scholarly journals Successful treatment of clear cell carcinoma of ovary during pregnancy: a case report

2021 ◽  
Author(s):  
Preethi Ashok ◽  
Kalaichelvi Kannan
Keyword(s):  
Cell Carcinoma ◽  
Successful Treatment ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Fetal Monitoring ◽  
Post Surgery ◽  
Malignant Ovarian Tumor ◽  
Clear Cell Ovarian Carcinoma ◽  
Cystic Masses

The incidence of malignant ovarian tumor is rare during pregnancy. Most women hope to maintain the pregnancy and preserve fertility thus increasing the need for standard guidelines regarding surgery and chemotherapy for safe oncologic and fetal outcomes. Here we present a 30-years-old primigravida, diagnosed with bilateral ovarian mass during routine ultrasound imaging at 8 weeks of gestation. CA125 was 14.2 U/ml. MRI pelvis taken at 13 weeks showed bilateral complex cystic masses with internal septations. The patient underwent bilateral salphingo-oopherectomy and infracolic omentectomy during 18th week of gestation, the histopathology showing clear cell carcinoma with capsular invasion and microscopic omental deposit thus staged as IIIA. She was planned for adjuvant chemotherapy comprising of paclitaxel and carboplatin during the 21st week along with serial ultrasounds for fetal monitoring. After 5 cycles, at 37 weeks of gestation, she was taken up for elective LSCS followed by completion of surgery for ovarian malignancy, that is, hysterectomy with bilateral pelvic lymphadectomy. Endometrium showed gestational changes with all lymph nodes being negative for tumor deposits. A healthy male child weighing 3.4 kg was delivered. She was given 6th cycle of chemotherapy post-surgery and two years later, mother and baby are doing well and on regular follow up. Thus, the successful treatment of clear cell ovarian carcinoma in this woman with safe pregnancy outcomes can be attributed to timely diagnosis and feasibility of surgery and chemotherapy during second trimester.

scholarly journals Case Report: A rare case of renal-type clear cell carcinoma of the prostate

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 475
Author(s):  
Muhammad Asykar Palinrungi ◽  
Rina Masadah ◽  
Khoirul Kholis ◽  
Syakri Syahrir ◽  
Syarif Syarif ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Pubic Bone ◽  
Post Surgery ◽  
Urinary Tract Symptoms ◽  
Computed Tomography Scans

Renal-type clear cell carcinoma (RTCCC) of the prostate is a rare form of kidney cancer that is infrequently reported in the literature. Here we describe the case of an 81-year-old male patient with a hard, immovable mass on his enlarged prostate, which was discovered through a digital rectal examination. His prostate-specific antigen (PSA) level was 23.01 ng/ml, and bone multi-slice computed tomography scans revealed several osteoblastic lesions on the inferior ramus of his bilateral pubic bone. Tissue recovered during the trans urethral resection of the prostate was indicative of RTCCC with typical prostatic adenocarcinoma (Gleason score 3 + 4 = 7). Concerning treatment course, bilateral subcapsular orchiectomy was chosen over medical hormonal therapy. Upon follow-up 12 months post-surgery, his lower urinary tract symptoms were nearly resolved and his serum PSA level had decreased to 3.2 ng/ml. Accurate RTCCC diagnosis remains a pressing concern that warrants further investigation to optimize treatment selection and patient outcome.

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach

2015 ◽  
Vol 129 (S2) ◽  
pp. S95-S97 ◽  
Author(s):  
T Nakashima ◽  
R Yasumatsu ◽  
M Yamauchi ◽  
S Toh ◽  
T Nakano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Good Prognosis ◽  
Salivary Gland Neoplasm ◽  
Hyalinizing Clear Cell Carcinoma

AbstractBackground:Hyalinizing clear cell carcinoma is a rare minor salivary gland neoplasm. The treatment of choice is surgical resection with or without post-operative radiotherapy. This tumour often demonstrates a good prognosis.Case report:We report a case of hyalinizing clear cell carcinoma arising in the nasopharynx. A 27-year-old female presented with progressive hearing disturbance and tinnitus. On examination, an expansile mass was observed in her nasopharynx. Biopsy was performed and the pathology results returned as clear cell carcinoma.Results and conclusion:Surgical resection was performed trans-orally accompanied by trans-palatal approach. She has no recurrence during more than two years of follow up.

scholarly journals A Rare Case of Clear Cell Carcinoma, Müllerian Type in the Renal Pelvis of a 21-Year-Old Woman

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Diandra Perez ◽  
Rana Naous
Keyword(s):  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Neoplastic Cells ◽  
Primary Location ◽  
Foamy Macrophages ◽  
Vacuolated Cytoplasm

Clear Cell Carcinomas of Müllerian origin are extremely rare within the upper urinary system. Their morphology is identical to that of the Clear Cell Carcinomas of the female genital tract. When they arise in the urinary tract, it is thought to be due to ectopic Müllerian embryogenesis. Here, we present a case of a 21-year-old woman with a Clear Cell Carcinoma, Müllerian type, arising from the renal pelvis. Histologically, it consisted of tubulopapillary architecture with associated foamy macrophages and a mucinous background. The neoplastic cells exhibited variably sized round nuclei with prominent nucleoli, eosinophilic to vacuolated cytoplasm with occasional intracytoplasmic mucin vacuoles, and a hobnail appearance. Immunohistochemical stains showed that the neoplastic cells were positive for Pax-8, p53, CK7, HMWK 903, and INI-1 and focally positive for p504s (AMACR). The neoplastic cells were negative for GATA-3, CK5/CK6, p63, CK20, and CDX-2 immunostains, ruling out urothelial or enteric phenotype. Additional immunostains performed by an outside institution showed that the neoplastic cells were positive for HNF-1β. The overall morphology and immunophenotype were consistent with Clear Cell Carcinoma of Müllerian origin arising from the renal pelvis. Follow-up revealed no metastasis or other tumor sites, supporting that this was the primary location.

scholarly journals An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Goran Gudelj ◽  
Tena Simunjak ◽  
Marica Zizic ◽  
Boris Simunjak ◽  
Martin Jurlina
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Tumor Location ◽  
Total Recovery ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Left Posterior

Abstract Hyalinizing clear cell carcinoma (HCCC) is a rare, predominantly minor salivary gland tumor. Most of these tumors occur in the oral cavity, mainly the palate and tongue. Primary localization of the tumor in the region of the nasal cavity and paranasal sinuses is extremely rare and, with only a few cases reported in the literature so far. We present an extremely rare case of a 61-year-old woman with hyalinizing clear cell carcinoma (HCCC), occupying the left posterior nasal and nasopharyngeal cavity, as a primary tumor location. The patient total recovery was uneventful, and she is now free of disease at three years postoperative follow-up.

Nine Years of Follow-Up of a Patient with Thyroid Metastasis from Clear Cell Carcinoma: A Case Report

2011 ◽  
pp. P3-646-P3-646
Author(s):  
Jordana B Daltrozo ◽  
Camila G Pereira ◽  
Marcelo F Ronsoni ◽  
Marisa H Coral ◽  
Alexandre Hohl
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Thyroid Metastasis

Neoadjuvant Chemotherapy Followed by Cesarean Radical Hysterectomy in a Triplet Pregnancy Complicated by Clear Cell Carcinoma of the Cervix: A Case Presentation and Literature Review

2012 ◽  
Vol 22 (7) ◽  
pp. 1198-1202 ◽  
Author(s):  
Ali Ayhan ◽  
Polat Dursun ◽  
Burcu Kisa Karakaya ◽  
Ozlem Ozen ◽  
Cagla Tarhan
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Radical Hysterectomy ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Term Pregnancy ◽  
Triplet Pregnancy

ObjectiveTo report a triplet pregnancy complicated by clear cell cervical carcinoma that was managed using neoadjuvant chemotherapy followed by caesarean radical hysterectomy.Patient HistoryA 26-year-old woman had a diagnosis of cervical clear cell carcinoma, which was International Federation of Gynecology and Obstetrics stage IB1, at 18 weeks of gestation during a triplet pregnancy. Owing to the patient’s strong desire for full-term pregnancy, 3 cycles of neoadjuvant chemotherapy was administered after magnetic resonance imaging evaluation of the tumor. The patient underwent cesarean delivery and radical hysterectomy at gestational week 32. The hysterectomy specimen revealed stage IB1 clear cell adenocarcinoma of the cervix. The neonates and the mother did not have any complications related to the treatment during 36 months of follow-up.ConclusionTo the best of our knowledge, this is the first report of a triplet pregnancy complicated by cervical clear cell carcinoma that was successfully treated with neoadjuvant chemotherapy and cesarean radical hysterectomy. Our experience and literature review suggest that neoadjuvant chemotherapy for cervical carcinoma diagnosed during pregnancy is associated with excellent oncologic and fetal outcome; therefore, it may be considered as a temporary fertility-sparing approach in selected patients with a strong desire for full-term pregnancy. Nonetheless, additional research and long-term follow-up are needed to reach a more definitive conclusion.

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