Vitex agnus-castus Ze 440 extract in the therapy of cyclic mastodynia in women with non-tumor breast damage

Cyclic mastalgia of varying intensity occurs every month in at least 70% of women, persistent pain in the mammary glands of moderate and severe degree is occur in about 50% of patients with benign mastopathy. The cause of mastodynia is the morphofunctional rearrangement of the glandular and stromal components of tissues with the expansion of ducts and proliferation of epithelial structures due to a lack of progesterone and an increase in prolactin levels. Therapy for cyclical and chronic mastalgia is empirical and not always effective. Herbal medicine with Vitex agnus-castus is a reasonable alternative to hormonal treatment for women suffering from cyclic mastalgia in combination with other manifestations of premenstrual syndrome. The main effect of such drugs is an increase of luteinizing hormone and progesterone synthesis, effect on the hypothalamic-pituitary system, prolactin and endorphins release, which can increase the level of endogenous opioids.Purpose of the study: to study the effect of the phytopreparation Prefemin (Vitex agnus-castus extract Ze 440) on the intensity of chronic pain syndrome in women with diffuse non-tumor breast lesion. Materials and methods. The study involved 30 women aged 22 to 43 years with various types of benign breast diseases and chest pain lasting at least 3 months. In 12 patients there was diffuse fibroadenoma, in 18 – diffuse cystofibroadenoma (small cystic variant) and duct ectasia.Results. Therapy with Prefemin (Ze 440) allowed to completely eliminate pain syndrome in 93.3% of women and to reduce the frequency of mastodynia in the group with moderate severity in 90.0% of patients with diffuse fibroadenoma and cystofibroadenoma.Conclusions. Phytopreparation Prefemin, which is obtained from the medicinal plant Vitex agnus-castus, has demonstrated high efficacy in the mastalgia treatment in women with diffuse fibrocystic breast disease. This drug was well tolerated and there were no side effects.

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Modern view on treatment of patients with fibrocystic mastopathy

HEALTH OF WOMAN ◽

10.15574/hw.2016.112.149 ◽

2016 ◽

pp. 149-152

Author(s):

I.I. Smolanka ◽

◽

A.D. Loboda ◽

Keyword(s):

Transient Elastography ◽

Pain Syndrome ◽

Average Diameter ◽

Breast Disease ◽

Average Degree ◽

Tissue Density ◽

Fibrocystic Breast Disease ◽

Cystic Component ◽

Unbearable Pain ◽

Average Size

The aim of the study: to determine the effectiveness of the drug Epigalin® Brest in the treatment of fibrocystic breast disease in women. Materials and methods. The study included 50 women with an established diagnosis of fibrocystic breast disease (diffuse cystic mastopathy). All women complained of pain and swelling of both breast 3-20 days before the start of menstruation. By blind randomization, all women were divided into 2 groups. Patients of the first group used the drug Epigalin® Brest 1 tablet 2 times a day for three months. Patients of the second group used the drug prostrate summer cypress on the approved user scheme. Patients of both groups did not differ in age (from 22 to 48 years, mean age 35 years). All patients during General examination were performed ultrasound of the breast, and patients older than 40 years also performed the mammogram. Patients of both groups were found multiple cysts in both breasts, the size of which ranged from 3 mm to 22 mm. the average size of the cysts groups were comparable. To assess the effectiveness of treatment in both groups was determined by three parameters: 1. Pain in the Breasts, which were evaluated on a scale from 0 (no pain) to 10 (unbearable pain). 2. Tissue density breast, to determine which was performed by transient elastography (kPa). 3. The average diameter of the cyst. Results. According to the study in the first group identified the implementation of a positive effect of the drug Apigalin Brest. Patients in this group there was a decrease in the average degree of pain, i.e. the patient almost did not feel pain before menstruation, and the complete absence of cystic elements in the Breasts was detected in 90% of patients. No patient noted the deterioration of the breast during the observation. Patients of the second group the average degree of pain, but 10% of the patients noted aggravation of pain syndrome after discontinuation of the drug prostrate summer cypress. In 15% of patients in this group appeared again cysts, and their average diameter began to increase. Tissue density of the breast tended to increase. Conclusion. 1. Complex herbal preparation Epigalin® Brest is effective in the treatment of mastitis. In the case of regular use Apigalin Brest reduce by 68% the presence of cystic component in women with mastopathy. 2. Epigalin® Brest with regular use reduces the density of the tissue of the breast, realizing the function of oncoprotektor. 3. Epigalin® Brest significantly reduces pain before menstruation, which considerably improves the quality of life. Key words: mastopathy, pain, breast gland, treatment, Epigalin® Brest.

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Gynecology: Breast Lesion/Fibrocystic Breast Disease: Mastalgia

10.1542/9781610020732-31 ◽

2017 ◽

pp. 66-67

Keyword(s):

Breast Lesion ◽

Breast Disease ◽

Fibrocystic Breast Disease

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Breast Reduction for Fibrocystic Breast Disease: a case report

Community Based Medical Journal ◽

10.3329/cbmj.v7i2.55454 ◽

2018 ◽

Vol 7 (2) ◽

pp. 42-44

Author(s):

Taslima Sultana ◽

Maruf Alam ◽

Shakhawat Hossain

Keyword(s):

Breast Cancer ◽

Case Report ◽

Connective Tissue ◽

Breast Reduction ◽

Breast Disease ◽

Breast Diseases ◽

Fibrocystic Disease ◽

Breast Reduction Surgery ◽

Fibrocystic Breast Disease ◽

Clinical Correlate

The pathophysiology of fibrocystic breast disease is determined by estrogen predominance that results in hyper proliferation of connective tissue (fibrosis), the risk of breast cancer is increased twofold to fourfold in these patients. The clinical correlate of fibrocystic disease is reflected by breast and axillary pain or tenderness. The disease progresses with advancing premenopausal age and is most pronounced in women during their 40s. We present a case of 23 years old lady who completely get rid of her symptoms from heavy breast with diagnosed fibrocystic changes immediately after breast reduction surgery. Breast reduction can be a treatment option for fibrocystic breast diseases which are not responding to medical treatment. CBMJ 2018 July: Vol. 07 No. 02 P: 42-44

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Fibrocystic breast disease following treatment with selective serotonin reuptake inhibitors

American Journal of Psychiatry ◽

10.1176/ajp.152.3.471a ◽

1995 ◽

Vol 152 (3) ◽

pp. 471a-471 ◽

Cited By ~ 1

Keyword(s):

Serotonin Reuptake ◽

Selective Serotonin Reuptake Inhibitors ◽

Breast Disease ◽

Serotonin Reuptake Inhibitors ◽

Selective Serotonin ◽

Fibrocystic Breast Disease

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Polycystic ovary syndrome and fibrocystic breast disease: is there any association?

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-008-0889-8 ◽

2009 ◽

Vol 280 (2) ◽

pp. 249-253 ◽

Cited By ~ 5

Author(s):

Ilknur Inegol Gumus ◽

Asli Koktener ◽

Dilek Dogan ◽

Nilgun Ozturk Turhan

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Breast Disease ◽

Ovary Syndrome ◽

Fibrocystic Breast Disease

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Methylxanthines and fibrocystic breast disease

Reactions ◽

10.1007/bf03273098 ◽

1981 ◽

Vol 41 (1) ◽

pp. 10-10

Keyword(s):

Breast Disease ◽

Fibrocystic Breast Disease

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A Comparison of Mammography and Ultrasonography in the Evaluation of Breast Masses in Early Stage

Al-Kitab Journal for Pure Sciences ◽

10.32441/kjps.02.02.p14 ◽

2018 ◽

Vol 2 (2) ◽

pp. 209-220

Author(s):

Salwa Sadoon ◽

Muhammed Naseer ◽

Sameerah Saadoon ◽

Hadeel Ahmed

Keyword(s):

Early Stage ◽

Phyllodes Tumor ◽

Breast Disease ◽

Breast Diseases ◽

Prospective Clinical Study ◽

Simple Cyst ◽

Secondary Sexual Characteristics ◽

Breast Examination ◽

Sexual Characteristics ◽

Palpable Breast

Breasts are one of the secondary sexual characteristics in females. They are the rout for of nutrition & growing of infant till 4-6 months of age. Breast diseases are one of the most common diseases in the females of any society. Multiple types of benign breast lesions like fibroadenomas, simple cyst, breast abscess, lymph nodes enlargement and different malignancies are common pathologies of the breast. Up to 30% of women suffer from benign breast disease at any time of their life and this compels them to take the treatment. The prospective clinical study was achieved for 283 women ( age was ranged between 20 60 years) had palpable breast lesion referred by their managing surgeons to the radiological department at Azadi Teaching Hospital, for a period of 8 months (from January 2018 to August of the same year). The study depended firstly in all women on clinical examination/self-breast examination. Results:- 283 patients were included in this study with age between 20 _ 60 ys, most of the patients were diagnosed as fibroadenoma which is most common around 54.9% of the total cases studied, Fibrocystic diseases (Duct ectasia, cysts, and galactocele ) 19.3 %.Followed by infection as mastitis 15.4%, and phyllodes tumor less than 1% approximately and finally carcinoma 9.5%.

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