scholarly journals Ovarian Cryopreservation: An Overview of Current Evidence around the Globe

2021 ◽  
Vol 4 (1) ◽  
pp. 435-445
Author(s):  
Gkrozou F ◽  
Tsonis O
Keyword(s):  
Ovarian Tissue ◽  
Scientific Evidence ◽  
Current Evidence ◽  
Ovarian Tissue Cryopreservation ◽  
Reproductive Techniques ◽  
Efficient Alternative ◽  
Clinical Potential ◽  
Cumulative Evidence ◽  
Tissue Cryopreservation

Advancements in cancer as well as, autoimmunological or hematological conditions treatment have significantly increased the survival rate as well as, the Quality of Life (QoL) for these patients. In addition, Assisted Reproductive Techniques (ART) offers a variety of therapeutic approaches that aim towards fertility preservation and hormonal restoration after treatment. Ovarian Tissue Cryopreservation (OTC) and Ovarian Tissue Transplantation (OTT) have been proposed as an efficient alternative to reserve fertility and hormona function in cases of prepubertal young girls and women needed to be treated immediately with radiation and/or chemotherapy. In this narrative review, current scientific evidence is summarized in order to explore OTC/OTT. In addition to the qualitive presentation of our findings, we provide cumulative evidence from other published studies to demonstrate the clinical potential and limitations of these procedures.

scholarly journals Female Fertility Preservation in Patients with Musculoskeletal Cancer

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 2
Author(s):  
D. Mihai ◽  
A. Velișcu ◽  
D. Comandașu ◽  
C. Coroleucă ◽  
C. Mehedințu ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
Ovarian Tissue ◽  
Young Patients ◽  
Endocrine Function ◽  
Ovarian Tissue Cryopreservation ◽  
Premature Menopause ◽  
Musculoskeletal Tumor ◽  
Female Fertility Preservation ◽  
Tissue Cryopreservation

Abstract Introduction. Besides the improvement of the survival rate in young patients with musculoskeletal cancer, we should always consider that infertility and premature menopause due to treatment might dramatically affect their quality of life. Material and methods. This article is a review of literature. Results. After puberty, the first option should be ovarian controlled hyperstimulation (COS) resulting in oocytes that are consequently fertilized using FIV or ICSI and the cryopreservation of the embryos. If the patient does not have a partner at that moment, the next method is the vitrification of the oocytes resulting from the COS. The disadvantages of using COS are the need to postpone the radio and chemotherapy for at least 2-3 weeks and high oestradiol levels, but there are very few hormone dependent musculoskeletal tumors that may be affected. Ovarian tissue cryopreservation (OTC), with ovarian tissue transplantation (OTT) is the only method used if the patient is before puberty, plus, this technique allows patients to spontaneously conceive, if they do not have any other fertility pathology, but this freezing/ thawing procedure may have success or not. There is currently no evidence to suggest that OTT causes reseeding of the original cancer, and the restoring of the ovarian endocrine function was reported in about 95% of the cases. Conclusions. The success of fertility preservation techniques is related to the cryopreservation methods used and the age of the patient. The reproductive cells with the best survival are the embryos, the next are oocytes, or ovarian tissue may be cryopreserved. For best outcomes, the fertility preservation must be pluridisciplinary discussed, involving the ART specialist gynecologist, the oncologist and the surgeon of the musculoskeletal tumor.

Ovarian Tissue Cryopreservation: Promises and Uncertainties

2009 ◽  
Vol 16 (2) ◽  
pp. 173-183
Author(s):  
Guido de Wert ◽  
Els Olsthoorn-Heim
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Ovarian Tissue ◽  
Working Party ◽  
Experimental Treatment ◽  
Ovarian Tissue Cryopreservation ◽  
Main Question ◽  
Regular Treatment ◽  
Tissue Cryopreservation

AbstractCancer in children and young adults is increasingly being cured by operations, radiotherapy and/or chemotherapy. However, one of the serious side effects of these treatments is the risk of damage to fertility. Whereas the most important goal used to be survival, now increasing attention is being paid to the quality of life in the long term, thanks to the success of these treatments. Infertility affects the quality of life. In post-pubescent boys and men semen can be frozen for later use prior to treatment that harms the spermatogenesis. In girls and young women the solution for reduced fertility or infertility after ovary damaging treatment, may consist of the cryopreservation of ovarian tissue prior to this treatment. At a later stage a decision can be made to transplant this ovarian tissue into the patient or to follow an IVF procedure. There are important normative questions regarding this experimental treatment. The main question is, whether it may be introduced in health care as a regular treatment or should be subject to medical research first. In the Netherlands, a working party of both doctors and ethical, legal and psychological experts recommended to carry out proper research before introducing ovarian tissue cryopreservation in regular health care. This article is meant to elucidate this policy and, including some relevant updates, thus to contribute to the discussion on this question in other European countries.

scholarly journals Ovarian tissue cryopreservation from contemporary indications to cutting edge research

2018 ◽  
Vol 1 (1) ◽  
pp. 39-47
Author(s):  
Limor Man ◽  
Zev Rosenwaks ◽  
Daylon James
Keyword(s):  
Quality Of Life ◽  
Ovarian Tissue ◽  
Reproductive Potential ◽  
Cutting Edge ◽  
Ovarian Tissue Cryopreservation ◽  
Major Focus ◽  
Major Side Effect ◽  
Medical Interventions ◽  
Tissue Cryopreservation

Over the last three decades, survival rate from malignancies has steadily increased, turning major focus on quality of life in remission. Unfortunately, a major side effect of medical interventions including chemotherapy, radiotherapy, and/or surgery is premature ovarian failure and infertility for many patients. Ovarian tissue cryopreservation is an experimental technique used to preserve reproductive potential in patients who are pre-pubertal, must urgently undergo gonadotoxic treatment or who have other medical conditions requiring treatment that may undermine ovarian reserve and will lead to sub or infertility. We will review the indications, available techniques of tissue harvesting, and methods for freezing and autotransplanting cortical ovarian tissue. We will discuss outcomes, the potential risk of reintroducing malignancy and lastly, cutting-edge research models being developed in the field.

Ovarian Tissue Cryopreservation in Young Females with Cancer and its Impact on Ovarian Follicle Density

2021 ◽  
Author(s):  
Mindy S. Christianson ◽  
Danielle A. Lukish ◽  
Robert McCarter ◽  
Howard Pryor ◽  
Jeffrey R. Lukish
Keyword(s):  
Ovarian Tissue ◽  
Ovarian Follicle ◽  
Ovarian Tissue Cryopreservation ◽  
Young Females ◽  
Tissue Cryopreservation

scholarly journals Ovarian tissue freezing and activation after thawing: an update

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Li-fan Peng
Keyword(s):  
Granulosa Cells ◽  
Clinical Decision Making ◽  
Ovarian Function ◽  
Ovarian Tissue ◽  
Clinical Decision ◽  
The Body ◽  
Endocrine Function ◽  
Ovarian Tissue Cryopreservation ◽  
Main Body ◽  
Tissue Cryopreservation

Abstract Background With the growth of women’s age, ovarian failure can be caused by various factors. For the women who need chemotherapy because of cancer factors, the preservation of fertility is more urgent. The treatment of cancer is also a process in which all tissues and organs of the body are severely damaged, especially in the reproductive system. Main body As a new fertility preservation technology, autologous ovarian tissue cryopreservation and transplantation is developing rapidly and showing great potentiality in preserving ovarian endocrine function of young cervical cancer patients. Vitrification and slow freezing are two common techniques applied for ovarian tissue cryopreservation. Thus, cryopreserved/thawed ovarian tissue and transplantation act as an important method to preserve ovarian function during radiotherapy and chemotherapy, and ovarian cryopreservation by vitrification is a very effective and extensively used method to cryopreserve ovaries. The morphology of oocytes and granulosa cells and the structure of organelles were observed under the microscope of histology; the hormone content in the stratified culture medium of granulosa cells with the diameter of follicle was used to evaluate the development potential of ovarian tissue, and finally the ovarian tissue stimulation was determined by the technique of ovarian tissue transplantation. Conclusions Although there are some limitations, the team members still carry out this review to provide some references and suggestions for clinical decision-making and further clinical research.

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