 108 (74 ± 13y) were identified to have NIHFpEF on non-contrast regular chest computed tomography and 123I-BMIPP single-photon emission computed tomography (SPECT). We evaluated whether CACS and BDS were associated with MACEs using multivariate Cox models. Results Thirty-two MACEs developed at a mean follow-up period of 2.4 years. Higher CACS (hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.10–4.67) and higher BDS (HR 22.14, 95% CI 7.95–61.60) were significantly associated with the development of MACEs. Patients showing higher CACS and BDS carried a significantly higher risk for developing MACE (HR 23.65, 95% CI 10.33–54.13, p < 0.001). Conclusion CACS, as well as BDS, could serve as potential prognostic indicators in patients with NIHFpEF.



2010 ◽  
Vol 6 (2) ◽  
pp. 33 ◽  
Author(s):  
Christopher R deFilippi ◽  
G Michael Felker ◽  
◽  

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.



Author(s):  
Monil Majmundar ◽  
Rajkumar Doshi ◽  
Harshvardhan Zala ◽  
Palak Shah ◽  
Devina Adalja ◽  
...  


2021 ◽  
Author(s):  
James P. MacNamara ◽  
Vivek Koshti ◽  
I‐Jou Cheng ◽  
Katrin A. Dias ◽  
Christopher M. Hearon ◽  
...  


2008 ◽  
Vol 5 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Michael Bauer ◽  
Bruno K. Podesser


2021 ◽  
pp. postgradmedj-2021-139933
Author(s):  
Akash Batta ◽  
Ganesh Kasinadhuni ◽  
Manphool Singhal ◽  
Pankaj Malhotra ◽  
Rajesh Vijayvergiya


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