The role of single nucleotide polymorphisms in GIPR gene in the changes of secretion in hormones and adipokines in patients with obesity with type 2 diabetes

2018 ◽  
Vol 64 (2) ◽  
pp. 208-216 ◽  
Author(s):  
D.A. Skuratovskaia ◽  
M.A. Vulf ◽  
E.V. Kirienkova ◽  
N.I. Mironyuk ◽  
P.A. Zatolokin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Receptor Gene ◽  
Obese Patients ◽  
Nucleotide Polymorphisms ◽  
Normal Expression ◽  
Before And After ◽  
Regulation Of Carbohydrate Metabolism ◽  
Plasma Leptin

The relationship between the rs2302382, rs8111428 and Glu354Gln (rs1800437) polymorphisms in GIPR (glucosedependent insulinotropic polypeptide receptor) gene and plasma levels of mediators involved in the regulation of carbohydrate metabolism in obese patients with type 2 diabetes (before and after a test breakfast) was investigated. The contribution of polymorphic variants of rs2302382, rs8111428 in GIPR gene in the predisposition to type 2 diabetes in individuals belonging to the Slavic population of Russia was found. Polymorphisms rs2302382 and rs8111428 in the GIPR gene were characterized by the nonequilibrium cohesion. The decrease in the level of expression of the GIPR gene in adipose tissue of the small intestine mesentery in the carriers of the CC genotype rs2302382 and AA rs8111428 was associated with the increase in the plasma leptin level, whereas during normal expression, the plasma content of insulin, and GIP (in persons with the genotype of the polymorphism rs2302382 and AG polymorphism rs8111428), resistin and ghrelin (in individuals with the genotype of the polymorphism rs2302382) increased. We propose the stimulating effect of GIP on the secretion of resistin, leptin and ghrelin, with an increase in insulin production in obese patients with type 2 diabetes.

scholarly journals Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Priscila Sala ◽  
Raquel Susana Matos de Miranda Torrinhas ◽  
Danielle Cristina Fonseca ◽  
Graziela Rosa Ravacci ◽  
Dan Linetzky Waitzberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Methylation Profile ◽  
Obese Patients ◽  
Tissue Specific ◽  
Before And After

scholarly journals SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sara Mankoč Ramuš ◽  
Tina Kumše ◽  
Mojca Globočnik Petrovič ◽  
Daniel Petrovič ◽  
Ines Cilenšek
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Strong Association ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Regulatory Molecule ◽  
Codominant Model ◽  
Osteoprotegerin Gene

Recent studies indicate that osteoprotegerin (OPG) acts as an important regulatory molecule in the vasculature. Also, a strong association was observed between circulation OPG and microvascular complication. By considering the possible role of OPG in diabetic retinopathy (DR) we examined two of the most studied polymorphisms of the OPG genes rs2073618 (located in exon I) and rs3134069 (located in the promoter region) and their relation to DR in Slovenian patients with type 2 diabetes. Logistic regression analysis demonstrated that the carriers of the CC genotype had a 2.2 higher risk for DR than those with either the CG genotype or the GG genotype (codominant model for rs2073618). Furthermore, the combined effect of single nucleotide polymorphisms (SNPs) rs2073618 and rs3134069 on the DR was stronger than that of each SNP alone. The odds ratio (OR) for individuals with CC genotype (rs2073618) and AA genotype (rs3134069) compared with carriers of CG/GG (rs2073618) + AA (rs3134069) was 2.54 (95% CI = 1.26–5.13, ). To conclude, these results indicate that SNPs in the OPG gene may be implicated in the pathogenesis of DR.

Role of the Gly40Ser Mutation in the Glucagon Receptor Gene in Brazilian Patients With Type 2 Diabetes Mellitus

Pancreas ◽  
2002 ◽  
Vol 24 (4) ◽  
pp. 386-390 ◽  
Author(s):  
Debora Shiota ◽  
Teresa Kasamatsu ◽  
Sergio A. Dib ◽  
Antonio R. Chacra ◽  
Regina S. Moisés
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Receptor Gene ◽  
Glucagon Receptor ◽  
Glucagon Receptor Gene

Role of Neuronal Guidance Cues in the Pathophysiology of Obesity: A Peripheral and Central Overview

2021 ◽  
Vol 27 ◽  
Author(s):  
Daniela Sayuri Inoue ◽  
Mohammad Fauzan Bin Maideen ◽  
Alberto Jiménez-Maldonado ◽  
Fábio Santos Lira
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Diseases ◽  
Low Grade ◽  
Obese Patients ◽  
Guidance Cues ◽  
Integrative View ◽  
New Treatments ◽  
Neuronal Guidance

: Obesity is associated with an exacerbated synthesis and secretion of several molecules, which culminates in chronic low-grade inflammation and insulin resistance. Such conditions affect molecular and physiological responses of several organs and, if not resolved, predispose to the obese patients to suffer other diseases such as Type 2 diabetes, atherosclerosis, cancer, neural injuries, and cognitive impairments. A microenvironment with an excess of pro-inflammatory cytokines released by different cells, including immune and adipose cells lead to suffer metabolic and non-metabolic diseases during obesity. In this context, the role of neuronal guidance cues named netrin, semaphorin and ephrin is novel. Specifically, the available literature indicates that besides to their classic role as molecules that guide to the axon with its target site, the neuronal guidance cues exhibit immunomodulatory functions from adipose tissue to the neural environment. In the current narrative review, we discuss the participation of the neuronal guidance cues on the physiology and pathophysiology of obesity. We also discuss the feedback loop of the obesity on the netrin, semaphorin and ephrin functions that impair the structure and function of the brain. The integrative view of the neuronal guidance cues can be relevant to design new treatments focused to attenuate metabolic and immune disorders that suffering obese patients, and lead to them to acquire worse diseases such as Type 2 diabetes, atherosclerosis, cancer, and neural injuries.

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