scholarly journals Effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in pregnancy

2018 ◽  
Vol 7 (5) ◽  
pp. 1908
Author(s):  
Devdatt Laxman Pitale
Keyword(s):  
Side Effects ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Age Group ◽  
Oral Iron Therapy ◽  
The Mean ◽  
Anaemia In Pregnancy ◽  
In Pregnancy

Background: Anaemia in pregnancy is very common throughout our country impacting both mother and the newborn. The most common cause of anaemia in pregnancy is iron deficiency. The increased prevalence of iron deficiency anaemia amongst the pregnant women, especially in developing countries is a major cause of significant maternal morbidity and mortality. Intolerance to oral iron, inadequate absorption, and side effects leading to poor compliance are the major shortcomings in oral iron therapy. These factors are significant especially in anaemia near term. To overcome all these limiting factors associated with oral iron therapy, parenteral iron therapy is preferred. Aim of this study was to study effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in pregnancy.Methods: This prospective study was taken up to compare the effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in 30 antenatal women attending antenatal outpatient Department of Obstetrics and Gynaecology belonging to gestational age group of 28-34 weeks with anaemia in pregnancy.Results: Majority of pregnant women belonged to age group of 22-25 years.67% were primigravidas. The period of gestation varied from 28-34 weeks. In this study, the mean baseline haemoglobin was 8.4 g/dl before start of treatment and after iv iron sucrose treatment haemoglobin showed a mean value of 10.8g/dl. The mean baseline MCV was 70 fl/cell. Post treatment MCV after 4 weeks showed a significant mean rise of 12 fl/cell in the present study with no major side effects.Conclusions: Intravenous iron sucrose is highly effective over oral iron therapy for anaemia in pregnancy. It enables rapid correction of anaemia with minimal side effects.

scholarly journals Efficacy and safety of high dose accelerated intravenous iron sucrose in patients of iron deficiency anemia

2017 ◽  
Vol 5 (8) ◽  
pp. 3359
Author(s):  
Muzafar Naik ◽  
Tariq Bhat ◽  
Ummer Jalalie ◽  
Arif Bhat ◽  
Mir Waseem ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
High Dose ◽  
Oral Iron Therapy ◽  
The Mean

Background: Low dose (200 mg) extended Intravenous iron sucrose remains the most common treatment option in patients who are intolerant to oral iron therapy in patients with Iron deficiency anemia (IDA). The objective of this study was to evaluate the efficacy and safety of high dose accelerated intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemiaMethods: One hundred adult patients with iron deficiency anemia, who had intolerance or showed no effect with oral iron therapy, received daily doses of 500 mg of intravenous iron sucrose until the hemoglobin level was corrected or until receiving the total dose of intravenous iron calculated for each patient.Results: The mean and median Hb (g/dL) 6.47±1.656 and 6.6 (2) at baseline, 9.61±1.629 and 9.6 (2) at 2 weeks of treatment, 11.85±1.277 and 12 (1) at 4 weeks of treatment respectively. The mean rise of Hb was 3.13±1.41 and 5.37±1.50 after 2 and 4 weeks of treatment respectively (p<0.000). A total of 303 intravenous infusions of iron sucrose were administered and iron sucrose was generally well tolerated with twenty-six patients developing mild and one patient developing moderate adverse drug reactions. There was no serious adverse event recorded.Conclusions: Accelerated high dose intravenous iron sucrose is a safe and cost effective option minimizing frequent hospital visits in the treatment of adults with iron deficiency anemia who are intolerant or lack satisfactory response to oral iron therapy.

scholarly journals Iron Sucrose Versus Oral Iron Therapy in Pregnancy Anemia

2012 ◽  
Vol 37 (4) ◽  
pp. 214 ◽  
Author(s):  
Lavanya Rai ◽  
Syal Neeru ◽  
NSreekumaran Nair
Keyword(s):  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy ◽  
In Pregnancy

Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy

2012 ◽  
Vol 58 (4) ◽  
pp. 655-655
Author(s):  
Shelley E. Crary ◽  
Katherine Hall ◽  
George R. Buchanan
Keyword(s):  
Iron Deficiency ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy

scholarly journals A study on management of maternal anemia with infusion of intravenous iron sucrose and its outcome in management of anemia

2018 ◽  
Vol 8 (1) ◽  
pp. 39
Author(s):  
Uma Maheswari R. ◽  
R. Veerakumaran
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Hematological Parameters ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Iron Group ◽  
Moderate Anemia

Background: In India, women become pregnant with low baseline hemoglobin level resulting in high incidence of moderate to severe anemia in pregnancy where oral iron therapy cannot meet the requirement. Pregnant women with moderate anemia are to be treated with parenteral iron therapy. The aim of the study is to the infusion of intravenous iron sucrose and its outcome in the management of anemia.Methods: Totally 100 pregnant females were included in the study. The study period was from January 2018-July 2018 at vanavil medical center in Chennai. 50 Patients of Group A was given oral iron tablets containing100mg of elemental iron. 50 patients of Group B was given a total of 1000 mg of intravenous iron sucrose divided into five doses of 200 mg each at weekly intervals. Estimation of hemoglobin was started 4 weeks after commencement of iron therapy and then repeated every 4 weeks till 36 weeks of gestation, pre-delivery and postpartum.Results: Target hemoglobin levels were achieved in 4 weeks’ time in 19 (76%) patients in the iron sucrose group as compared to 08 (32%) of patients in the oral iron group. There was a significant improvement in the various hematological parameters in iv sucrose group as compared to patients in the oral iron group. There were no significant allergic reactions in iv sucrose group.Conclusions: Our results showed that intravenous iron sucrose therapy was effective to treat moderate anemia in pregnant women. Intramuscular preparations are known to be associated with local side-effects. Iron sucrose complex iv therapy was with negligible side effects. It caused a rapid rise in hemoglobin level and the replacement of stores was faster. Long term comparative studies are required to assess if they can be used at a peripheral level.

scholarly journals Comparison of efficacy and safety of injectable iron sucrose with oral ferrous ascorbate in the treatment of anaemia in pregnancy

2019 ◽  
Vol 8 (4) ◽  
pp. 1277
Author(s):  
Sunitha H. B. ◽  
Sunil Kumar G. S.
Keyword(s):  
Hemoglobin Concentration ◽  
Intravenous Iron ◽  
Significant Rise ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Efficacy And Safety ◽  
Suitable Alternative ◽  
Anaemia In Pregnancy ◽  
Group B ◽  
In Pregnancy

Background: Anemia due to Iron deficiency is the commonest malnutrition disorder seen throughout the world and in India. It is also responsible for increased incidence of premature births, low birth weight babies and high perinatal mortality. Hence, the present study undertaken to assess efficacy and safety of injectable iron sucrose with oral ferrous ascorbate.Methods: 100 pregnant women, between gestational age 14 and 28 weeks were divided randomly into two groups i.e. group A consists of oral iron, a total of 200 mg of elemental iron per day, two 100mg iron tablets per day and group B consists of iron sucrose at the rate of 200mg on alternate OPD day. Informed consent was taken from each patient.Results: The percentage rise in hemoglobin at fourth and eighth weeks of treatment was statistically significant when compared to the baseline. Statistically significant rise in hemoglobin, PCV and ferritin levels were found at fourth and eighth weeks in IV group when compared to oral group.Conclusions: This study concluded that intravenous iron sucrose is safe and highly efficacious for the treatment of anemia in pregnancy. It restores iron stores more promptly. Iron sucrose therapy is more effective in achieving the optimum results, an increase in hemoglobin concentration, PCV levels and an increase in ferritin levels also. Therefore, it is a suitable alternative to oral iron with minimal side effects in those patients who cannot tolerate oral iron therapy. 

scholarly journals Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy

2010 ◽  
Vol 56 (4) ◽  
pp. 615-619 ◽  
Author(s):  
Shelley E. Crary ◽  
Katherine Hall ◽  
George R. Buchanan
Keyword(s):  
Iron Deficiency ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy
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