scholarly journals Booster dose against COVID-19- An important tool in the fight against the SARS-CoV-2

2021 ◽  
Vol 6 (4) ◽  
pp. 210-211
Author(s):  
Sankalp Yadav
Keyword(s):  
Booster Dose

scholarly journals A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

Med ◽  
2020 ◽  
Author(s):  
Alyssa Silva-Cayetano ◽  
William S. Foster ◽  
Silvia Innocentin ◽  
Sandra Belij-Rammerstorfer ◽  
Alexandra J. Spencer ◽  
...  
Keyword(s):  
Booster Dose ◽  
Vaccine Candidate ◽  
Aged Mice

scholarly journals Healthcare-associated Transmission of COVID-19 Among Thai Healthcare Personnel Who Receive 2 Doses of a COVID-19 Vaccine: A Call for Considering a Booster Dose

2021 ◽  
pp. 1-9
Author(s):  
Anucha Apisarnthanarak ◽  
Sira Nantapisal ◽  
Thanus Pienthong ◽  
Piyaporn Apisarnthanarak ◽  
David J. Weber
Keyword(s):  
Booster Dose ◽  
Healthcare Personnel ◽  
Healthcare Associated

Quality assurance of the EORTC trial 22881/10882: “assessment of the role of the booster dose in breast conserving therapy”: the Dummy Run

1991 ◽  
Vol 22 (4) ◽  
pp. 290-298 ◽  
Author(s):  
G. van Tienhoven ◽  
N.A.M. van Bree ◽  
B.J. Mijnheer ◽  
H. Bartelink
Keyword(s):  
Quality Assurance ◽  
Booster Dose ◽  
Breast Conserving Therapy

scholarly journals Successful Memory Response following a Booster Dose with a Virosome-Formulated Hepatitis A Vaccine Delayed Up to 11 Years

2011 ◽  
Vol 18 (5) ◽  
pp. 885-887 ◽  
Author(s):  
Christoph Hatz ◽  
Robert van der Ploeg ◽  
Bernhard R. Beck ◽  
Gert Frösner ◽  
Marjory Hunt ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Booster Dose ◽  
Immune Memory ◽  
Memory Response ◽  
Primary Dose ◽  
Full Protection

ABSTRACTBoosting adult travelers with the virosome-formulated, aluminum-free hepatitis A vaccine Epaxal up to 128 months after a single primary dose confers full protection against hepatitis A, even in travelers aged 50 years and above. Delaying the booster dose did not influence the immune memory response to Epaxal.

MULTIPLE ANTIGEN IMMUNIZATION OF INFANTS AGAINST POLIOMYELITIS, DIPHTHERIA, PERTUSSIS, AND TETANUS

PEDIATRICS ◽  
1962 ◽  
Vol 30 (5) ◽  
pp. 720-736
Author(s):  
Clarence D. Barrett ◽  
I. William McLean ◽  
Joseph G. Molner ◽  
Eugene A. Timm ◽  
Charles F. Weiss
Keyword(s):  
Booster Dose ◽  
Active Immunization ◽  
Maternal Antibody ◽  
Control Group ◽  
Tetanus Antitoxin ◽  
The Third ◽  
Multiple Antigen ◽  
Primary Series ◽  
Initial Injection ◽  
Pertussis Antigen

This study was designed to determine the earliest age in infancy at which immunization against poliomyelitis, diphtheria, tetanus, and pertussis can be started using a multiple antigen containing component antigens against all four diseases. Subjects ranged in age from 1 day old through 6 months old at time of initial injection. All were given a series of four injections of 0.5 ml of DPT-polio antigen 4 weeks apart followed by a fifth dose (0.5 ml) of the same material 6 months later. A control group received 0.5 ml of a DPT antigen at monthly intervals for their first four doses, but were given a DPT-polio injection (0.5 ml) for their fifth dose. Although it is evident that there is a progressive response in relation to age of the infant at time of initial inoculation, in respect to poliomyelitis and pertussis immunization, it was apparent that the capacity of the 3-month-old infant to respond to active immunization closely approximates that of the 6-month-old. Ninety per cent showed definite evidence of an immune response to all three poliovirus types despite extremely high levels of preprimary maternal antibody in the majority of 3-month-old infants under study. Pertussis antibody response, as measured by agglutinin titers, was as good in the 3-month-old as in the 6-month-old infants. The response in the 2-month-old infants was relatively poor at the postprimary stage but was equivalent to that of the older infants at the postbooster interval. There was no indication that response to pertussis immunization was impaired by the inclusion of pertussis antigen in the quadrivalent antigen under study. Diphtheria and tetanus antitoxin titers were excellent regardless of age at initial inoculation. The results indicate that four doses of DPT-polio combined antigen given at monthly intervals will overcome the interference of high levels of maternal antibody in respect to poliomyelitis immunization and that the primary series of injections may be started as early as the third month of life. It is important, however, that this primary series of inoculations be followed by a booster dose of the same antigen preparation in about 6 months in order to reinforce the basic immunity.

COMBINED IMMUNIZATION AGAINST DIPHTHERIA, TETANUS AND PERTUSSIS IN NEWBORN INFANTS

PEDIATRICS ◽  
1949 ◽  
Vol 3 (2) ◽  
pp. 181-194
Author(s):  
PAUL A. DI SANT'AGNESE
Keyword(s):  
Booster Dose ◽  
Newborn Infants ◽  
Active Immunization ◽  
Striking Difference ◽  
Tetanus Antitoxin ◽  
The Third ◽  
Number Of Patients ◽  
Diphtheria Antitoxin ◽  
Antibody Titers ◽  
One Year

Additional serologic studies are presented of a group of newborn infants whose antibody production following combined prophylactic inoculation against tetanus, diphtheria and pertussis was reported in a previous paper. Duration of Antibody Titers: In the 10 months following the last injection of triple combined antigen a steady decline in diphtheria antitoxin titers was observed which was more marked in patients who had achieved high antibody levels. A similar decrease was found in the percentage of infants with high titers of tetanus antitoxin, but there were no cases whose tetanus antitoxin level dropped to less than the "protective" titer (0.1 unit/cc.). Progressive decrease in diphtheria and tetanus antitoxin titers with passage of time is in agreement with findings of others. After the third and last immunizing injection, a rapid initial decrease was noted in the number of patients with "protective" pertussis agglutinin titers (1:400 or higher); then a levelling off took place and no further change was noted in the next six months. On the other hand, a steady decline was found in the percentage of infants with "high" agglutinin levels (1:3200). To our knowledge this has not been observed before. The young age of our patients at the time of the basic injections may have been responsible for the findings. Antibody Titers After Booster Dose: One group of infants was reinjected at the age of six months (four months after the third and last immunizing injection), another group at one year of age (10 months after the last injection). All booster doses consisted of 0.5 cc. of the same triple combined antigen used in basic immunization. After booster a marked increase was noted in diphtheria antitoxin titers to a level higher than that observed following the basic immunizing injections. Tetanus antitoxin response was considered to have been equally good, although more difficult to evaluate because of the high antitoxin levels present before reinjection. In the case of pertussis agglutinins, it appeared as if there were a "ceiling" of about 60% of infants who could, even after reinjection, develop a "protective" agglutinin titer (1:400 or higher). A striking difference was observed in both pertussis agglutinin levels and diphtheria antitoxin titers achieved by infants reinjected at six months and one year of age. This was thought to be due to immaturity of the immune mechanisms in the younger age group. An added factor in the case of diphtheria antitoxin in some patients may have been the persistence of passive antibodies acquired transplacentally. Antibody titers also were determined six months after booster dose in the infants who had been reinjected at the age of six months. A marked decrease was observed in the percentage of patients with "protective" pertussis agglutinin titers and "high" (1.0 unit/cc.) diphtheria antitoxin levels. No reduction was noted in tetanus antitoxin titers. Effects of Passive immunity to Diphtheria on Active immunization with Diphtheria Toxoid: With only one exception, all infants tested after a booster dose had been administered between 6 and 12 months of age had "protective" diphtheria antitoxin titers (0.03 units/cc. or more). Active immunization against diphtheria was therefore considered to have been achieved in all cases (with one exception) despite the passively transmitted antitoxin present at birth in over half the cases. While passive diphtheria antitoxin present at birth did not prevent "sensitization" of the antibody-forming tissues to the diphtheria antigen, it did decrease significantly the amounts of antitoxin actively produced in response to basic inoculation. Reasons for the success of active diphtheria immunization in this series are discussed. Arguments against active immunization of mothers in pregnancy for protection of their offspring are considered.

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