Effect of Quercetin on Liver Oxidative Stress Parameters Induced by Butylparaben in Male Wistar Rats

Background Chronic and degenerative diseases are closely related to modern lifestyles that tend to be deficient in physical activity but excessive in food intake. One method used to overcome this problem is dietary restriction through intermittent fasting. Intermittent fasting decreases the risk of chronic and degenerative diseases, e.g. by lowering oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and lipid profile in the blood. The present study aimed to determine the effect of intermittent fasting on plasma MDA levels and lipid profile of Wistar rats (Rattus norvegicus). Methods This research was a laboratory experimental research using a post test control group design. Twenty four male Wistar rats (Rattus norvegicus) were randomly assigned to 4 groups, ie control group (C), fasting group (F), non-fasting obese group (NFO), and fasting obese group (FO). Fasting treatment given in this research was intermittent fasting, comprising one day of fasting for 12 hours alternating with one day of normal feed ad libitum in the span of 8 weeks. After completion of treatment, blood was taken transcardially for examination of MDA levels and lipid profiles using spectrophotometry. Results There were significant between-group differences in MDA levels and lipid profiles (p<0.05 for all parameters). Groups treated with intermittent fasting had lower levels of MDA, total cholesterol, triglycerides, and ow-density lipoprotein (LDL) than those without intermittent fasting. The high-density lipoprotein (HDL) levels were higher in the intermittent fasting group than the other groups. Conclusion Intermittent fasting has an effect on the oxidative stress parameters of Wistar rats (Rattus norvegicus).

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Oxidative stress parameters in erythrocytes, plasma and livers of young and aged Wistar rats

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2012.08.153 ◽

2012 ◽

Vol 53 ◽

pp. S74

Author(s):

T.P. Popovic⁎ ◽

S.B. Borozan ◽

A.A. Arsic ◽

S.L. de Luka ◽

V.V. Vucic ◽

...

Keyword(s):

Oxidative Stress ◽

Wistar Rats ◽

Oxidative Stress Parameters ◽

Stress Parameters

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Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats

Translational Psychiatry ◽

10.1038/s41398-019-0637-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Samira S. Valvassori ◽

Paula T. Tonin ◽

Gustavo C. Dal-Pont ◽

Roger B. Varela ◽

José Henrique Cararo ◽

...

Keyword(s):

Oxidative Stress ◽

Frontal Cortex ◽

Oxidative Stress Biomarkers ◽

Oxidative Stress Parameters ◽

Stress Biomarkers ◽

Novel Approach ◽

Male Wistar Rats ◽

And Oxidative Stress ◽

Cerebral Structures ◽

Stress Parameters

Abstract The present study intends to investigate the effect of lithium (Li) and celecoxib (Cel) coadministration on the behavioral status and oxidative stress parameters in a rat model of mania induced by dextroamphetamine (d-AMPH). Male Wistar rats were treated with d-AMPH or saline (Sal) for 14 days; on the 8th day of treatment, rats received lithium (Li), celecoxib (Cel), Li plus Cel, or water until day 14. Levels of oxidative stress parameters were evaluated in the serum, frontal cortex, and hippocampus. d-AMPH administration induced hyperlocomotion in rats, which was significantly reversed by Li and Cel coadministration. In addition, d-AMPH administration induced damage to proteins and lipids in the frontal cortex and hippocampus of rats. All these impairments were reversed by treatment with Li and/or Cel, in a way dependent on cerebral area and biochemical analysis. Li and Cel coadministration reversed the d-AMPH-induced decrease in catalase activity in cerebral structures. The activity of glutathione peroxidase was decreased in the frontal cortex of animals receiving d-AMPH, and treatment with Li, Cel, or a combination thereof reversed this alteration in this structure. Overall, data indicate hyperlocomotion and alteration in oxidative stress biomarkers in the cerebral structures of rats receiving d-AMPH. Li and Cel coadministration can mitigate these modifications, comprising a potential novel approach for BD therapy.

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