scholarly journals Transitional cell carcinoma of the upper urinary tract: a puzzle

2020 ◽  
Vol 7 (10) ◽  
pp. 1585
Author(s):  
Soumish Sengupta ◽  
Supriya Basu ◽  
Kadambari Ghosh
Keyword(s):  
Urinary Tract ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Transitional Cell ◽  
Expectant Management ◽  
Upper Urinary Tract ◽  
Urinary Tuberculosis ◽  
Gross Haematuria

Transitional cell carcinoma (TCC) of the upper urinary tract has a puzzling presentation. This is a case report of a 44 year old male with history for smoking 20 pack years presenting with cough, haemoptysis and microscopic haematuria. His sputum was positive for acid fast bacilli. He was treated as pulmonary tuberculosis (PTB) but had gross haematuria a month after initiation of anti-tubercular drugs (ATD). He was investigated with computed tomography (CT) imaging and was found to have thickened renal pelvis and ureter. It was initially thought as a case of genito-urinary tuberculosis (GUTB). Expectant management for gross haematuria failed. The patient was stabilised and taken up for open nephroureterectomy under general anaesthesia (GA). Histopathological report suggested it to be high grade TCC of the left renal pelvis extending to upper ureter. He did well with completion of ATD. He was not started on adjuvant chemotherapy for fear of exacerbation of PTB. He is under regular and uneventful follow up in the outpatient department (OPD).  

Percutaneous Bcg Treatment in Superficial Transitional Cell Cancer of the Upper Urinary Tract

1993 ◽  
Vol 60 (1) ◽  
pp. 34-36 ◽  
Author(s):  
P. Bassi ◽  
A. Tasca ◽  
F. Zattoni ◽  
A. Calabrò ◽  
G. Abatangelo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Cancer ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Feasible Option ◽  
Transitional Cell Cancer ◽  
Disease Free

From January 1989 to September 1992, 5 patients (age 58–68 years) were treated with percutaneous Pasteur BCG for superficial transitional cell carcinoma of the upper urinary tract. In 4 cases BCG was prophylactic after endourological resection of the tumors. In one case of bilateral Tis of the upper urinary tract, BCG was administered for therapeutical purposes. Every patient received 375 mg Pasteur BCG in 250 ml saline, every 2 weeks for 6 consecutive weeks in 2 patients, 5 weeks in 1, and 4 in 2. No major complications were observed. After a median follow-up of 10.2 months, 4 patients are disease free, 1 patient underwent nephroureterectomy. Percutaneous BCG in upper tract superficial transitional cell cancer seems a feasible option in selected cases.

Long-term follow-up of endoscopically treated upper urinary tract transitional cell carcinoma

Urology ◽  
1996 ◽  
Vol 47 (6) ◽  
pp. 819-825 ◽  
Author(s):  
Daniel S. Elliott ◽  
Michael L. Blute ◽  
David E. Patterson ◽  
Erik J. Bergstralh ◽  
Joseph W. Segura
Keyword(s):  
Urinary Tract ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Long Term Follow Up

Upper tract transitional cell carcinoma following or related to bladder cancer: Controversies

1996 ◽  
Vol 63 (1) ◽  
pp. 25-28
Author(s):  
S. Cosciani Cunico ◽  
E. Frego ◽  
M. Scanzi ◽  
T. Zanotelli ◽  
E. Panizza ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Tract ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Vesicoureteral Reflux ◽  
Transitional Cell ◽  
Latency Period ◽  
Upper Urinary Tract

— The incidence of upper urinary tract transitional cell carcinoma (UTTCC) following a bladder cancer has been studied in 1731 urothelial tumours from 1984 to 1995. The UTTCC were 88: 59 primitive, 6 synchronous and 23 metachronous after a bladder cancer (1672). Of the 23 metachronous UTTCC, 17 followed TURBT (17/1310 = 1.3%): the latency period was very long (64.8 months); grading and staging were mostly similar to the foregoing bladder tumours. A vesicoureteral reflux raised the metachronous UTTCC rate to 17.6%. A neoplastic distal ureter was found during radical cystectomy in 2.24%. During the follow-up of 362 radical cystectomies 6 (1.65%) metachronous UTTCC were recorded. A metachronous UTTCC is always a poor prognostic sign. There are some controversies concerning this topic such as: the role of IVP and urine cytology in the follow-up of bladder cancer, the management of a vesicoureteral reflux in bladder cancer and the choice of a urinary diversion in the event of an upper urinary tract at high risk for UTTCC.

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