scholarly journals Effects of total parenteral nutrition on postnatal growth in very low birth weight and extremely low birth weight newborns

2020 ◽  
Vol 8 (2) ◽  
pp. 714
Author(s):  
Divya Ahuja ◽  
Pritosh Srivastava ◽  
Anshuman Srivastava
Keyword(s):  
Amino Acids ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Very Low Birth Weight ◽  
Postnatal Growth ◽  
Extremely Low Birth Weight ◽  
High Dose ◽  
Preterm Newborns

Background: Prematurity is the most important cause of mortality in Under-5 children responsible for one million deaths/ year. Premature babies are not able to store enough nutrients for their optimal survival; it is essential to provide them total parenteral nutrition. Intravenous lipid infusion in neonates is linked with high risk of sepsis and thrombocytopenia. PN with amino acids and glucose can be imparted to achieve nutritional goal. This trial was intended to assess the effects of various components of amino acid PN on postnatal growth in VLBW and ELBW newborns.Methods: A prospective observational study was conducted from January 2018 - May 2019 in NICU of TMMC and RC which included preterm newborns with birth weight of less than 1500gms who received aminoven infusion. Anthropometric measurements, incidence of hypo/hypercalcaemia, hypo/hyperglycaemia, direct hyperbilirubinemia, incidence of sepsis were evaluated.Results: Out of 22 patients, 12 neonates received high dose aminoven therapy whereas 10 neonates received low dose aminoven therapy. It was seen that rapid rate of increment of amino acids had adequate weight on discharge, 72.72% have adequate growth among the rapid group compared to 36.36% among slower group. No significant changes in calcium metabolism or glucose metabolism were seen in both the groups.Conclusions: In resource limited settings, parenteral nutrition with intravenous amino acids have a better effect on the weight of preterm newborns at discharge when high doses of amino acids infusion started early with rapid increment in the dose.

scholarly journals MODERN EXPERIENCE OF PARENTERAL NUTRITION WITH STANDARDIZED PREPARATIONS OF INDUSTRIAL PRODUCTION IN PEDIATRIC PRACTICE: LITERATURE REVIEW

2020 ◽  
Vol 10 (4(38)) ◽  
pp. 69-76
Author(s):  
T. Znamenska ◽  
O. Vorobiova ◽  
Y. Marushko
Keyword(s):  
Clinical Trials ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Preterm Infants ◽  
Industrial Production ◽  
Pediatric Patients ◽  
Very Low Birth Weight ◽  
Extremely Low Birth Weight ◽  
Short Period

Parenteral nutrition can save the lives of newborns and children who cannot receive adequate oral or enteral nutrition due to premature birth, functional immaturity, intestinal failure or inability to tolerate breastfeeding enterally due to congenital surgical pathology of the gastrointestinal tract, respiratory, cardiovascular and other. Pediatric patients, in particular infants with very low and extremely low birth weight, are particularly vulnerable to energy deficiency and protein restriction, which occurs immediately after birth and / or during periods of serious illness. The aim ofthis work. Evaluate the current experience of using standardized drugs for parenteral nutrition in pharmacy and industrial production based on the analysis of the results of international clinical trials and published reviews in this regard. Materials and methods. The results of 27 scientific publications were retrospectively analyzed with clear results of clinical randomized observations (case-control studies, prospective cohort studies, time series and retrospective data), multicenter studies, meta-analyzes and systematic reviews of the use of standardized drugs nutrition, industrial production: Numeta G13E, Numeta G16E of the company "Baxter" (USA), etc., also 1 systematic review of the management of "ready-to-use" drugs for parenteral nutrition in newborns. A review of data from scientometric Internet databases: Pub Med, UpToDate, Medscape EU, Medscape Pediatrics, etc. Results. According to the literature, parenteral nutrition (PN) can be provided in the form of a standard mixture, currently mainly industrial production, which is designed to cover the nutritional needs of most patients of the same age group (pediatric, including neonatal) with a similar condition. Conclusions. Standard solutions for PN can be safely used in most pediatric and neonatal patients, including preterm infants with very low birth weight, usually for the short period of time (up to 2-3 weeks) required by most children. In general, standardized parenteral nutrition should be preferred to individualized solutions in most pediatric patients and infants, including preterm infants with very low birth weight. The ready-to-use standardized industrial product has the potential to reduce the risk of infection, provide a sufficient supply of nutrients, ensure the child's growth within the expected range, is easy to use, reduces prescription errors and potentially reduces economic costs. The short- and long-term impact of its use in subsequent clinical trials should be evaluated.

Effect of Total Parenteral Nutrition on Lipase Activity in the Stomach of Very Low Birth Weight Infants

Neonatology ◽  
1988 ◽  
Vol 53 (5) ◽  
pp. 261-266 ◽  
Author(s):  
Nitin R. Mehta ◽  
Teresa H. Liao ◽  
Margit Hamosh ◽  
Yolande F. Smith ◽  
Paul Hamosh
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Lipase Activity ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants

Urinary Oxalate Excretion by Very Low Birth Weight Infants Receiving Parenteral Nutrition

PEDIATRICS ◽  
1989 ◽  
Vol 84 (5) ◽  
pp. 860-863
Author(s):  
Thomas Campfield ◽  
Gregory Braden
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Very Low Birth Weight ◽  
Urinary Oxalate ◽  
Creatinine Ratio ◽  
Vlbw Infants ◽  
Oxalate Concentration ◽  
Oxalate Excretion

Renal calcifications have been described in very low birth weight (VLBW) infants, and diuretic drugassociated hypercalciuria is believed to play a role in the pathogenesis of this lesion. Hyperoxaluria is an improtant cause of renal stone formation in children and adults. Because parenteral nutrition solutions contain the oxalate precursors ascorbate and glycine, the relationship between total parenteral nutrition administration and oxalate excretion in VLBW infants was examined. Administration of approximately 0.5 g of total parenteral nutrition protein per kilogram per day to VLBW infants was associated with an increased urinary oxalate concentration and an increased urinary oxalate to creatinine ratio, when compared with VLBW infants receiving a glucose and electrolyte solution. A further increase in urinary oxalate concentration and oxalate to creatinine ratio was noted when total parenteral nutrition protein was increased to approximately 1.5 g of protein per kilogram per day. In VLBW infants who receive total parenteral nutrition, elevated urinary oxalate concentrations may develop and may be a factor in the pathogenesis of nephrocalcinosis in these infants.

Sign in / Sign up

Export Citation Format

Share Document