P542 Prevalence and prognostic role of ABI (Ankle Brachial Index) in patients with high risk of cardiovascular events. The PATHOS (polyvascular atherothrombosis: an observational survey) study

2003 ◽  
Vol 24 (5) ◽  
pp. 88
Author(s):  
S URBINATI
Angiology ◽  
2020 ◽  
Vol 71 (9) ◽  
pp. 831-839
Author(s):  
Nuccia Morici ◽  
Valentina Molinari ◽  
Silvia Cantoni ◽  
Andrea Rubboli ◽  
Laura Antolini ◽  
...  

Individual parameters of complete blood count (CBC) have been associated with worse outcome in patients with acute coronary syndrome (ACS). However, the prognostic role of CBC taken as a whole has never been evaluated for long-term incidence of major adverse cardiovascular events (MACEs). Patients were grouped according to their hematopoietic cells’ inflammatory response at different time points during hospital stay. Patients with admission white blood cell count >10 × 109/L, discharge hemoglobin <120 g/L, and discharge platelet count >250 × 109/L were defined as “high-risk CBC.” Among 1076 patients with ACS discharged alive, 129 (12%) had a “high-risk CBC” and 947 (88%) had a “low-risk CBC.” Patients with “high-risk CBC” were older and had more comorbidities. Over a median follow-up of 665 days, they experienced a higher incidence of MACE compared to “low-risk CBC” patients (18.6% vs 8.1%). After adjustment for age, age-adjusted Charlson comorbidity index, female sex, cardiac arrest, suboptimal discharge therapy, coronary artery bypass, and ejection fraction, a high-risk CBC was significantly associated with increased MACE occurrence (adjusted hazard ratio 1.80; 95% CI: 1.09-3.00). The CBC was a prognostic marker in patients with ACS, and its evaluation at admission and discharge could better classify patient’s risk and improve therapeutic management.


2017 ◽  
Vol 15 (4) ◽  
pp. e661-e666 ◽  
Author(s):  
Gian Maria Busetto ◽  
Matteo Ferro ◽  
Francesco Del Giudice ◽  
Gabriele Antonini ◽  
Benjamin I. Chung ◽  
...  

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Paolo Gontero ◽  
Andrea Zitella ◽  
Kneitz Burkhard ◽  
Donatella Pacchioni ◽  
Simone Giona ◽  
...  

2019 ◽  
pp. 132-138 ◽  
Author(s):  
Shirin Bajaj ◽  
Zachary J. Wolner ◽  
Stephen W. Dusza ◽  
Ralph P. Braun ◽  
Ashfaq A. Marghoob ◽  
...  

Background/Objectives: Although total body skin examination (TBSE) is the primary screening mechanism for melanoma, there is no consensus on which anatomic sites a screening TBSE should include. We sought to establish which anatomic sites are examined during routine (>90%) TBSEs of patients at high risk for skin cancer. Methods: A Google survey was emailed to 173 international dermatologist skin cancer specialists. Results: More than 75% of participants reported routinely examining the scalp, ears, face and neck, trunk, breasts, inframammary areas, axillae, extremities, palms and soles, nails, interdigital spaces, and buttocks. The least frequently inspected anatomic sites included genitalia, with male genitalia more frequently examined than female (penis n = 39; 52%; labia majora n = 21; 28%; P = 0.003), the perianal region (n = 26; 34.7%), and the ocular conjunctiva and oral mucosa (n = 35; 46.7%). Participants cited not screening these areas because of perceived patient discomfort, low prevalence of malignancy, and the expectation that other specialists examine the area. Conclusions: The role of routine surveillance of neglected anatomic sites is unclear and warrants further discussion weighing potential mortality benefit against the incidence of melanoma in obscure sites, morbidity of intervention in sensitive sites, cost-effectiveness, and potential for patient discomfort.


2019 ◽  
Vol 58 (6) ◽  
pp. e511-e512
Author(s):  
George Galyfos ◽  
Georgios Sachsamanis ◽  
Ioannis Sachmpazidis ◽  
Christiana Anastasiadou ◽  
Georgios Kastrisios ◽  
...  

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 66-66
Author(s):  
Davide Bimbatti ◽  
Marco Maruzzo ◽  
Giuseppina Tierno ◽  
Eleonora Bergo ◽  
Francesco Pierantoni ◽  
...  

66 Background: MPI is an effective tool for geriatric assessment in elderly patients (pts). An oncological version of MPI (Onco-MPI) has been validated by our group in pts with cancer. We evaluate here the prognostic role of Onco-MPI in pts affected by urological cancer. Methods: Pts aged ≥70 years with prostate, renal and urothelial cancer (bladder or upper urinary tract) referred to the Medical Oncology 1 Unit from Jan 2005 to Aug 2019 received a basal comprehensive geriatric assessment (CGA). Onco-MPI was calculated by a validated algorithm as a weighted linear combination of the CGA domains as previously described, identifying 3 different prognostic groups: low (scores 0.0-0.46), intermediate (scores 0.47-0.63) and high risk (scores 0.64-1.0). Results: A total of 643 pts were included; 382 with prostate, 121 renal and 140 urothelial cancer. Median age was 77 years (68-95). ECOG PS was 0 in 44%, 1 in 34.2% and >1 in 21.6%; 19.3% had stage I or II disease, 29.7% stage III and 51% stage IV. Median overall survival (OS) was 35.4 months (95% CI 29.5-41.2). Onco-MPI score (low vs medium vs high risk) was significantly associated with OS in the overall population as well as in the subgroups of patients with prostate, renal or urothelial cancer (table). In pts with prostate cancer the majority of pts were low risk (93%) and only few intermediate (7%), no one was high risk. Conclusions: Onco-MPI confirmed its prognostic role in elderly pts with prostate, renal and urothelial carcinoma. It may be therefore valuable both in clinical practice for driving decision-making, and in geriatric clinical trials thanks to its standardization.[Table: see text]


Diabetes Care ◽  
2004 ◽  
Vol 28 (1) ◽  
pp. 95-100 ◽  
Author(s):  
S. Nakano ◽  
K. Konishi ◽  
K. Furuya ◽  
K. Uehara ◽  
M. Nishizawa ◽  
...  

Blood ◽  
2017 ◽  
Vol 129 (17) ◽  
pp. 2429-2436 ◽  
Author(s):  
Salomon Manier ◽  
Chia-Jen Liu ◽  
Hervé Avet-Loiseau ◽  
Jihye Park ◽  
Jiantao Shi ◽  
...  

Key Points Two circulating exosomal microRNAs, let-7b and miR-18a, improved survival prediction in patients with MM. Circulating exosomal miRNAs enhanced the stratification of patients with high-risk factors.


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