Modified biophysical profile in the role of predicting fetal outcome in high risk pregnancies

Background: The timely detection of morbid changes in the fetal status followed by adequate interventions to avoid death or disability is one of the most important objectives of prenatal care. Objective of present study was to Comparing the role of modified biophysical profile and the cerebroplacental ratio in fetal outcome in low risk and high risk pregnancies.Methods: Two hundred and seventy three singleton pregnant women were included in this study. Following routine examination, amniotic fluid index, pulsatility index of middle cerebral artery and pulsatility index of umbilical artery, uterine artery mean pulsatility index were evaluated. Non stress test (NST) was done. Modified biophysical profile (MBPP) and Cerebroplacental ratio (CPR in percentile) was generated. Caeserean section because of Fetal distress, birth weight <10th centile, 5min APGAR <7, NICU stay >24hours were used in evaluating the perinatal outcome.Results: Out of 273 cases, 107 cases had poor perinatal outcome. Out of 107 cases, 35.5% cases were IUGR, 39.2% cases underwent caesarean section in view of fetal distress, 39.2% babies had 5min APGAR <7 and 32.7% babies had stayed in NICU for >24hrs. In high risk cases, poor perinatal outcome was seen in 45.5% pregnancies and 36.7% in low risk pregnancies. Sixty seven percent of these cases had abnormal modified biophysical profile and only 7.4% cases had cerebroplacental ratio <1.Conclusions: Modified biophysical profile was proved to be more significant than cerebroplacental ratio in prediction of perinatal outcome.

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Vasoactive factors in the preeclampsia pathogenesis

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2006-12-1-22-31 ◽

2006 ◽

Vol 12 (1) ◽

pp. 22-31

Author(s):

V. .. Reznic

Keyword(s):

High Risk ◽

Fetal Outcome ◽

Severe Preeclampsia ◽

Clinical Marker ◽

Vasoactive Factors ◽

Underlying Causes ◽

Active Research ◽

Prospective Longitudinal ◽

Risk Of Preeclampsia

Preeclampsia-eclampsia is still one oi the leading causes of maternal and fetal morbidity and mortality. Despite active research for many years, the etiology of this disorder exclusive to human pregnancy is enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to the signs of hypertension, proteinuria and edema, findings that allow us to make ithe diagnosis of the «syndrome» of preeclampsia. Despite improved prenatal care, severe preeclampsia and eclampsia still occur. Although understanding of the pal pathophysiology of there disordes has improved, treatment has not changed significantly in over 30 years. Although postponement of delivery in selected women with severe preeclampsia improves fetal outcome to a degree, this is not done without risk to the mot her. The search for the underlying cause of this disorder and for a clinical marker to predict those women who will develop preeclampsia-eclampsia is ongoing, with its prevention the ultimate goal. Moreover, prospective longitudinal studies are needed to better assess the role of circulating angiogenic factors for the identification women at high risk of preeclampsia and the early diagnosis of disease.

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ROLE OF BIOPHYSICAL PROFILE IN HIGH RISK PREGNANCIES

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/403 ◽

2016 ◽

Vol 5 (32) ◽

pp. 1710-1712

Author(s):

Mahapara Manzoor ◽

Humera Noor ◽

Shazia Ashraf ◽

Shiveta Koul ◽

Asifa Ali

Keyword(s):

High Risk ◽

Biophysical Profile

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Role of Modified Biophysical Profile in High Risk Pregnancy in Predicting Fetal Outcome

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v18i3.2513 ◽

2020 ◽

Vol 18 (3) ◽

pp. 401-405

Author(s):

Santosh Jha ◽

Ganesh Dangal

Keyword(s):

High Risk ◽

Amniotic Fluid ◽

Neonatal Resuscitation ◽

Fetal Outcome ◽

High Risk Pregnancy ◽

Amniotic Fluid Index ◽

Cross Sectional ◽

Risk Pregnancy ◽

Increased Risk ◽

Biophysical Profile

Background: High risk pregnant women have increased risk of maternal and neonatal morbidity and mortality. Antepartum surveillance is important and should be effective in such conditions. Modified biophysical profile is the method of antepartum surveillance which comprises of cardiotocography and amniotic fluid index. Methods: A cross-sectional study was carried out in Paropakar Maternity and Women’s Hospital from February 2019 to January 2020 to determine the effectiveness of modified biophysical profile. Cardiotocography was interpreted as reactive, equivocal and non-reactive. AFI was considered normal if it was 5 to 24 cm. In the study 172 high risk cases at term and not in labor were included. Each case was subjected to cardiotocography then amniotic fluid index was obtained using real time sonography where it was measured from all four quadrants. Modified biophysical results were obtained and then were divided into 2 arms as normal modified biophysical profile and abnormal modified biophysical profile then analysis was done. Results: Of 172 cases, there were 97 (56.4%) cases in normal modified biophysical profile and remaining 75 (43.6%) in abnormal modified biophysical profile group. The rate of cesarean section increased when there was abnormal modified biophysical profile. Neonatal resuscitation and admission was increased in abnormal modified biophysical profile. Conclusions: Normal modified biophysical profile in high risk pregnancy had more cases of vaginal delivery and less adverse fetal outcome like low APGAR score, neonatal resuscitation and neonatal intensive care admission. Keywords: Amniotic fluid index; cardiotocography; fetal surveillance; modified biophysical profile

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The role of modified biophysical profile in predicting perinatal outcome in high risk pregnancies

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20182337 ◽

2018 ◽

Vol 7 (6) ◽

pp. 2287

Author(s):

Jankidevi S. Borade ◽

Sushma P. Sharma

Keyword(s):

High Risk ◽

Amniotic Fluid ◽

Perinatal Outcome ◽

Stress Test ◽

Neonatal Resuscitation ◽

Amniotic Fluid Index ◽

Biophysical Profile ◽

Fetal Surveillance ◽

The Impact

Background: The goal of antepartum fetal surveillance is early identification of the compromised fetus and timely intervention when the fetus is at risk, but still in an uncompromised state. Modified Biophysical Profile (MBPP) includes Amniotic Fluid Index (AFI) and non stress test (NST). AFI is a marker of long term placental function and NST is a marker of short term fetal condition. The aim of this study is to assess the role of Modified Biophysical Profile in high risk pregnancies and assess perinatal outcome and to study the impact of NST and AFI individually in high risk pregnancies.Methods: 100 ANC patients with high risk factors were evaluated with modified biophysical profile 37 week onwards with non stress test (NST) for 20 mins and amniotic fluid index (AFI) with 4 quadrant technique. High risk pregnancies include preeclampsia, IUGR, oligohydramnios, postdated pregnancy, etc. and various parameters were assessed to determine perinatal and maternal morbidity. All parameters were statistically analyzed.Results: The above study states that need for LSCS, intrapartum fetal distress, meconium stained liquor, APGAR score, need for neonatal resuscitation and perinatal morbidity were definitely higher in cases with abnormal MBPP.Conclusions: Thus MBPP is an easy, cost effective and time saving measure and hence can be used as a primary antepartum fetal surveillance test to predict perinatal outcome and provide timely intervention in high risk pregnancies.

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