scholarly journals Study on drug profile used in common pregnancy influenced issues and its complications

2021 ◽  
Vol 10 (10) ◽  
pp. 1196
Author(s):  
Semmalar G. V. ◽  
Kaviya Anisha S. J. ◽  
Terry Sheetal B. ◽  
Saravanakumar R. T. ◽  
Latha K.
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Gestational Hypertension ◽  
Dual Therapy ◽  
Premature Delivery

Background: Pregnancy influenced issues are common among pregnant women treated by medications that causes complication in mother and fetus. The study aims to identify patients with pregnancy influenced issues like gestational diabetes mellitus, gestational hypertension, gastroesophageal reflux disease and anaemia. To assess the drug used pattern along with antibiotic therapy and to observe the above disease related complications.Methods: A hospital based prospective observational study was conducted at department of obstetrics and gynecology in Rajah Muthiah Medical College and Hospital. Totally 100 patients enrolled and data was collected using data collection form.Results: Out of 100 patients, high prevalence occurred in 26-30 years of age. Primarily gestational hypertension (39%), treated with Tab. Labetatol and complications were premature delivery, low birth weight. Anaemia (25%) cases treated with Tab. Ferrous sulphate, Iron sucrose and Folic Acid, Preterm delivery as complication. Gestational diabetes mellitus (18%) treated with Metformin and Human Insulin and complications were preterm delivery, maternal obesity, increased child weight. GERD (8%) treated with Pantoprazole, Ondansetron, Bifilac and complications were weight loss, dehydration, low birth weight. In pre-operative cases, 79% received antibiotics as monotherapy and 21% as dual therapy. In post-operative cases, 41% received antibiotics as monotherapy and 59% as dual therapy. Metronidazole (95%) given in both post and pre- operative conditions.Conclusions: The present study provides valuable insight about the overall drugs used in pregnancy related diseases and complications arise. We hope our data will make necessary recommendations to all health care professionals and pregnant women to ensure all pregnancy related safety measures were taken.

scholarly journals Maternal and fetal outcomes of obese pregnant women: a prospective cohort study

2017 ◽  
Vol 6 (2) ◽  
pp. 725
Author(s):  
Jenniferbritto John ◽  
Mary Mahendran
Keyword(s):  
Diabetes Mellitus ◽  
Caesarean Section ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Maternal Obesity ◽  
Gestational Hypertension ◽  
Induction Of Labour ◽  
Control Group ◽  
Fetal Outcomes

Background: Obesity in Indian women had increased from 10.6% to 14.8% in India. Mothers who are overweight or obese during pregnancy and childbirth cause significant antenatal, intrapartum, postpartum and also neonatal complications. The present study aimed to explore various maternal and fetal outcomes influenced by maternal obesity. The objective was to find the effect of obesity on maternal and perinatal outcome among obese pregnant women compared to those of normal weight.Methods: The study was conducted in antenatal women attending antenatal outpatient department of CSI rainy multispecialty hospital located in North Chennai of South India. Consecutive sampling method was followed to include 50 cases and 50 controls. Analysis was done with IBM SPSS v.21.0. Chi square test was applied to find difference between proportions. For comparison of means independent t-test and ANOVA was applied. Pearson's correlation was done to find association between maternal BMI and birth weight.Results: Sixteen (32%) cases developed gestational diabetes mellitus during their antenatal period and 19 (38%) developed gestational hypertension. 10% underwent in emergency caesarean section and in 28% cases elective caesarean section was done. The proportion of cases who developed ante partum complications including gestational diabetes mellitus, gestational hypertension and preeclampsia were higher than in control groups (p value = 0.03,0.00,0.004 respectively). The need for induction of labour and caesarean section was found to be higher in cases than in controls (p = 0.014,0.03 respectively). Increased NICU admissions for stabilization of the newborn among cases was higher than control group (p = 0.012).Conclusions: It was clearly evident from the present study that maternal obesity had adverse maternal and fetal outcomes. Maternal obesity was strongly associated with antenatal complications like gestational diabetes mellitus, gestational hypertension, preeclampsia and increase in need for induction of labour and operative interference.

scholarly journals DETERMINANTS OF GESTATIONAL DIABETES MELLITUS

2021 ◽  
Vol 17 (37) ◽  
pp. 48-56
Author(s):  
Yuli Puspita DEVI ◽  
Rumaisah ABDILLAH ◽  
Muthmainnah MUTHMAINNAH
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Secondary Data ◽  
Perinatal Complications ◽  
Family History Of Diabetes ◽  
History Of

Background: Gestational Diabetes Mellitus (GDM) is a glucose tolerance disorder that first appears during pregnancy. GDM can cause a variety of obstetric and perinatal complications for pregnant women and their fetuses. The prevalence of GDM in the city of Surabaya in 2015 amounted to 2.29%, increasing to 3.88% in 2018. Aim: The purpose of this study was to analyze the determinants (family history of diabetes mellitus, BMI, history of birth weight, parity, and the age of the pregnant woman) that influence the GDM. Methods: This research is an analytical study with an observational approach. The research design was carried out using a case-control study. In this study, the number of samples was 36 people, 6 cases, and 30 people as controls, and were taken randomly. The data source obtained from secondary data (medical records of pregnant women) at Mulyorejo Health Center Surabaya. The analysis used in this study was a simple logistic regression test. Results and Discussion: The result showed an effect of a family history of diabetes mellitus (p = 0.035) on the incidence of GDM. Parity was a potential variable (p = 0.077) on the incidence of GDM. Meanwhile, BMI, history of birth weight, and mother's age did not affect the incidence of GDM. Conclusion: Pregnant women with a family history of diabetes who are not balanced with maintaining a good lifestyle can experience complications of developing GDM.

scholarly journals One-day outpatient health management prevents hazardous events during fetal childbirth of gestational diabetes mellitus

2021 ◽  
Author(s):  
Dan Zheng ◽  
Yan Luo ◽  
Mou-meng Zheng ◽  
jing Liu ◽  
Yang Lu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Premature Birth ◽  
Health Management ◽  
Management Program ◽  
Low Birth Weight Infants ◽  
The Mean

Abstract Background: To analyze the effects of one-day outpatient health management on premature birth, macrosomia, and low-birth-weight infants in patients with gestational diabetes mellitus (GDM).Methods: Medical records of patients with gestational diabetes mellitus in our hospital during 2019 were retrospectively collected, including basic information, family history, and pregnancy complications. The outcomes, including preterm birth, macrosomia , and low-birth-weight infants, of patients receiving one-day outpatient health management or not were observed. Logistic regression analysis was used to detect the potential relationship between one-day outpatient health management and outcomes.Results: A total of 1393 patients with gestational diabetes mellitus presented to Guiyang Maternal and Child Health Hospital in 2019, including 104 premature births, 91 low-birth-weight infants, and 71 macrosomia infants. The mean age of the selected subjects was 33.06 ± 4.83 and the mean body mass index was 22.78 ± 3.18 kg/m2. A total of 535 (38.41%) patients with gestational diabetes mellitus volunteered to participate in the one-day outpatient health management program. This health management [odds ratio = 0.474 (95% confidence interval 0.272–0.826)] was a protective factor for macrosomia; however, it was not associated with premature birth and low-birth-weight.Conclusions: The degree of acceptance of patients with gestational diabetes mellitus to a one-day outpatient health management program is still low. This health management program reduced the risk of macrosomia in patients with gestational diabetes mellitus by 52.6%. In the future, regular follow-up should be introduced in clinical practice to further improve the effects of one-day programs.

scholarly journals Serum miR-29a/b expression in gestational diabetes mellitus and its influence on prognosis evaluation

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095476
Author(s):  
Li Deng ◽  
Yan Huang ◽  
Ling Li ◽  
Hongfei Chen ◽  
Junyou Su
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Premature Delivery ◽  
Healthy Group ◽  
Serum Microrna

Objective To evaluate serum microRNA (miR)-29a/b expression in gestational diabetes mellitus (GDM) and its influence on neonatal prognosis. Methods This was a retrospective study including 68 pregnant women with GDM (GDM group) and 55 healthy pregnant women of similar age range and gestation period (healthy group). Results The area under the curve was 0.829 for the diagnosis of GDM using serum miR-29a expression, 0.857 for diagnosis using serum miR-29b expression, and 0.944 for combined diagnosis (using both miR-29a and miR-29b). The fasting insulin (FINS) level of the GDM group was significantly lower than that of the healthy group; levels of fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), and glycated hemoglobin (HbA1c) were significantly higher in the GDM group than in the healthy group. Both miR-29a and miR-29b were positively correlated with FINS levels and negatively correlated with FPG, 2hPG, and HbA1c levels. Serum miR-29a/b expression in pregnant women with GDM was not correlated with neonatal weight, premature delivery, or asphyxia but was correlated with pathologic jaundice. Conclusions Serum miR-29a/b expression was downregulated in pregnant women with GDM and correlated with neonatal pathologic jaundice, showing good individual (miR-29a or miR-29b) diagnostic value and excellent combined (miR-29a and miR-29b) diagnostic value.

scholarly journals Effect of Probiotic Supplementation on Newborn Birth Weight for Mother with Gestational Diabetes Mellitus or Overweight/Obesity: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3477
Author(s):  
Chun-Chi Wang ◽  
Yu-Tang Tung ◽  
Hua-Ching Chang ◽  
Chang-Hsien Lin ◽  
Yang-Ching Chen
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Mean Difference ◽  
High Birth Weight ◽  
Probiotic Supplementation ◽  
Probiotic Intervention

High birth weight indicates the future risk of obesity and increased fat mass in childhood. Maternal gestational diabetes mellitus (GDM) or overweight are powerful predictors of high birth weight. Studies on probiotic supplementation during pregnancy have reported its benefits in modulating gut microbiota composition and improving glucose and lipid metabolism in pregnant women. Therefore, probiotic intervention during pregnancy was proposed to interrupt the transmission of obesity from mothers to newborns. Thus, we performed a meta-analysis to investigate the effect of probiotic intervention in pregnant women with GDM or overweight on newborn birth weight. We searched PubMed, EMBASE, Cochrane Library, and Web of Science databases up to 18 December 2019. Randomized controlled trials (RCTs) comparing pregnant women with GDM or overweight who received probiotic intervention during pregnancy with those receiving placebo were eligible for the analysis. Newborn birth weights were pooled to calculate the mean difference with a 95% confidence interval (CI). Two reviewers assessed the trial quality and extracted data independently. Seven RCTs involving 1093 participants were included in the analysis. Compared with the placebo, probiotics had little effect on newborn birth weight of pregnant women with GDM or overweight (mean difference = −10.27, 95% CI = −90.17 to 69.63, p = 0.801). The subgroup analysis revealed that probiotic intake by women with GDM decreased newborn birth weight, whereas probiotic intake by obese pregnant women increased newborn birth weight. Thus, no evidence indicates that probiotic intake by pregnant women with GDM or overweight can control newborn birth weight.

Endocrine Disease

2019 ◽  
Author(s):  
Eric Morell ◽  
Feyce Peralta
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Premature Birth ◽  
Pregnancy Loss ◽  
Overt Hypothyroidism ◽  
Key Words Diabetes ◽  
Endocrine Disease

Endocrine disease has become increasingly prevalent in parturients, primarily due to the increase in prevalence of diabetes mellitus. Both preexisting diabetes mellitus and gestational diabetes mellitus are associated with significant maternal and fetal complications. The Hyperglycemia and Adverse Pregnancy Outcome study demonstrated that not only was the presence of diabetes mellitus associated with complications during pregnancy but the degree of glycemic control also had an effect on the development of adverse events. Other than diabetes mellitus, the next most common endocrine disease encountered during pregnancy is thyroid disease, with hypothyroidism being more common than hyperthyroidism. Overt hypothyroidism has been shown to be associated with premature birth, low birth weight, pregnancy loss, reduction in offspring IQ, and the development of pregnancy-induced hypertension and, therefore, requires levothyroxine therapy throughout pregnancy. Hyperthyroidism is similarly associated with premature birth, low birth weight, pregnancy loss, hypertensive disorders during pregnancy, gestational diabetes mellitus, maternal heart failure, transient fetal hypothyroidism, neonatal Graves disease, and neonatal mortality. Additional endocrine diseases encountered in pregnancy include pheochromocytomas, prolactinomas, and primary hyperparathyroidism. Due to the rarity of these diseases, diagnosis is often delayed and can result in poor maternal and fetal outcomes. This review contains 6 figures, 5 tables, and 38 references. Key Words: diabetes, gestational, hyperglycemia, hyperparathyroidism, hyperthyroidism, hypothyroidism, pheochromocytoma, prolactinoma

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