scholarly journals β-hCG levels in second trimester as a predictor of gestational hypertension and preeclampsia

2022 ◽  
Author(s):  
Neha Rathore ◽  
Reema Khajuria ◽  
Rohini Jaggi
Keyword(s):  
Gestational Hypertension ◽  
Elevated Serum ◽  
High Serum ◽  
Second Trimester ◽  
Trimester Pregnancy ◽  
Beta Hcg ◽  
Increased Risk ◽  
Second Trimester Pregnancy ◽  
Β Hcg ◽  
A Prospective Study

Background: Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and remain amongst the most significant and intriguing unsolved problems in obstetrics. The goal of this study is to test the hypothesis that women with high serum β-hCG levels in early pregnancy are at higher risk of developing gestational hypertension and preeclampsia.Methods: This is a prospective study done in 200 women between 13 and 20 weeks of gestation, selected randomly for this study. Serum β-hCG estimation was done by Sandwich chemiluminescence immunoassay method and calculated in multiple of median (MOM).  They were followed till delivery for development of gestational hypertension and preeclampsia. Results were analysed statistically.Results: Out of 200 cases, 43 (21.5%) cases developed PIH. β-hCG levels were considered raised if the levels were >2 MOM.  Out of 39 cases with beta HCG levels >2 MOM, 32 (82.1%) developed PIH whereas 7 (17.9%) remain normotensives against. Also, higher levels of beta HCG are associated with increased severity of PIH (p<0.000). The sensitivity was 82%, specificity was 93.2% and positive predictive value was 74.3%.Conclusions: The study conclude that elevated serum β-hCG levels in women with second trimester pregnancy indicates increased risk of gestational hypertension and preeclampsia and raised β-hCG levels are associated with severity of disease

scholarly journals Serum beta hCG in early second trimester as a predictor of gestational hypertension

2018 ◽  
Vol 7 (6) ◽  
pp. 2355
Author(s):  
Aparna Rajesh ◽  
Vandana Muralidharan
Keyword(s):  
Gestational Hypertension ◽  
Screening Tests ◽  
Perinatal Morbidity ◽  
Singleton Pregnancy ◽  
Beta Hcg ◽  
Medical Academy ◽  
Increased Risk ◽  
Β Hcg ◽  
A Prospective Study

Background: Hypertensive disorders of pregnancy complicate upto 10% of pregnancies worldwide, and constitute one of the greatest causes of maternal and perinatal morbidity and mortality. The goal of this study is to evaluate the serum beta hCG levels in pregnant women as a predictor of gestational hypertension.Methods: This is a prospective study done at K. S. Hegde Medical Academy during the month of November 2015 to January 2017. Serum beta hCG was estimated between 14-20 weeks of gestation in 90 women with singleton pregnancy irrespective of parity. Regular follow up of the cases were done till delivery. Results were analysed statistically.Results: Out of 90 women, 81 women were followed till term and 12 (14.8%) cases developed gestational hypertension. β HCG levels (Mean±SD) were higher (69808.66±54764.7 vs. 38126.49±97419.2; p<0.28) in subjects who developed gestational hypertension. Serum beta hCG (median >32726 mIU/ml) has a sensitivity of 75%, specificity of 72.5% and accuracy of 72.8%.Conclusions: Our study indicate an increased risk of gestational hypertension in women with elevated levels of serum beta hCG. As yet there are no practically acceptable and reliable screening tests for gestational hypertension, serum beta hCG seems to be good noninvasive early predictor for the development of gestational hypertension.

scholarly journals Misoprostol for Termination of Second Trimester Pregnancy

2015 ◽  
Vol 1 (1) ◽  
pp. 16-19
Author(s):  
Sarada Duwal Shrestha ◽  
Alka Singh ◽  
Laxmi RC ◽  
Benita Pradhan ◽  
Wufei Shah ◽  
...  
Keyword(s):  
Side Effects ◽  
Success Rate ◽  
Congenital Anomalies ◽  
Second Trimester ◽  
Plain Language ◽  
Fetal Demise ◽  
Trimester Pregnancy ◽  
Second Trimester Pregnancy ◽  
Vaginal Misoprostol ◽  
Maternal Side

Introductions: The termination of second trimester pregnancy is challenging due unfavorable cervix. This study evaluate the efficacy and maternal side effects of intravaginal misoprostol for termination of second trimester pregnancy. Methods: During one year period from 15th June 2011 to 14th June 2012, Department of Obstetrics and Gynaecology of Patan Hospital, women admitted for second trimester termination of pregnancy for fetal congenital anomalies and intrauterine fetal demise were studied using the International Federation of Gynaecology and Obstetrics recommended doses of vaginal misoprostol. For congenital anomalies, 400 mcg 3 hourly to a maximum of 5 doses were used. For fetal demise, gestational age of 13-17 weeks received 200 mcg every 6 hourly to a maximum of 4 doses, and 18-26 weeks dose was adjusted to 100 mcg. Main outcome measures included success rate of abortion within 48 hours, induction to delivery interval and maternal side effects. Results: There were 40 patients during study period. Success rate for termination of 2nd trimester pregnancy within 48 hours was 88.8% for congenital anomalies. For fetal demise, success of termination was 90.9% at 13-17 weeks and 100% at 18-26 weeks. Median time from induction to delivery was 26.8 hours for congenital anomalies. For fetal demise, it was 18 hours for 13-17 weeks was and 24 hours at 18 to 26 weeks respectively. Abdominal pain was seen in all doses of misoprostol. Conclusions: Vaginal misoprostol is an effective method for termination of second trimester pregnancy. Plain Language Summary: The study was conducted to see the effectiveness of vaginal misoprostol for termination of second trimester pregnancy. The success rate of termination for congenital abnormality and fetal demise was high. Vaginal misoprostol was an effective method for termination of second trimester pregnancy. DOI: http://dx.doi.org/10.3126/jpahs.v1i1.13010 Journal of Patan Academy of Health Sciences. 2014 Jun;1(1):16-19

Complex Enterotubal Fistula and Abdominal-Pelvic Abscess Complicating Second Trimester Pregnancy Termination

1994 ◽  
Vol 10 (4) ◽  
pp. 263-269
Author(s):  
JOEL SOROSKY ◽  
ROBERT SQUATRITO ◽  
JOSEPH CONNOR ◽  
CHARLES DE PROSSE ◽  
JO ANN BENDA
Keyword(s):  
Pregnancy Termination ◽  
Pelvic Abscess ◽  
Second Trimester ◽  
Trimester Pregnancy ◽  
Second Trimester Pregnancy
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