A STUDY OF CEREBROSPINAL FLUID, C-REACTIVE PROTEIN AND ADENOSINE DEAMINASE LEVELS IN MENINGITIS IN ADULTS

Background: Acute encephalopathy during childhood represents a highly heterogeneous group of infectious and non-infectious pathologies. According to a recent nationwide survey on acute childhood encephalopathy in Japan, the combination of clinical and radiographic features left approximately half of the affected children unclassified, mainly because of the lack of disease-specific biomarkers. Case: Herein, we document a school-aged boy who manifested with acute encephalopathy that was characterized by a prolonged fever, altered mental status, urinary retention, and intention tremor lasting for more than a month. Accompanying features included syndrome of inappropriate secretion of antidiuretic hormone, pleocytosis with elevated interleukin-6 and interferon-gamma levels in the cerebrospinal fluid, and a transient splenial lesion on neuroimaging. No pathogens were identified, and C-reactive protein was negative throughout his clinical course. This constellation of clinical features was not compatible with any of the existing entities of acute pediatric encephalopathy. Discussion: Our retrospective literature review identified two additional school-aged male patients who exhibited highly similar clinical courses. The prolonged altered mental status with pleocytosis in the cerebrospinal fluid and a transient splenial lesion in the absence of serum inflammatory markers suggest a primary central nervous system pathology. Conclusion: This combination of features defines this presumably new group of acute childhood febrile encephalopathy with prolonged fever and ataxia in school-aged boys.

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Study of serum adenosine deaminase activity and c-reactive protein in patients of rheumatoid arthritis

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.4724 ◽

2020 ◽

Vol 11 (4) ◽

pp. 7990-7993

Author(s):

Sangeetha R ◽

Ramesh Raju K A P ◽

Hemapriya S ◽

Suganthi V ◽

Panneerselvam P

Keyword(s):

Rheumatoid Arthritis ◽

Adenosine Deaminase ◽

Treatment Plan ◽

Colorimetric Method ◽

Disease Score ◽

C Reactive Protein ◽

Positive Correlation ◽

Reactive Protein ◽

Adenosine Deaminase Activity

Rheumatoid arthritis (RA) is a chronic disease that causes inflammatory synovitis. The treatment plan of RA includes reducing inflammation and improving the quality of life. Hence, understanding the role of Adenosine deaminase (ADA) and C-reactive protein helps for a better plan of treatment. The present study was undertaken to determine the serum ADA activity and CRP in RA patients and correlate with the severity of the progression of the disease. 25 patients diagnosed with RA as per 2010 ACR/EULAR criteria and 25 age and sex matched healthy controls were included in the study after informed consent. Blood samples were collected from all the subjects after an overnight fast, serum separated was analyzed immediately for Adenosine deaminase(ADA) activity measured using colorimetric method of Guisti and Galanti. Disease score, C-reactive protein, RA factor, ADA and ESR were significantly higher in cases when compared with controls. Significant positive correlation was present between the disease score and C-reactive protein, RA factor among cases. A positive correlation was observed between the disease score and ADA, but it was not statistically significant among cases.

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Diagnostic and prognostic value of procalcitonin (PCT), C reactive protein (CRP), nitric oxide (NO) levels, and adenosine deaminase (ADA) activity in sheep with natural babesiosis before and after treatment

TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES ◽

10.3906/vet-1805-35 ◽

2018 ◽

Vol 42 (6) ◽

pp. 512-520

Author(s):

Sezai ARSLAN ◽

Nuri ALTUĞ ◽

Mustafa Necati MUZ ◽

Nazmi YÜKSEK ◽

Yıldıray BAŞBUĞAN ◽

...

Keyword(s):

Nitric Oxide ◽

Adenosine Deaminase ◽

Prognostic Value ◽

C Reactive Protein ◽

Reactive Protein ◽

Before And After ◽

Diagnostic And Prognostic Value

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Survay of Cerebrospinal Fluid (CSF and C-Reactive Protein (CRP) for Differentiation of Bacterial and Viral Meningitis in Loghman Hakim, Aliasghar and Valiasr Hospitals of Zanjan

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2008.05.1298 ◽

2008 ◽

Vol 12 ◽

pp. e462

Author(s):

D.R. Asadi ◽

B. Amini

Keyword(s):

Cerebrospinal Fluid ◽

Viral Meningitis ◽

C Reactive Protein ◽

Reactive Protein

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C - reactive protein of cerebrospinal fluid, as a sensitive approach for diagnosis of neonatal meningitis

African Health Sciences ◽

10.4314/ahs.v19i3.10 ◽

2019 ◽

Vol 19 (3) ◽

pp. 2372-2377

Author(s):

Shima Javadinia ◽

Mohsen Tabasi ◽

Mehri Naghdalipour ◽

Najmosadat Atefi ◽

Ramin Asgarian ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Aseptic Meningitis ◽

Great Majority ◽

Diagnostic Value ◽

Latex Agglutination ◽

Neonatal Meningitis ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Permanent Brain Damage

Background: Meningitis, is a potentially life-threatening condition that can rapidly progress to permanent brain damage, neurologic problems, and even death. Bacteria and viruses cause the great majority of meningitis disease in infants and children. CRP is used mainly as a marker of inflammation.Objective: This study was conducted to assess the diagnostic value of CSF-CRP levels for differentiating between septic (bacterial) and aseptic infantile meningitis.Methods: 49 hospitalized infants aged less than two months with suspected meningitis were enrolled in a cross-sectional analytic study. All of patients underwent lumbar puncture to obtain CSF. smears, cultures, cytological and biochemical analysis and latex agglutination testing were carried out on all CSF samples. Latex agglutination test was carried out on all CSF samples using a commercially available kit. CSF-CRP level of all infants was measured using the immunoturbidometric technique.Results: Of 49 infants in this study, 20 and 29 cases were diagnosed as septic and aseptic meningitis, respectively. The CRP levels were obtained as 0.95±0.68 mg/L in septic and 0.16±0.36 mg/L in aseptic meningitis groups and this difference was statistically significant (p<0.001) between the two groups (0.79±0.32 mg/L). Based on the ROC curve, cut off levels for CRP was obtained 0.17 mg/L. At this level, there was 95% sensitivity and 86% specificity to differentiate septic and aseptic meningitis.Conclusion: CSF-CRP has suitable diagnostic value in distinguishing between infantile bacterial from aseptic meningitis especially in cases of negative bacterial culture of the blood and spinal fluid.Keywords: C-reactive protein, cerebrospinal fluid, septic/aseptic meningitis, infant, diagnostic value.

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