scholarly journals Study on umbilical cord arterial blood gas analysis and cord blood lactate levels as predictors for adverse neonatal outcome: an observational study

2018 ◽  
Vol 7 (4) ◽  
pp. 1494 ◽  
Author(s):  
Suman Shivanagouda Patil ◽  
Sukanya . ◽  
Suman Rath ◽  
Carolin Elizabeth George
Keyword(s):  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Umbilical Artery ◽  
Neonatal Outcome ◽  
Serum Lactate ◽  
Adverse Neonatal Outcome ◽  
Lactate Levels ◽  
Blood Lactate Levels

Background: Perinatal asphyxia is a major cause of neonatal and childhood morbidity and mortality. Electronic foetal monitoring is used routinely to know the condition of the baby during Intrapartum period. Normal trace correlates highly with absence of acidemia at birth. Abnormal trace needs further evaluation. In order to better define the metabolic status of the new born, umbilical lactate levels have been measured. Objectives of this study were to determine the validity of umbilical cord blood lactate levels in predicting the adverse early neonatal outcome in babies with intrapartum foetal distress and to compare the validity of umbilical cord blood lactate and umbilical artery pH in predicting adverse neonatal outcome in babies with intrapartum foetal distress.Methods: 295 pregnant women with abnormal CTG in active labour were subjected for estimation of cord blood lactate and umbilical artery pH immediately after delivery and were compared in predicting adverse neonatal outcome.Results: In the present study specificity of serum lactate (97.7%) and umbilical artery pH (95.97%) was almost similar in babies with Apgar <7 at 1 minute and 5 minutes, but sensitivity of serum lactate (23.14%) and cord ph (31.4%) was less in babies with Apgar score ≤7 at 1 minute. Area under ROC showed serum lactate is more accurate in predicting adverse neonatal outcome compared to umbilical artery pH.Conclusions: Umbilical cord blood lactate is more specific than umbilical artery pH in predicting adverse neonatal outcome. Area under ROC (at 95th percentile) shown serum lactate is more accurate in predicting adverse neonatal outcome compared to umbilical artery pH at birth.

Umbilical Cord Blood Lactate Levels in Newborns with Perinatal Asphyxia

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Perinatal Asphyxia ◽  
Cutoff Point ◽  
Lactate Levels ◽  
Blood Lactate Levels

Objectives: This present study аims to evаluаte whether increаsing levels of cord blood lаctаte is аssociаted with perinаtаl аsphyxiа by using the commonly prаctised АPGАR score аs the gold stаndаrd. Methods: We performed а descriptive cross sectionаl study between Аpril 2014 аnd Аpril 2015 аt Hue Medicаl University Hospitаl, Vietnаm. 106 newborn bаbies (41 аsphyxiааnd 65 normаl bаbies) were included in the study. Umbilicаl cord blood is sаmpled for lаctаte аnаlysis. Results: Umbilicаl cord blood lаctаte levels were significаntly higher аmong infаnts born with аsphyxiа (meаn 7.71± 0.27, rаnge 4.74 – 11.96) compаred to thаt with normаl infаnts (meаn 5.56± 1.71, rаnge 1.32 – 10.82). Оverаll аccurаcy wаs very gооd, with аreа under RОC curve оf 0.803 (95% CI: 0.750–0.936). The optimаl cutoff point for umbilicаl cord blood lаctаte level of 6.97 mmol/l to diаgnose аsphyxiа hаd а sensitivity 58.5% (95% CI: 42.1 - 73.7), specificity 89.2% (95% CI: 79.1 - 95.6), +ve LR (likelihood rаtio) 5.44, -ve LR 0.46. Conclusion: Umbilicаl cord blood lаctаte is very good in confirming the diаgnosis of asphyxia and following up in newborn bаbies.

scholarly journals Accuracy of a hand-held lactate meter in measuring umbilical cord blood lactate at all lactate levels

2014 ◽  
Vol 04 (01) ◽  
pp. 47-53 ◽  
Author(s):  
Seng C. Chua ◽  
May Y. W. Wong ◽  
Tina Y. Su ◽  
Mifanwy Reece
Keyword(s):  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Lactate Levels

Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice

Pharmacology ◽  
2017 ◽  
Vol 100 (5-6) ◽  
pp. 218-228 ◽  
Author(s):  
Mu-chao Wu ◽  
Wei-ran Ye ◽  
Yi-jia Zheng ◽  
Shan-shan Zhang
Keyword(s):  
Blood Lactate ◽  
Cell Mass ◽  
Lactate Production ◽  
Beta Cell Mass ◽  
Serum Lactate ◽  
Blood Levels ◽  
Anti Inflammatory ◽  
Lactate Levels ◽  
Blood Lactate Levels

Metformin (MET) is the first-line drug for treating type 2 diabetes mellitus (T2DM). However, MET increases blood lactate levels in patients with T2DM. Lactate possesses proinflammatory properties and causes insulin resistance (IR). Oxamate (OXA), a lactate dehydrogenase inhibitor, can decrease tissue lactate production and blood lactate levels. This study was conducted to examine the effects of the combination of OXA and MET on inflammation, and IR in diabetic db/db mice. Supplementation of OXA to MET led to lowered tissue lactate production and serum lactate levels compared to MET alone, accompanied with further decreased tissue and blood levels of pro-inflammatory cytokines, along with better insulin sensitivity, beta-cell mass, and glycemic control in diabetic db/db mice. These results show that OXA enhances the anti-inflammatory and insulin-sensitizing effects of MET through the inhibition of tissue lactate production in db/db mice.

Umbilical cord blood lactate: A valuable tool in the assessment of fetal metabolic acidosis

2008 ◽  
Vol 139 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Anne Cathrine Gjerris ◽  
Jette Stær-Jensen ◽  
Jan Stener Jørgensen ◽  
Thomas Bergholt ◽  
Carsten Nickelsen
Keyword(s):  
Metabolic Acidosis ◽  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

DYNAMICS OF INDICES OF LINOLEIC AND ARACHIDONIC FATTY ACIDS IN CORD BLOOD OF NEWBORNS FROM MOTHERS WITH CYTOMEGALOVIRUS INFECTION

2016 ◽  
Vol 1 (60) ◽  
pp. 75-79
Author(s):  
Дорофиенко ◽  
Nikolay Dorofienko
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cytomegalovirus Infection ◽  
Umbilical Artery ◽  
Control Group ◽  
Gas Liquid Chromatography ◽  
Igg Antibodies

Due to the broad spectrum of influence of polyunsaturated fatty acids of ω-6 family on the development of the fetus and newborn child, the composition of arachidonic fatty acid and its predecessor linoleic fatty acid were studied in blood of the umbilical cord blood of newborns from mothers with chronic reactivation of cytomegalovirus infection. 82 newborns were examined; among them there were 42 infants (the main group) from mothers who had cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus was 1:1600) in the III trimester. The control group included 42 newborns from healthy women. In the umbilical cord blood of newborns the contents of arachidonic and linoleic fatty acids were identified with gas-liquid chromatography. The study found out that the reactivation of cytomegalovirus infection in the mother (titer of IgG antibodies to cytomegalovirus 1:1600) leads to an increase in the content of linoleic acid by 56% (p&#60;0.001) and of the predecessor of pro-inflammatory eicosanoids - arachidonic acid by 34% (p&#60;0.001) in the cord blood of newborns; it is one of the causes of disturbance of the structural and functional organization of the umbilical artery vessels. Identified changes in umbilical cord blood and umbilical artery endothelium can cause disturbances of the elastic properties of vessels, stagnation and thrombosis of blood vessels and, consequently, disturbances of blood flow between mother and fetus, which can then serve as a factor in the development of fetal hypoxia.

Umbilical cord blood lactate in normal infants: Comparison between two methods of measurement

2001 ◽  
Vol 37 (1) ◽  
pp. 24-27 ◽  
Author(s):  
JKH Sinn ◽  
J Lloyd ◽  
DA Todd ◽  
R Lazarus ◽  
A Maesel ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Methods Of Measurement
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