Contribution of antioxidant systems to regeneration of tracheal epithelium after burn of upper respiratory tract

Study was performed using a rat model of thermal burn of upper respiratory tract (URT). The URT burn in rats was induced by intratracheal instillation of 70 °C water vapor using a micro-vapor generator. In a week after the intervention about 50 % of the ciliated epithelium was destructed. In 2 weeks after the intervention the inflammatory response enhanced and tissue edema increased. In 4 weeks after the intervention partial irregular restoration of tracheal epithelium cells was observed. Both IL-1 and IL-4 expression did not change significantly during restoration of tracheal epithelium, but IL-8 and IL-10 expression increased and was high even 1 month after the burn. Simultaneously, dramatic increase in expression of peroxyredoxine 6, which is the main antioxidant protein in trachea, was observed during regeneration of trachea epithelium. Iimmunohistochemical investigations showed that the increase in peroxyredoxine 6 in trachea during the regeneration of trachea epithelium after the burn could be related to increased peroxyredoxine expression in goblet cells. Therefore, activation of peroxyredoxine 6 synthesis by goblet cells appears to be the key step in activation of epithelium defense systems after thermal burn.

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Differences in the Mode of Secretion of Goblet Cells in the Upper Respiratory Tract of Various Vertebrate Classes

Acta Veterinaria Brno ◽

10.2754/avb199261010011 ◽

1992 ◽

Vol 61 (1) ◽

pp. 11-15 ◽

Cited By ~ 1

Author(s):

I. Těšík

Keyword(s):

Respiratory Tract ◽

Goblet Cells ◽

Upper Respiratory Tract ◽

Upper Respiratory

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Distribution of Antileukoprotease in Upper Respiratory Mucosa

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948209100308 ◽

1982 ◽

Vol 91 (3) ◽

pp. 268-271 ◽

Cited By ~ 30

Author(s):

Ulla Fryksmark ◽

Kjell Ohlsson ◽

Åsa Polling ◽

Hans Tegner

Keyword(s):

Molecular Weight ◽

Respiratory Tract ◽

Enzyme Inhibitors ◽

Goblet Cells ◽

Low Molecular Weight ◽

Upper Respiratory Tract ◽

Human Respiratory Tract ◽

Submucosal Glands ◽

Upper Respiratory ◽

Acid Stable

Human respiratory tract secretions contain enzyme inhibitors derived from plasma and a low molecular weight, acid-stable protease inhibitor, antileukoprotease. The distribution of antileukoprotease in normal upper respiratory tract mucosa has been studied using an immunohistologic technique. The inhibitor was localized to the serous parts of the submucosal glands of the maxillary sinus and the trachea but was not demonstrable in mucous glands and goblet cells. It is concluded that the antileukoprotease found in respiratory tract secretions is produced locally in the submucosal serous glands.

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ACTIVITY OF FREE RADICAL PROCESSES IN MIXED SALIVA OF PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS

Clinical Practice ◽

10.17816/clinpract65014 ◽

2021 ◽

Author(s):

Tatiana S. Gomel State Medical University, Gomel ◽

Irina A. Novikova

Keyword(s):

Respiratory Tract ◽

Respiratory Tract Infections ◽

Upper Respiratory Tract Infections ◽

Antioxidant Systems ◽

Control Group ◽

Upper Respiratory Tract ◽

Diene Conjugates ◽

Upper Respiratory ◽

Tract Infections ◽

Mixed Saliva

The study conducted a comprehensive assessment of the state of the pro-/antioxidant mixed saliva system of 64 healthy individuals and 85 patients with recurrent upper respiratory tract infections RIURT. At the same time, the determination of the parameters of pro-/antioxidant systems was carried out using two methods (photometric: the content of lipid peroxidation products and the level of ceruloplasmin and luminal-dependent chemiluminescence (LDHL) was determined, which allows assessing the complex interaction of two systems - prooxidants and antioxidants). Studies have demonstrated that most patients with RIURT during remission on individual components of prooxidants (diene conjugates, ketodienes, Schiff bases;), as well as saliva antioxidant (ADS: ceruloplasmin) levels were elevated compared to controls. At the same time, the LDHL saliva parameters did not go beyond the reference interval, although they were changed relative to the median of the control group. This allows us to consider the observed fluctuations as a balance in the system of pro- and antioxidants.

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Bronchiolitis

Pediatrics in Review ◽

10.1542/pir.7.7.219 ◽

1986 ◽

Vol 7 (7) ◽

pp. 219-222

Author(s):

Peter F. Wright

Keyword(s):

Respiratory Tract ◽

Lymphocytic Infiltration ◽

Goblet Cells ◽

Small Airways ◽

Upper Respiratory Tract ◽

Whole Process ◽

Ciliary Function ◽

Upper Respiratory ◽

Diagnosis Therapy ◽

Submucosal Edema

Bronchiolitis is an acute respiratory disease of early childhood characterized clinically by upper respiratory tract signs of rhinitis and congestion and by lower respiratory tract signs of tachypnea, retractions, wheezing, and rales. The presence of wheezing differentiates bronchiolitis from many of the other entities to be considered in the child with respiratory distress. Fever and other systemic signs are not prominent components of bronchiolitis. Radiographically, there is evidence of hyperexpansion of the chest, thickening of the bronchial walls, and areas of atelectasis or interstitial pneumonia. Physiologically, there is evidence of hypoxia and hypercarbia with disequilibrium of perfuson-ventilation. Pathologically, there is evidence of damage to the mucosal epithelium with loss of ciliary function. There is an increased production of mucus, with a proliferation of goblet cells. Submucosal edema and lymphocytic infiltration are common. These changes are seen throughout the respiratory tract but are particularly prominent in the cells and submucosal lining of the bronchioles, with resultant obstruction of the small airways (Fig 1). The pathologic events are obviously central to the whole process of the illness. An understanding of the mechanisms by which the pathologic changes in bronchiolitis evolve, and their implications for diagnosis, therapy, prognosis, and, ultimately, prevention, will be the focus of this review.

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