scholarly journals Does full enteral feed from day one of life influence weight gain in hemodynamically stable VLBW babies weighing between 1000-1500 grams as against standard feeding? a randomized controlled trial

2020 ◽  
Vol 7 (4) ◽  
pp. 932
Author(s):  
Ramya S. Shanmugam ◽  
Mangala Bharathi ◽  
Kumutha Jayaraman
Keyword(s):  
Birth Weight ◽  
Human Milk ◽  
Enteral Feeding ◽  
Controlled Trial ◽  
Intravenous Fluid ◽  
Preterm Neonates ◽  
Intravenous Fluids ◽  
Randomized Controlled ◽  
Feeding Group ◽  
Full Enteral Feeding

Background: Preterm neonates post-natal growth should be similar to the intrauterine growth of the fetus of the same gestational age. This study aims to  evaluate the effects of full enteral feed (60 ml/kg/day of human milk on day one, 20ml/kg/day during feeding advancement) started from day one of life (intervention) in enhancing   the regain of birth weight compared to that of standard feed (both human milk feeds and intravenous fluid) in a group.Methods: Babies were started on enteral feeds with human milk at the rate of 60ml/kg/day from day one and progressed by increments of 20 ml/kg/day up to maximum enteral feed of 180 ml/kg/day. The primary outcomes like Number of days taken to regain the birth weight, Duration of hospital stay, Incidence of Necrotising Enterocolitis (NEC), Incidence of sepsis, need for intravenous fluid therapy was assessed and statically analysed.Results: Full enteral feeding group infants had lesser days of intravenous fluids. Full enteral feeding group regained birth weight at a mean age of 17.37±4.9 days and in the standard feeding group, birth weight was regained at a mean age of 19.8±4.3. Full enteral feeding group regained birth weight at a mean age of 13.12±2.17 days and in standard feeding group at a mean age of 15.38±3.57and this was statistically significant (p - 0.009). Full enteral feeding group babies had lesser number of days of intravenous fluids compared to babies in standard feeding group. It was statistically significant (p - 0.003).Conclusions: There is lack of awareness regarding dog bite and its management among the rural population.

scholarly journals Comparison of Sequential feeding and Continuous feeding on Blood Glucose of critically ill patients: A non-inferiority Randomized Controlled Trial

2019 ◽  
Author(s):  
Changjie Ren ◽  
Bo Yao ◽  
Miao Tuo ◽  
Hui Lin ◽  
Xiangyu Wan ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Critically Ill ◽  
Enteral Feeding ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Feeding Intolerance ◽  
Randomized Controlled ◽  
Feeding Group ◽  
Significant Difference ◽  
Continuous Feeding

Abstract Objective: The goal of this study is to compare sequential feeding and continuous feeding on blood glucose of critically ill patients. Methods: A non-inferiority randomized controlled trail was adopted in this study. A total of 62 patients were finally enrolled, who were fed with enteral nutritional suspension through gastric tubes. After achieving 80% of the nutrition target calories (25kcal/kg/d) through continuous feeding, the patients were then randomly assigned into sequential feeding and continuous feeding group. In sequential feeding group, the feeding/fasting time was reasonably determined, according to the circadian rhythm of the human body in traditional Chinese medicine theory. The total daily dosage of enteral nutritional suspension was equally distributed to the three time periods of 7-9 o 'clock, 11-13 o 'clock and 17-19 o 'clock. Enteral nutritional suspension in each time period was pumped at a uniform rate within two hours by enteral feeding pump. While in continuous feeding group, patients received continuous feeding with constant velocity by enteral feeding pump during the study. Blood glucose values at 5 points (6:00/11:00/15:00/21:00/1:00) were monitored and recorded in 7 consecutive days after randomization. Meanwhile, enteral feeding intolerance was also recorded. Results: No significant demographic or physiologic differences between the sequential feeding and continuous feeding group (P >0.05). The average of glucose in sequential feeding was no inferior to continuous feeding [8.8(7.3-10.3) mmol/L vs. 10.7(9.1-12.1) mmol/L, P for non-inferiority =0.038). Hyperglycemia in CF group was more often than SF group (36.1% vs. 23.0%, P＜0.01). There was no significant differences in glucose standard deviations and Glucosemax -Glucosemin between two groups (P＞0.05). But the coefficient of glucose variation in sequential feeding group was higher than continuous feeding group [24.5(22.2-27.6) % vs. 18.9(13.7-25.3) %, P=0.013). Moreover, no significant difference in the incidence of feeding intolerance during the 7 days were found (P> 0.05). Conclusions: In this non-inferiority study, average blood glucose value of critically ill patients with sequential feeding was not higher than continuous feeding. And the feeding intolerance in sequential feeding was similar to continuous feeding.

Efficacy of probiotics to prevent necrotizing enterocolitis in low birth weight preterm neonates.

2021 ◽  
Vol 28 (03) ◽  
pp. 328-332
Author(s):  
Shagufta Niazi ◽  
Farrukh Saeed ◽  
Shahla Tariq ◽  
Muhammad Azhar Farooq ◽  
Sanaullah Khan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Controlled Trial ◽  
Study Groups ◽  
Preterm Neonates ◽  
Randomized Controlled ◽  
Group A ◽  
Group B ◽  
Trial Setting

Objective: To compare the efficacy of probiotics in prevention of necrotizing enterocolitis (NEC) among low birth weight (LBW) preterm neonates. Study Design: Randomized controlled trial. Setting: Department of Pediatric Medicine, Unit-II, Services Hospital, Lahore. Period: September 2019 to February 2020. Material and Methods: A total of 260 LBW preterm neonates were enrolled. All the neonates were allocated to 2 groups with equal number of cases (130 in each group). Group-A was given probiotics whereas placebo was administered in Group-B. All the cases were admitted and follow ups were made up until 7th day. Occurrence of NEC was recorded among both groups. Results: Out of a total of 260 LBW preterm neonates, 142 (54.6%) were male and118 (45.4%) female. Overall, mean age was noted to be 1.48+0.50 days. Table-I shows that there was no statistical difference among neonates of both study groups in terms of age, gestational age and birth weight (p>0.05). Five (3.8%) neonates in Group-A and 14 (10.8%) in Group-B were found to have NEC. Efficacy of treatment in Group-A was significantly higher in comparison to Group-B. Conclusion: Probiotics are effective in the prevention of NEC in preterm LBW neonates. Prophylactic usage of probiotics among preterm neonates is noted to be helpful in avoiding development of NEC.

scholarly journals Effect of targeted vs standard fortification of breast milk on growth and development of preterm infants (≤ 32 weeks): study protocol for a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Joanna Seliga-Siwecka ◽  
Anna Chmielewska ◽  
Katarzyna Jasińska
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Controlled Trial ◽  
Low Birth Weight Infants ◽  
Randomized Controlled ◽  
Link Type

Abstract Background Human milk is recommended for all very low birth weight infants. Breastmilk is highly variable in nutrient content, failing to meet the nutritional demands of this group. Fortification of human milk is recommended to prevent extrauterine growth retardation and associated poor neurodevelopmental outcome. However, standard fortification with fixed dose multicomponent fortifier does not account for the variability in milk composition. Targeted fortification is a promising alternative and needs further investigation. Methods This randomized controlled trial will recruit preterm infants (≤ 32 weeks of gestation) within the first 7 days of life. After reaching 80 ml/kg/day of enteral feeding, patients will be randomized to receive standard fortification (HMF, Nutricia) or targeted fortification (modular components: Bebilon Bialka, Nutricia—protein; Polycal, Nutricia—carbohydrates; Calogen, Nutricia—lipids). The intervention will continue until 37 weeks of post-conception age or hospital discharge. Parents and outcome assessors will be blinded to the intervention. The primary outcome measure is velocity of weight, length, and head growth until 36 weeks post-conceptional age or discharge. Secondary outcomes include neurodevelopment at 12 months assessed with Bayley Scale of Development III, repeated at 36 months; body composition at discharge and at 4 months; and incidence of necrotizing enterocolitis, sepsis, retinopathy of prematurity, and bronchopulmonary dysplasia. Discussion Targeted fortification has previously been shown as doable in the neonatal intensive care unit context. If it shows to improve growth and neonatal outcome, choosing the targeted fortification as a first line nutritional approach in very low birth weight infants may become a recommendation. Trial registration ClinicalTrials.govNCT03775785, Registered on July 2019.

Early versus Delayed Human Milk Fortification in Very Low Birth Weight Infants–A Randomized Controlled Trial

2016 ◽  
Vol 174 ◽  
pp. 126-131.e1 ◽  
Author(s):  
Sanket D. Shah ◽  
Narendra Dereddy ◽  
Tamekia L. Jones ◽  
Ramasubbareddy Dhanireddy ◽  
Ajay J. Talati
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Very Low Birth Weight ◽  
Controlled Trial ◽  
Low Birth Weight Infants ◽  
Randomized Controlled

Randomized Controlled Trial on Effect of Intermittent Early Versus Late Kangaroo Mother Care on Human Milk Feeding in Low-Birth-Weight Neonates

2017 ◽  
Vol 33 (3) ◽  
pp. 533-539 ◽  
Author(s):  
Dhaarani Jayaraman ◽  
Kanya Mukhopadhyay ◽  
Anil Kumar Bhalla ◽  
Lakhbir Kaur Dhaliwal
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Hospital Stay ◽  
Controlled Trial ◽  
Kangaroo Mother Care ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Milk Feeding

Background: Breastfeeding at discharge among sick low-birth-weight (LBW) infants is low despite counseling and intervention like kangaroo mother care (KMC). Research aim: The aim was to study the effects of early initiation of KMC on exclusive human milk feeding, growth, mortality, and morbidities in LBW neonates compared with late initiation of KMC during the hospital stay and postdischarge. Methods: A randomized controlled trial was conducted in level 2 and 3 areas of a tertiary care neonatal unit over 15 months. Inborn neonates weighing 1 to 1.8 kg and hemodynamically stable were randomized to receive either early KMC, initiated within the first 4 days of life, or late KMC (off respiratory support and intravenous fluids). Follow-up was until 1 month postdischarge. Outcomes were proportion of infants achieving exclusive human milk feeding and direct breastfeeding, growth, mortality and morbidities during hospital stay, and postdischarge feeding and KMC practices until 1 month. Results: The early KMC group ( n = 80) achieved significantly higher exclusive human milk feeding (86% vs. 45%, p < .001) and direct breastfeeding (49% vs. 30%, p = .021) in hospital and almost exclusive human milk feeding (73% vs. 36%, p < .001) until 1 month postdischarge than the late KMC group ( n = 80). The incidence of apnea (11.9% vs. 20%, p = .027) and recurrent apnea requiring ventilation (8.8% vs. 15%, p = .02) were significantly reduced in the early KMC group. There was no significant difference in mortality, morbidities, and growth during the hospital stay and postdischarge. Conclusion: Early KMC significantly increased exclusive human milk feeding and direct breastfeeding in LBW infants.

Sign in / Sign up

Export Citation Format

Share Document