scholarly journals Comparison of efficacy of injection ferric carboxymaltose and iron sucrose in moderate anaemia in pregnancy

2021 ◽  
Vol 10 (7) ◽  
pp. 2794
Author(s):  
Kishna Ram ◽  
Kavita Arya ◽  
Nupur Hooja ◽  
Neha Singh ◽  
Aditi Jaiswal
Keyword(s):  
Intravenous Iron ◽  
Gastrointestinal Disorder ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Ferric Carboxymaltose ◽  
Group A ◽  
High Doses ◽  
Anaemia In Pregnancy ◽  
Group B ◽  
Group Target

Background: Prevalence of anaemia in pregnant women is 14% in developed and 58-89.6% in pregnant Indian women. Parenteral iron is seems to be an option in the treatment of moderate iron deficiency anaemia which allow high doses of iron to be administered rapidly, in those who are intolerant to oral iron, have  poor compliance to oral iron or gastrointestinal disorder. The objective was to compare the efficacy of newer drug, inravenous ferric carboxymaltose (FCM) with intravenous iron sucrose.Methods: Group A were given injection FCM and group B were given injection iron sucrose. FCM was given in one or two sittings depending on iron requirement and iron sucrose was given in divided doses. Haemogram was done at baseline and on day 3 and 21 and at 12 weeks. All the observations were tabulated and analysed.Results: The mean rise in haemoglobin values from baseline in the FCM group was 0.20±0.06 at 3rd day, 2.03±0.47 at 3 weeks, 3.86±0.53 at 12 weeks compared to iron sucrose group, which was 0.11±0.08 at 3rd day, 1.51±0.39 at 3 weeks, and 3.22±0.54 at 12 weeks, which was statistically significant and showed that the haemoglobin levels were increased more in FCM group. Target haemoglobin was achieved in 92% women in FCM group and 78% women in iron sucrose group.Conclusions: Women in the FCM group achieved significantly higher haemoglobin level than in iron sucrose group. It was given in fewer sittings, hence was more convenient with better efficacy.

scholarly journals Comparative study of efficacy and safety of intravenous ferric carboxymaltose versus iron sucrose in treatment of post-partum anemia

2021 ◽  
Vol 10 (9) ◽  
pp. 3531
Author(s):  
Ragvi Raman ◽  
Jayanthy T. ◽  
Apoorva Asranna
Keyword(s):  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Post Treatment ◽  
Iron Sucrose ◽  
Ferric Carboxymaltose ◽  
Postpartum Women ◽  
Deficiency Anaemia ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Ferric carboxymaltose has been recently introduced for the treatment of anaemia. The present study was planned to compare the efficacy, tolerability and safety of intravenous ferric carboxymaltose with intravenous iron sucrose in the treatment of iron deficiency anaemia among postpartum women.Methods: A total of 60 postpartum women with haemoglobin levels between 7-10 g/dl were randomized into two groups: 30 in group A (received iron carboxymaltose) and 30 in group B (Received iron sucrose). Haemoglobin and serum ferritin levels were done on day 0 and after 6 weeks.Results: The post treatment haemoglobin levels were found to be 10-10.9 g/dl in 66.7% of women in group A and 63.3% in group B. The mean post treatment haemoglobin levels in group A was 9.97±0.3 g/dl and in group B was 10.9 g/dl (p<0.001). The mean increase in haemoglobin levels post treatment were significantly high in group B (2.1±0.5 gm%) compared to group A (1.3±0.5 gm%). The mean post treatment S. Ferritin levels in group A was 91.2±25.8 and in group B was 126.5±23.2 gm%. The mean increase in S. Ferritin levels post treatment were significantly high in group B (96.9±23.3) compared to group A (62.7±22.6) (p<0.001).Conclusions: Intravenous iron carboxymaltose is more effective and better tolerated in the treatment of iron deficiency anaemia among postpartum women compared to intravenous iron sucrose.

scholarly journals Comparison of efficacy and safety of injectable iron sucrose with oral ferrous ascorbate in the treatment of anaemia in pregnancy

2019 ◽  
Vol 8 (4) ◽  
pp. 1277
Author(s):  
Sunitha H. B. ◽  
Sunil Kumar G. S.
Keyword(s):  
Hemoglobin Concentration ◽  
Intravenous Iron ◽  
Significant Rise ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Efficacy And Safety ◽  
Suitable Alternative ◽  
Anaemia In Pregnancy ◽  
Group B ◽  
In Pregnancy

Background: Anemia due to Iron deficiency is the commonest malnutrition disorder seen throughout the world and in India. It is also responsible for increased incidence of premature births, low birth weight babies and high perinatal mortality. Hence, the present study undertaken to assess efficacy and safety of injectable iron sucrose with oral ferrous ascorbate.Methods: 100 pregnant women, between gestational age 14 and 28 weeks were divided randomly into two groups i.e. group A consists of oral iron, a total of 200 mg of elemental iron per day, two 100mg iron tablets per day and group B consists of iron sucrose at the rate of 200mg on alternate OPD day. Informed consent was taken from each patient.Results: The percentage rise in hemoglobin at fourth and eighth weeks of treatment was statistically significant when compared to the baseline. Statistically significant rise in hemoglobin, PCV and ferritin levels were found at fourth and eighth weeks in IV group when compared to oral group.Conclusions: This study concluded that intravenous iron sucrose is safe and highly efficacious for the treatment of anemia in pregnancy. It restores iron stores more promptly. Iron sucrose therapy is more effective in achieving the optimum results, an increase in hemoglobin concentration, PCV levels and an increase in ferritin levels also. Therefore, it is a suitable alternative to oral iron with minimal side effects in those patients who cannot tolerate oral iron therapy. 

scholarly journals A comparative study of oral iron and intravenous iron in iron deficient antenatal mothers

2018 ◽  
Vol 7 (5) ◽  
pp. 1848
Author(s):  
Suganya G. ◽  
D. Vimala
Keyword(s):  
Pregnant Women ◽  
Carbonyl Iron ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy ◽  
Iron Deficient ◽  
Group A ◽  
Group B

Background: The aim of the study is to compare the efficacy, tolerance and compliance between oral iron and intravenous infusion of iron in iron deficient antenatal mother.Methods: This is a prospective randomised clinical and interventional study in the department of Obstetrics and Gynaecology in Vinayaka Mission Kirupananda Variyar Medical College and Hospital. The antenatal women attending the antenatal op were screened for Hb status. Those antenatal women of gestational age 16-34 weeks with Hb level between 7-10g% and diagnosed to have iron deficiency anemia by peripheral smear and serum ferritin were included in this study after getting informed consent. The total numbers of 100 mothers were allotted into two major groups, group A and group B of 50 subjects each. Group A: 50 pregnant women given oral iron supplementation (carbonyl iron 100 mg twice a day). Group B: 50 pregnant women given intravenous iron sucrose therapy after calculating the total iron requirement. The rise in hemoglobin in both the groups were comparedResults: In this study the mean rise of hemoglobin in carbonyl iron was 0.914±0.20 gm% whereas in iron sucrose group was 2.43±0.20gm%. This showed that iron sucrose (i.v) had better rise in Hb than carbonyl iron (oral).Conclusions: The present study revealed that intravenous iron sucrose therapy was bettertolerated with higher increase in mean haemoglobin compared to oral iron therapy. There were no serious side effects with intravenous iron sucrose therapy. Intravenous iron sucrose is a good substitute to oral iron therapy in moderate anaemia.

scholarly journals IRON DEFICIENCY ANEMIA

2007 ◽  
Vol 14 (02) ◽  
pp. 263-265
Author(s):  
RAHEELA FARHAT ◽  
DR. MAHNAAZ ROOHI
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Deficiency Anemia ◽  
Safety And Efficacy ◽  
Deficiency Anaemia ◽  
Group A ◽  
Group B

Objective: To evaluate the safety and efficacy of intra venous iron sucrose(venofer) as comparedto oral iron in treatment of iron deficiency anaemia during pregnancy. Study Design: Prospective study. Pregnantwomen with iron deficiency anaemia were selected from ante natal clinic. Patients were divided into two groups. GroupA: These patients were given oral iron. Group B: These patients were given intravenous sucrose. All patients wereevaluated for adverse effects, clinical and laboratory response >. Results: Intravenous group achieved a higher Hblevel in a shorter period. Group B showed no major side effects while (80%) of patients in Group A developedgastrointestinal symptoms. Conclusion: Intravenous iron sucrose is safe and effective in treatment of iron deficiencyanemia during pregnancy.

scholarly journals Comparison of ferric carboxymaltose versus Iron Sucrose for treatment of iron deficiency anemia in pregnancy.

2021 ◽  
Vol 28 (04) ◽  
pp. 481-484
Author(s):  
Hira Jamal ◽  
Humaira Zafar ◽  
Mubashra Naz ◽  
Umber Fatima ◽  
Anees Fatima
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Intravenous Iron ◽  
Iron Sucrose ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
P Value ◽  
Iron Treatment ◽  
Group A ◽  
Group B

Objective: To compare the mean increase in hemoglobin level with ferric carboxymaltose injection and iron sucrose injection for the management of the pregnant females presenting with iron deficiency anemia. Study Design: Randomized Controlled Trial. Settings: Department of Obstetrics and Gynecology Madina Teaching Hospital affiliated with University medical and Dental College Faisalabad. Period: July 2019 to December 2019. Material & Method: A total number of 100 patients presented in OPD satisfying the selection criteria were enrolled in the study after permission from ethical committee. On enrollment, a detailed clinical history which include previous iron treatment including and chronic medical disorders was taken. Clinical examination was done. Investigations for anemia include hemoglobin, reticulocyte count, peripheral film and red cell indices, serum ferritin level and Hb electrophoresis if indicated. The patients were randomly divided in two groups. In group A, females were given ferric carboxymaltose and in group B, females were given iron sucrose. After calculating the total iron deficit, patients in group A were given intravenous FCM. Patients in group B were given IS. Follow up of the patient was done after 3 weeks of intravenous iron treatment. The baseline Hb and values after 3 weeks of intravenous iron treatment were compared between the FCM and IS groups and increase in Hb level calculated as mean and SD. Both groups were analyzed for rise in Hb level by using independent sample t test. P value < 0.05 was taken as significant. Results: A total 100 pregnant female were found eligible for study, and were randomized into two groups of 50 each. Mean increase in hemoglobin level with ferric carboxymaltose and iron sucrose was evaluated, it shows that baseline Hb was 8.84±0.68 in Group A and 8.78 ±0.76 in Group B, P value was 0.67, after treatment Hb was 12.02±0.89 in Group A and 10.92 ±0.99 in Group B. Mean increase was 3.18 ±0.60 in Group A and 2.14±0.81 in Group B. P value was 0.001. Conclusion: Ferric carboxymaltose significantly increase Hb level and restores the iron stores as compare to iron sucreose. FCM is safe and effective intravenous treatment for iron deficiency anemia in pregnancy. FCM has the advantages of single large dose administration and fewer hospital visit. FCM is most suitable drug for the treatment of patients with IDA who required quick replenishment of iron stores.

scholarly journals A Comparative Study to Evaluate the Efficacy and Safety of Single Dose Intravenous Iron Carboxymaltose vs Multidose Iron Sucrose in Postpartum Cases of Severe Iron Deficiency Anemia

2015 ◽  
Vol 7 (1) ◽  
pp. 18-21
Author(s):  
Ruchika Garg ◽  
Renu Rajvanshi
Keyword(s):  
Adverse Reaction ◽  
Single Dose ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Intravenous Iron ◽  
Iron Sucrose ◽  
Deficiency Anemia ◽  
Efficacy And Safety ◽  
Group A ◽  
Group B

ABSTRACT Objective To evaluate the efficacy and safety of single dose intravenous iron carboxymaltose vs multidose iron sucrose in postpartum cases of severe iron deficiency anemia. Materials and methods One hundred cases with iron deficiency anemia in postpartum patient were selected from postpartum wards and assigned in two groups of 50 each. In group A, iron carboxymaltose injection administered by intravenous infusion upto a maximum single dose of 20 ml of iron carboxymaltose injection (1000 mg of iron). In group B Iron sucrose was given as 200 mg elemental iron (2 ampules of 5 ml) in 100 ml of 0.9% normal saline infusion over 15 minute alternate days up to 5 days. All the patients were monitored for rise in hemoglobin level at 2, 4, 8 and 12 weeks of iron therapy, adverse effect and rise in hematological parameter at 4 weeks. Results In group A, mean Hb level rise is 3.95 g/dl and in group B, it is 3.32 g/dl at 4 weeks of initial therapy. In group A, 100% cases achieved target Hb at 12 weeks after therapy while in group B 98% cases achieved target Hb at 12 weeks after therapy. In group A, 12% cases have grade 1 adverse reaction while in group B, 20% cases have adverse reaction. Conclusion Administration of intravenous iron has a good clinical result, with minimum adverse reactions. Thus, we can conclude that intravenous iron carboxymaltose therapy is safe, convenient, more effective and faster acting than intravenous iron sucrose for treatment of severe iron deficiency anemia in postpartum patient. How to cite this article Garg R, Singh S, Singh S, Rajvanshi R. A Comparative Study to Evaluate the Efficacy and Safety of Single Dose Intravenous Iron Carboxymaltose vs Multidose Iron Sucrose in Postpartum Cases of Severe Iron Deficiency Anemia. J South Asian Feder Obst Gynae 2015;7(1):18-21.

scholarly journals Effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in pregnancy

2018 ◽  
Vol 7 (5) ◽  
pp. 1908
Author(s):  
Devdatt Laxman Pitale
Keyword(s):  
Side Effects ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Age Group ◽  
Oral Iron Therapy ◽  
The Mean ◽  
Anaemia In Pregnancy ◽  
In Pregnancy

Background: Anaemia in pregnancy is very common throughout our country impacting both mother and the newborn. The most common cause of anaemia in pregnancy is iron deficiency. The increased prevalence of iron deficiency anaemia amongst the pregnant women, especially in developing countries is a major cause of significant maternal morbidity and mortality. Intolerance to oral iron, inadequate absorption, and side effects leading to poor compliance are the major shortcomings in oral iron therapy. These factors are significant especially in anaemia near term. To overcome all these limiting factors associated with oral iron therapy, parenteral iron therapy is preferred. Aim of this study was to study effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in pregnancy.Methods: This prospective study was taken up to compare the effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in 30 antenatal women attending antenatal outpatient Department of Obstetrics and Gynaecology belonging to gestational age group of 28-34 weeks with anaemia in pregnancy.Results: Majority of pregnant women belonged to age group of 22-25 years.67% were primigravidas. The period of gestation varied from 28-34 weeks. In this study, the mean baseline haemoglobin was 8.4 g/dl before start of treatment and after iv iron sucrose treatment haemoglobin showed a mean value of 10.8g/dl. The mean baseline MCV was 70 fl/cell. Post treatment MCV after 4 weeks showed a significant mean rise of 12 fl/cell in the present study with no major side effects.Conclusions: Intravenous iron sucrose is highly effective over oral iron therapy for anaemia in pregnancy. It enables rapid correction of anaemia with minimal side effects.

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