Collision tumour of ovary: a rare combination of fibrothecoma with serous cystadenoma

A collision tumour is defined by presence of two separate tumors in one organ on gross, microscopic and immune-histochemical studies without any admixture. These tumors are reported from oesophagus, stomach, liver, lung and thyroid glands. Such tumors are extremely rare in ovary. In case of ovaries most common histological collision reported between mucinous tumors and teratomas. We are reporting a rare combination of fibrothecoma with serous cystadenoma in right ovary of a premenopausal woman. Both gynaecologist and pathologist should be aware of such combination. It is important to differentiate such tumors from malignant ovarian tumors. Frozen section and scrape cytology are important tools which help in appropriate management of such cases intraoperatively.

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Mucinous ovarian tumors and the importance of frozen section biopsy

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2018.08.337 ◽

2019 ◽

Vol 234 ◽

pp. e83

Author(s):

Konstantinos Ntzeros ◽

Nikolaos Thomakos ◽

Ioannis Papapanagiotou ◽

Maria Sotiropoulou ◽

Alexandros Rodolakis ◽

...

Keyword(s):

Frozen Section ◽

Ovarian Tumors ◽

Mucinous Ovarian Tumors

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Analysis of Metastatic Ovarian Tumors from Extragenital Primary Sites

Tumori Journal ◽

10.1177/030089160609200605 ◽

2006 ◽

Vol 92 (6) ◽

pp. 491-495 ◽

Cited By ~ 23

Author(s):

Taner Turan ◽

Burcu Aykan ◽

Sevgi Koc ◽

Nurettin Boran ◽

Gokhan Tulunay ◽

...

Keyword(s):

Tumor Marker ◽

Primary Tumor ◽

Frozen Section ◽

Ovarian Tumors ◽

Ca 125 ◽

Tumor Site ◽

Primary Tumor Site ◽

Adequate Treatment ◽

Presenting Symptoms ◽

Preoperative Serum

Aims and background The aim of this study was to evaluate patients with metastatic ovarian tumors from extragenital primary sites. Methods The medical records of 75 patients were reviewed retrospectively for age at diagnosis, presenting symptoms, preoperative tumor marker levels, preoperative diagnostic workup, operative technique, intraoperative evaluation, frozen-section and pathology results, laterality of metastasis, and primary tumor site. The specific impact of metastasis from colorectal and gastric primary sites on laterality, gross features and dimensions of ovarian mass, volume of ascites and tumor marker levels was investigated. Results Primary sites were stomach (37.3%), colorectal region (28%), lymphoma (12%), breast (6.7%), biliary system (2.7%), appendix (1.3%) and small intestine (1.3%). It was not possible to identify the primary tumor site in 8 (10.7%) patients. Bilateral metastasis was found in 86.4% patients; 42.7% of the metastatic ovarian tumors were Krukenberg tumors; 50.7% of the ovarian masses were solid. Frozen section was confirmed by postoperative pathological results in 98% of the patients. The mean preoperative serum levels of tumor markers were 298.7 U/mL, 178 U/mL and 113.3 U/mL for CA 125, CA 19-9 and CA 15-3, respectively. CA 125 levels were above 35 U/mL in 81.3% of the patients. The presence of ascites was more frequent in ovarian tumors originating from colorectal and gastric primaries. Conclusions Surgery is essential for the diagnosis of the primary tumor and necessary for relief of symptoms. The identification of the primary site is required to plan adequate treatment.

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Study of correlation of ultrasonography with surgical evaluation of adnexal masses: a prospective study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184155 ◽

2018 ◽

Vol 7 (10) ◽

pp. 4218

Author(s):

Urmila Tripathi ◽

Geetanjali Munda

Keyword(s):

Prospective Study ◽

Clinical Symptoms ◽

Histopathological Examination ◽

Abdominal Mass ◽

Age Groups ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Adnexal Masses ◽

Malignant Changes ◽

A Prospective Study

Background: Adnexal masses are one of the most common pathologies among women of all age groups. Ovarian tumors, alone, represent two thirds of these cases. Malignant ovarian tumors are the fourth most common cause of death in women. Accurate diagnosis is required foremost for proper treatment and management of the patients.Methods: A prospective study done on 100 patients with adnexal masses presenting to Department of Obstetrics and Gynecology at Kamla Raja Hospital, G.R.M.C, Gwalior from February 2015 to August 2016. Firstly, the cases were studied by ultrasonography then intraoperatively and simultaneous sampling for HPE done. The study included women with clinical symptoms of pain abdomen/ discomfort, bleeding per vaginum, abdominal mass was subjected to ultrasonography, diagnosed with adnexal mass. 100 indicated patients were taken for surgery and intraoperative tissue and fluid samples were taken and sent for HPE.Results: No discordance found regarding laterality of adnexal masses between ultrasonographical findings and surgical findings. 69% cases were devoid of any septation/locules/nodules. Most common pathology found to be ectopic pregnancy. Most common benign ovarian mass encountered was serous cystadenoma (31.1%) and malignant mass was serous adenocarcinoma (12.7%). Apart from 13 malignant adnexal masses, 2 adnexal masses had malignant changes found on histopathological examination. 11 cases were found to be of advanced stage on surgical findings, which then confirmed by HPE.Conclusions: There is positive correlation between ultrasonographical and surgerical evaluation of adnexal masses. Correlation of the lesion’s location and appearance at imaging with the surgical findings will aid in the detection of potential pathology reporting errors.

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Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i5.7868 ◽

2013 ◽

Vol 3 (5) ◽

pp. 397-402 ◽

Cited By ~ 1

Author(s):

D Ghartimagar ◽

A Ghosh ◽

G KC ◽

S Ranabhat ◽

OP Talwar

Keyword(s):

Ovarian Cancer ◽

Malignant Tumors ◽

Data Bank ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Benign Tumors ◽

Tertiary Referral ◽

Tertiary Referral Hospital ◽

Tertiary Referral Centre ◽

Epithelial Tumors

Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868

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The value of frozen section evaluation in the management of borderline ovarian tumors

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.92005 ◽

2011 ◽

Vol 7 (4) ◽

pp. 416 ◽

Cited By ~ 10

Author(s):

Emre Gultekin ◽

Basak Cingillioglu ◽

Muzaffer Sanci ◽

OzgeElmastas Gultekin ◽

Sevil Sayhan ◽

...

Keyword(s):

Frozen Section ◽

Ovarian Tumors ◽

Borderline Ovarian Tumors ◽

Section Evaluation

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An Evaluation of Frozen Section and Lymph Node Dissection Results for Mucinous Ovarian Tumors

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000001150 ◽

2018 ◽

Vol 28 (1) ◽

pp. 92-98 ◽

Cited By ~ 4

Author(s):

Marisa R. Moroney ◽

Miriam D. Post ◽

Amber A. Berning ◽

Jeanelle Sheeder ◽

Bradley R. Corr

Keyword(s):

Lymph Node ◽

Lymph Node Dissection ◽

Tumor Size ◽

Frozen Section ◽

Ovarian Tumors ◽

Node Dissection ◽

Cross Sectional ◽

Mucinous Histology ◽

Final Pathology ◽

Mucinous Ovarian Tumors

ObjectivesIntraoperative frozen section has greater than 90% accuracy for ovarian tumors; however, mucinous histology has been shown to be associated with increased frozen section inaccuracy. Recent data demonstrate that primary ovarian mucinous carcinomas have no lymph node involvement, even when extraovarian disease is present, and therefore may not require lymph node dissection. Our primary objective is to evaluate the accuracy of identifying mucinous histology on frozen section.Methods/MaterialsA cross-sectional review of mucinous ovarian tumors in surgical patients at one institution from 2006 to 2016 was performed. Cases reporting a mucinous ovarian tumor on frozen section or final pathology were identified. Frozen section results were compared with final diagnosis to calculate concordance rates. Analyses with χ2 and t tests were performed to identify variables associated with pathology discordance.ResultsA total of 126 mucinous ovarian tumors were identified. Of these, 106 were reported as mucinous on frozen section and 103 (97.2%) were concordant on final pathology. Discordant cases included 2 serous and 1 clear cell tumor. Among the 103 mucinous tumors, classification as malignant, borderline, or benign was concordant in 74 (71.8%) of 103 cases, whereas 22 (21.4%) of 103 were discordant and 7 (6.8%) were deferred to final pathology. Lymph node dissection was performed in 33 cases; the only case with lymph node metastasis was a gastrointestinal mucinous adenocarcinoma. Discordance between frozen section and final pathology was associated with larger tumor size and diagnosis other than benign: discordant cases had a mean tumor size of 21.7 cm compared with 14.4 cm for concordant cases (P < 0.001), and 93.5% of discordant cases were borderline or malignant, compared with 30.5% of concordant cases (P < 0.001).ConclusionsIntraoperative identification of mucinous histology by frozen section is reliable with a concordance rate to final pathology of 97.2%. No lymph node metastases were present in any malignant or borderline primary ovarian cases.

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Role of Intraoperative Scrape Cytology in Diagnosis of Palpable Breast Lump

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v17i2.39773 ◽

2019 ◽

Vol 17 (2) ◽

pp. 26-30

Author(s):

Shahe Systa Mosarrat ◽

Md Zillur Rahman ◽

M Shahab Uddin Ahamad ◽

Pradip Bhattacharjee ◽

Sayeeda Nasreen ◽

...

Keyword(s):

Malignant Tumors ◽

Diagnostic Yield ◽

Frozen Section ◽

Significant Proportion ◽

Standard Technique ◽

Definitive Treatment ◽

Histopathological Diagnosis ◽

Breast Lump ◽

Cross Sectional ◽

Scrape Cytology

Background: Diseases of the breast constitute a significant proportion of surgical cases and frequently, the need arises to distinguish benign from malignant lesions prior to definitive treatment. So far, Frozen Section (FS) is the standard technique with high level of validity. However, intraoperative scrape cytology can be adopted when special facilities of FS are not available. Methods: This study designed with the aim to evaluate the value of Intraoperative Scrape Cytology (IOSC) in providing rapid and accurate diagnosis for breast lump and to compare its diagnostic yield with that of paraffin sections. This cross sectional descriptive study was carried out in the Department of Pathology, Chittagong Medical College in collaboration with Department of Surgery of this institution from October 2013 to September 2014. The study conducted on 123 patients with breast lumps who underwent operative treatment. Scrapings were taken from each specimen before formalin fixation and stained by rapid Papanicolaou staining. In each case their accuracy was compared to histopathological diagnosis. Statistical analysis done employing c2 test. Results: Out of 123 cases studied, 122 could be correctly differentiated into benign and malignant tumors with an accuracy rate of 99.19%. Conclusion: Intraoperative Scrape Cytology (IOSC) is a simple, accurate, rapid and cost-effective diagnostic tool, not requiring specific instruments in contrast to frozen section, can be used peroperatively for both diagnosis and management of breast lump. Chatt Maa Shi Hosp Med Coll J; Vol.17 (2); Jul 2018; Page 26-30

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Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_117_18 ◽

2019 ◽

Vol 11 (01) ◽

pp. 075-081 ◽

Cited By ~ 1

Author(s):

Neha Gupta ◽

Mahima Yadav ◽

Vikas Gupta ◽

Deepshikha Chaudhary ◽

Shashikant C. U. Patne

Keyword(s):

Germ Cell ◽

Who Classification ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Germ Cell Tumors ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Care Hospital ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

Abstract BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

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