scholarly journals Serum beta hCG in early second trimester as a predictor of gestational hypertension

2018 ◽  
Vol 7 (6) ◽  
pp. 2355
Author(s):  
Aparna Rajesh ◽  
Vandana Muralidharan
Keyword(s):  
Gestational Hypertension ◽  
Screening Tests ◽  
Perinatal Morbidity ◽  
Singleton Pregnancy ◽  
Beta Hcg ◽  
Medical Academy ◽  
Increased Risk ◽  
Β Hcg ◽  
A Prospective Study

Background: Hypertensive disorders of pregnancy complicate upto 10% of pregnancies worldwide, and constitute one of the greatest causes of maternal and perinatal morbidity and mortality. The goal of this study is to evaluate the serum beta hCG levels in pregnant women as a predictor of gestational hypertension.Methods: This is a prospective study done at K. S. Hegde Medical Academy during the month of November 2015 to January 2017. Serum beta hCG was estimated between 14-20 weeks of gestation in 90 women with singleton pregnancy irrespective of parity. Regular follow up of the cases were done till delivery. Results were analysed statistically.Results: Out of 90 women, 81 women were followed till term and 12 (14.8%) cases developed gestational hypertension. β HCG levels (Mean±SD) were higher (69808.66±54764.7 vs. 38126.49±97419.2; p<0.28) in subjects who developed gestational hypertension. Serum beta hCG (median >32726 mIU/ml) has a sensitivity of 75%, specificity of 72.5% and accuracy of 72.8%.Conclusions: Our study indicate an increased risk of gestational hypertension in women with elevated levels of serum beta hCG. As yet there are no practically acceptable and reliable screening tests for gestational hypertension, serum beta hCG seems to be good noninvasive early predictor for the development of gestational hypertension.

scholarly journals β-hCG levels in second trimester as a predictor of gestational hypertension and preeclampsia

2022 ◽  
Author(s):  
Neha Rathore ◽  
Reema Khajuria ◽  
Rohini Jaggi
Keyword(s):  
Gestational Hypertension ◽  
Elevated Serum ◽  
High Serum ◽  
Second Trimester ◽  
Trimester Pregnancy ◽  
Beta Hcg ◽  
Increased Risk ◽  
Second Trimester Pregnancy ◽  
Β Hcg ◽  
A Prospective Study

Background: Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and remain amongst the most significant and intriguing unsolved problems in obstetrics. The goal of this study is to test the hypothesis that women with high serum β-hCG levels in early pregnancy are at higher risk of developing gestational hypertension and preeclampsia.Methods: This is a prospective study done in 200 women between 13 and 20 weeks of gestation, selected randomly for this study. Serum β-hCG estimation was done by Sandwich chemiluminescence immunoassay method and calculated in multiple of median (MOM).  They were followed till delivery for development of gestational hypertension and preeclampsia. Results were analysed statistically.Results: Out of 200 cases, 43 (21.5%) cases developed PIH. β-hCG levels were considered raised if the levels were >2 MOM.  Out of 39 cases with beta HCG levels >2 MOM, 32 (82.1%) developed PIH whereas 7 (17.9%) remain normotensives against. Also, higher levels of beta HCG are associated with increased severity of PIH (p<0.000). The sensitivity was 82%, specificity was 93.2% and positive predictive value was 74.3%.Conclusions: The study conclude that elevated serum β-hCG levels in women with second trimester pregnancy indicates increased risk of gestational hypertension and preeclampsia and raised β-hCG levels are associated with severity of disease

Long-Term Clinical Results following Correction of Incompetent Superficial and Perforating Veins in Patients with Deep Venous Incompetence and Ulcers

1993 ◽  
Vol 8 (3) ◽  
pp. 128-131 ◽  
Author(s):  
H. Åkesson
Keyword(s):  
Venous Pressure ◽  
Clinical Results ◽  
Venous Ulceration ◽  
Perforating Veins ◽  
Venous Ulcers ◽  
Increased Risk ◽  
A Prospective Study ◽  
Volumetric Measures

Objectives: To assess the presence of venous ulcers following stripping of the saphenous vein and ligation of perforating veins in patients with deep venous incompetence. Design: Retrospective follow-up after a median of 41 months following surgery. Patients: Thirty operated limbs in 25 patients with venous ulcers, originally entering a prospective study of physiological changes following surgery for venous insufficiency. Interventions: An interview regarding absence of ulcers, expressed as a percentage of the follow-up time after surgery – the ‘ulcer-free period’. Correlation with ambulatory venous pressure (AVP) and foot volumetric measures following surgery. Main outcome measures: The presence or absence of venous ulcers. Results: The ulcer-free period for the whole group was 76%. There was a significant (p<0.05) difference in the ulcer-free period in limbs with an AVP below 60 mmHg (89%) compared with limbs with a higher AVP (70%). Conclusion: Failure to normalize AVP with surgery results in persistent high venous pressure and an increased risk of venous ulceration recurrences.

scholarly journals Mortality among persons experiencing musculoskeletal pain: a prospective study among Danish men and women

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Teresa Holmberg ◽  
Michael Davidsen ◽  
Lau Caspar Thygesen ◽  
Mikala Josefine Krøll ◽  
Janne Schurmann Tolstrup
Keyword(s):  
Pain Intensity ◽  
Cox Regression ◽  
Widespread Pain ◽  
Men And Women ◽  
Respiratory Mortality ◽  
Discriminatory Accuracy ◽  
Increased Risk ◽  
A Prospective Study ◽  
Risk Of Cancer

Abstract Background Musculoskeletal (MSK) pain affects many people worldwide and has a great impact on general health and quality of life. However, the relationship between MSK pain and mortality is not clear. This study aimed to investigate all-cause and cause-specific mortality in relation to self-reported MSK pain within the last 14 days, including spread of pain and pain intensity. Methods This prospective cohort study included a representative cohort of 4806 men and women aged 16+ years, who participated in a Danish MSK survey 1990–1991. The survey comprised questions on MSK pain, including spread of pain and pain intensity. These data were linked with the Danish Register of Causes of Death to obtain information on cause of death. Mean follow-up was 19.1 years. Cox regression analyses were performed with adjustment for potential confounders. Results In the study population (mean age 44.5 years; 47.9% men), 41.0% had experienced MSK pain within the last 14 days and 1372 persons died during follow-up. For both sexes, increased all-cause mortality with higher spread and intensity of MSK pain was observed; a high risk was observed especially for men with strong pain (HR = 1.66; 95% CI:1.09–2.53) and women with widespread pain (HR = 1.49; 95% CI:1.16–1.92). MSK pain within last 14 days yielded c-statistics of 0.544 and 0.887 with age added. Moreover, persons with strong MSK pain had an increased cardiovascular mortality, persons with moderate pain and pain in two areas had an increased risk of cancer mortality, and persons with widespread pain had an increased risk of respiratory mortality. Conclusions Overall, persons experiencing MSK pain had a higher risk of mortality. The increased mortality was not accounted for by potential confounders. However, when evaluating these results, it is important to take the possibility of unmeasured confounders into account as we had no information on e.g. BMI etc. Significance The present study provides new insights into the long-term consequences of MSK pain. However, the discriminatory accuracy of MSK pain was low, which indicates that this information cannot stand alone when predicting mortality risk.

scholarly journals Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications

2021 ◽  
Vol 10 (22) ◽  
pp. 5253
Author(s):  
Cosmin Citu ◽  
Radu Neamtu ◽  
Virgiliu-Bogdan Sorop ◽  
Delia Ioana Horhat ◽  
Florin Gorun ◽  
...  
Keyword(s):  
Breast Milk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Gestational Hypertension ◽  
Close Contact ◽  
Outpatient Setting ◽  
Serum Samples ◽  
Increased Risk ◽  
A Prospective Study

We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection.

scholarly journals Perinatal and Maternal Outcomes in Two Groups of Normal and At the Risk of Borderline Oligohydramnios in Late Preterm Pregnancy

2020 ◽  
Vol 8 (1) ◽  
pp. 29-32
Author(s):  
Saddiqa Hassan ◽  
Sana Ali ◽  
Sajid Hussain Sherazi
Keyword(s):  
Perinatal Outcomes ◽  
Late Preterm ◽  
Maternal Outcomes ◽  
Singleton Pregnancy ◽  
Apgar Scores ◽  
Border Line ◽  
Increased Risk ◽  
Borderline Patients ◽  
Group 2

Background: Pregnancy outcomes of a borderline oligohydramnios versus normal relatively comes to be slightly increasing meconium‐stained fluid, low Apgar scores and hyper bilirubinemia on follow up as perinatal outcomes and increased risk of C section as maternal outcome. There is currently insufficient evidence to recommend additional perinatal and maternal testing based on a borderline oligohydramnios. Clinical determination is considered in evaluating meconium‐stained fluid, low Apgar scores and hyper bilirubinemia. Objective: The purpose of this study is to determine the adverse perinatal and maternal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios. Setting: A total of 38 patients were studied, 19 were with normal AFI and 19 patients were of borderline AFI. Patients with normal AFI were referred as Group 1 and the other as Group 2. This study was conducted at Niazi Medical and Dental College, Sargodha. Population: Pregnant women with normal AFI at term and borderline patients with late preterm pregnancy and borderline oligohydramnios. Methods: This descriptive study was conducted at Niazi Medical and Dental College, Sargodha. This study comprised of 38 patients with normal AFI and border line AFI. Data of 19 patients with normal AFI and 19 patients with border line AFI was collected. The Inclusion Criteria was 19 singleton pregnancies of 36+6 weeks, with AFI ≤ 8 cm and 19 singleton pregnancy 37+ weeks with upto 24 cm AFI. In both groups, Maternal and perinatal outcomes were assessed. The results of both groups were compared in the end. Conclusion: The results of this study indicated that borderline AFI was not a risk for adverse perinatal and maternal outcomes in uncomplicated, late preterm pregnancies.    Int. J. Appl. Sci. Biotechnol. Vol 8(1): 29-32

Low Socio-Economic Status is Associated with Increased Risk of Frequent Headache: A Prospective Study of 22718 Adults in Norway

Cephalalgia ◽  
2002 ◽  
Vol 22 (8) ◽  
pp. 672-679 ◽  
Author(s):  
K Hagen ◽  
L Vatten ◽  
LJ Stovner ◽  
J-A Zwart ◽  
S Krokstad ◽  
...  
Keyword(s):  
Prospective Study ◽  
Educational Level ◽  
Chronic Headache ◽  
Economic Status ◽  
Low Ses ◽  
Prevalence Studies ◽  
Socio Economic Status ◽  
Increased Risk ◽  
A Prospective Study

Prevalence studies exploring the relation between socio-economic status (SES) and headache have shown conflicting results. This is the first prospective study analysing the relation between SES and risk of headache. A total of 22 685 adults not likely to suffer from headache were classified by SES at baseline in 1984-1986, and responded to a headache questionnaire in a follow-up 11 years later (1995-1997). SES at baseline was defined by educational level, occupation, and income. The risk of frequent headache and chronic headache (> 6, and ≥ 15 days/month, respectively) at follow-up was estimated in relation to SES. When defining SES by educational level or type of occupation, low status was associated with increased risk of frequent and chronic headache at follow-up. The risk of frequent and chronic headache decreased with increasing individual income, but only among men. We conclude that individuals with low SES had higher risk of frequent and chronic headache than people with high SES.

Waist-to-Height Gain and Triiodothyronine Concentrations in a Cohort of Socially Vulnerable Short-Stature Women: A Four-Year Follow-Up Study

2016 ◽  
Vol 68 (4) ◽  
pp. 298-305 ◽  
Author(s):  
Telma M.M.T. Florêncio ◽  
Nassib B. Bueno ◽  
Revilane A.P. Britto ◽  
Fabiana C.A. Albuquerque ◽  
Isabela L.L. Lins ◽  
...  
Keyword(s):  
Short Stature ◽  
Significant Interaction ◽  
Perinatal Period ◽  
Analysis Of Covariance ◽  
Height Ratio ◽  
Increased Risk ◽  
Before And After ◽  
Waist To Height Ratio ◽  
A Prospective Study

Background: Short stature that results from undernourishment during perinatal period is associated with an increased risk of diabetes and cardiovascular diseases in adulthood, particularly in poor populations. The present study investigated changes on anthropometric and metabolic parameters of socially vulnerable women with short stature. Methods: A prospective study with 48 women (19-45 years) who were mothers of undernourished children was conducted. Twenty-five of them were short (height ≤150 cm), and 23 were not short, to serve as a control (height >159 cm). Biochemical, anthropometric and dietary intake data were collected, before and after 4 years of follow-up. A mixed within-between analysis of covariance was used to assess the interaction between ‘group' and ‘time'. Results: Waist-to-height ratio increased only in the short stature group, with significant interaction (+0.03 ± 0.03 in short group vs. +0.01 ± 0.03 in control; p for interaction = 0.04). The short stature group showed a significant decrease in the plasma triiodothyronine (T3) concentrations, without significant interaction (-0.16 ± 0.23 ng/ml in short group vs. -0.04 ± 0.29 ng/ml in control; p for interaction = 0.20). Conclusion: Women of short stature presented an increase in waist-to-height ratio, with a simultaneous decrease in total plasma T3. These alterations may lead them to increased risk of comorbidities.

scholarly journals Term Delivery of a Complete Molar Pregnancy with a Coexistent Normal Pregnancy

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Manisha Chhetry ◽  
Aruna Pokharel ◽  
Amar Nath Chaudhary
Keyword(s):  
Breech Presentation ◽  
Normal Pregnancy ◽  
Molar Pregnancy ◽  
Healthy Male ◽  
Singleton Pregnancy ◽  
Complete Mole ◽  
Beta Hcg ◽  
Term Delivery ◽  
Normal Placenta

Twin pregnancy with a complete mole and a coexistent normal fetus reaching term is a rare occurrence. We report a case of a 21-yrs G2P1L0 un-booked patient at 39 weeks who was referred for the same condition diagnosed incidentally on ultrasound scan which showed a singleton pregnancy in breech presentation with a normal placenta and a heterogeneous cystic lesion seen anteriorly, suggesting a coexistent molar pregnancy. Cesarean section was done, and a healthy male baby was delivered with a grossly normal placenta and a second placenta with grape like vesicles. Histopathology confirmed the diagnosis of complete mole and normal placenta. Postoperative period was uneventful, and the patient was kept on beta hcg follow-up to monitor progression to gestational trophoblastic neoplasia, but it normalized by 12 weeks.

scholarly journals Placental location and development of preeclampsia: a longitudinal study

2019 ◽  
Vol 8 (4) ◽  
pp. 1283
Author(s):  
Ananya Priyadarshini ◽  
Purnima Upreti ◽  
Ruchira Nautiyal ◽  
Mamta Goyal
Keyword(s):  
Longitudinal Study ◽  
Pregnant Women ◽  
Urban Areas ◽  
Simple Random Sampling ◽  
Antenatal Clinic ◽  
Singleton Pregnancy ◽  
Invasive Test ◽  
Level Ii ◽  
Increased Risk ◽  
A Prospective Study

Background: Preeclampsia is one of the leading causes of morbidity and mortality worldwide. A number of pregnant women suffer from it after 20 weeks of their pregnancy. The study was designed to know the association between location of placenta and the development of preeclampsia in pregnant women. the purpose of the study is to determine the incidence of lateral location of placenta and to study the relation between placental location and development of preeclampsia.Methods: A prospective study conducted on pregnant women who attended the antenatal clinic of SRHU Hospital over period of 12 months. The study was hospital based longitudinal study with a sample size of 100 cases presenting over a period of 12 months in Obstetrics and Gynecology Department. Simple Random Sampling was used for random selection of antenatal case at 18 to 24 weeks gestation with singleton pregnancy, after taking written consent and agreeing for follow-up till delivery.Results: Out of the total 100 cases taken for the study, there were 68 cases of lateral placenta and 32 cases of central placenta. Most of the cases belonged to middle class living in urban areas. The development of preeclampsia is mainly due to mineral deficiency and high systolic BP.Conclusions: In present study, 48.5% patients with lateral placenta and 46.9% with central placenta developed pre-eclampsia.  There was a significant association that was found between laterality of placenta and development of PIH. The laterally located placenta is associated with increased risk of developing preeclampsia. Therefore, looking for placental laterality at the time of a mandatory antenatal ultrasound scanning (level II) may serve as a non-invasive test to predict pre-eclampsia.

scholarly journals Utility of second trimester beta HCG levels in prediction of gestational hypertension: a prospective cohort study

2017 ◽  
Vol 6 (3) ◽  
pp. 1040
Author(s):  
Heena Chowdhary ◽  
Rabia Khurshid ◽  
Shameema Parveen ◽  
Shagufta Yousuf ◽  
Showkat Hussain Tali ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Predictive Value ◽  
Gestational Hypertension ◽  
Beta Hcg ◽  
Observational Cohort ◽  
Β Hcg ◽  
Sensitivity Specificity ◽  
High Beta

Background: Gestational hypertension is a significant threat both to maternal and fetal health. However, it is still a distant dream to predict accurately its occurrence in early pregnancy. Objective was to find out if β HCG levels determined between 13 to 20 weeks of gestation can be used as a predictor for gestational hypertension.Methods: This prospective observational cohort study was conducted from August 2014 to January 2016. Serum β HCG levels were determined at 13 to 20 weeks of gestation of 190 normotensive pregnant women attending the antenatal clinics. They were followed for the development of gestational hypertension till 40 weeks of gestation or delivery.Results: Out of the total 190 women, 25 (13.1%) developed gestation hypertension. Of those who developed gestational hypertension, 22 (88%) were having β HCG levels >2 MOM (p<0.001). Absolute β HCG levels (Mean±SD) were also significantly higher (54907±29509 V/S 41095±19103; p<0.001) in subjects who later developed gestational hypertension. Sensitivity, specificity, positive predictive value and the negative predictive value for β HCG at >2 MOM were 83.3, 96.9, 80.0 and 97.5 respectively (95% CI).Conclusions: Pregnant women with high Beta HCG levels in early pregnancy have significantly higher risk for development of gestational hypertension.

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