scholarly journals Lyell’s syndrome: a rare case report

2019 ◽  
Vol 6 (4) ◽  
pp. 1411
Author(s):  
Surya Rao Rao Venkata Mahipathy ◽  
Alagar Raja Durairaj ◽  
Narayanamurthy Sundaramurthy ◽  
Manimaran Ramachandran ◽  
Praveen Ganesh Natarajan
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Total Body Surface Area ◽  
Mucosal Damage ◽  
Electrolyte Balance ◽  
Rare Case Report ◽  
Lyell’S Syndrome ◽  
Total Body ◽  
Treatment Of Infection ◽  
Extensive Burns ◽  
Lyell's Syndrome

Lyell's syndrome or toxic epidermal necrolysis (TEN) is an epidermal detachment of more than 30% of total body surface area, most commonly due an idiosyncratic immune-allergic reaction to a drug. It causes an acute necrosis of the epidermis, with a clinical picture resembling extensive burns. There is also associated mucosal damage and can occasionally develop into a multiorgan having a poor prognosis. Here we report a case of toxic epidermal necrolysis, due to allopurinol intake and its management as in a large burns and stressing the importance of early treatment in an intensive care unit, with high vigil on fluid and electrolyte balance, prevention and treatment of infection with appropriate antibiotics and regular dressings.

Vajra Bhasma, Ayurvedic medicine: a rare and unusual cause of Lyell’s syndrome and its successful management

2020 ◽  
Vol 13 (10) ◽  
pp. e237891
Author(s):  
Shivakumar M Channabasappa ◽  
Bhavna Gupta ◽  
Shruthi Dharmappa
Keyword(s):  
Unusual Case ◽  
Total Body Surface Area ◽  
Bullous Lesion ◽  
Adequate Hydration ◽  
Life Threatening ◽  
Lyell Syndrome ◽  
Lyell’S Syndrome ◽  
Total Body ◽  
Lyell's Syndrome

Toxic epidermolysis necrosis (TEN) or Lyell syndrome is a potentially life-threatening immunological adverse skin disease, which mostly occurs secondary to the intake of an offending drug. It commonly manifests as a widespread exfoliating bullous lesion in skin and mucous membrane mimicking superficial burns and may result in hypovolemic and/or septic shock. Authors report an unusual case of Lyell’s syndrome in a 42-year-old woman, secondary to the intake of Ayurveda medicine ‘Vajra Bhasma’ (Diamond Ash) prescribed by an Ayurveda physician for treatment of her trigeminal neuralgia. After 8th day of continuous medication intake, she had prodromal illness and rapidly developing exfoliative skin lesion extended over 80% of total body surface area, breathing difficulty, dizziness and anuria. The case was successfully managed by timely diagnosis, adequate hydration and administration of immunoglobulins. After 17 days, the skin epithelium regenerated, and she improved clinically with some depigmented lesions at discharge, which were normalised without any sequel during her further follow-up visits in hospital. Identification and withdrawal of the suspected drug, adequate resuscitation and early immunoglobulin administration are critical in management of TEN.

Drug-induced toxic epidermal necrolysis (Lyell's syndrome) in a 4-year-old girl

1985 ◽  
Vol 144 (1) ◽  
pp. 91-93 ◽  
Author(s):  
Chr. Luderschmidt ◽  
O. Linderkamp ◽  
J. Ring
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Induced ◽  
Lyell’S Syndrome ◽  
Lyell's Syndrome

Toxic epidermal necrolysis (TEN) Lyell's syndrome

2005 ◽  
Vol 16 (5-6) ◽  
pp. 278-286 ◽  
Author(s):  
Virendra N. Sehgal ◽  
Govind Srivastava
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Lyell’S Syndrome ◽  
Lyell's Syndrome

scholarly journals TOXIC EPIDERMAL NECROLYSIS (LYELL’S SYNDROME)

2017 ◽  
Vol 9 (4) ◽  
pp. 144-152
Author(s):  
E. N. Kudelka ◽  
D. M. Shakhmanov ◽  
A. F. Sobolev ◽  
R. A. Ravodin ◽  
A. V. Chaplygin ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Lyell’S Syndrome ◽  
Lyell's Syndrome
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