scholarly journals Choice of a Method for Blocked Intramedullary Osteosynthesis in Tibial Fractures in the Context of Topographic-Anatomical Research

2021 ◽  
Vol 10 (1) ◽  
pp. 41-48
Author(s):  
A. S. Marchenko ◽  
N. F. Fomin ◽  
F. S. Grigoryan
Keyword(s):  
Bone Marrow ◽  
Anatomical Study ◽  
Vascular Supply ◽  
Lower Limbs ◽  
X Ray ◽  
Marrow Cavity ◽  
Tibial Bone ◽  
Narrow Part ◽  
Intramedullary Osteosynthesis ◽  
Bone Marrow Cavity

Blocked intramedullary osteosynthesis has become a "gold standard" for the treatment of patients with diaphyseal fractures of the tibia. However, there is still debate about the importance and necessity of reaming the bone marrow cavity when performing intramedullary osteosynthesis.The aim is to study the individual features of the structure of the medullary cavity of the tibia in relation to intramedullary osteosynthesis, as well as to evaluate the effect of blocked intramedullary osteosynthesis with preliminary reaming and without reaming of the bone marrow cavity on the vascular supply of the tibia.Material and methods. Using morphometric and radiological methods, an experimental topographical and anatomical study was carried out on 26 dry preparations and histotopograms-plates of tibial bone cuts, as well as on 10 lower limbs of corpses with X-ray contrast injection of arterial vessels. Statistical analysis was performed using the Student's parametric test and the nonparametric MannWhitney test.Results. Particular attention was paid to the detailed study of the main parameters of the tibial bone marrow cavity that are important for the technology of blocked intramedullary osteosynthesis (size, shape and curves of the bone marrow cavity, architectonics of its narrow part, density and distribution of spongy matter in it, topography of the a. nutricia tibialis channel and distribution of its branches). To assess the invasiveness of osteosynthesis on 10 anatomical objects with preliminary injection of vessels of the lower extremity with X-ray contrast mass, blocked intramedullary osteosynthesis of the tibia with and without reaming of the bone marrow cavity was modeled.Conclusion. It was concluded that any variant of intramedullary rod insertion is accompanied by damage to a. nutricia tibialis in a narrow part of the bone marrow cavity, and reaming of the bone marrow cavity has certain advantages in view of the pronounced individual differences in the structure of the tibia.

Expression of bone sialoprotein mRNA during bone formation and resorption induced by colchicine in rat tibial bone marrow cavity

2009 ◽  
Vol 10 (8) ◽  
pp. 1209-1217 ◽  
Author(s):  
N. Arai ◽  
K. Ohya ◽  
S. Kasugai ◽  
H. Shimokawa ◽  
S. Ohida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Sialoprotein ◽  
Marrow Cavity ◽  
Tibial Bone ◽  
Bone Marrow Cavity

The Bone Marrow Cavity Is Suitable for Islet Transplantation in Diabetic Rhesus Monkey.

2014 ◽  
Vol 98 ◽  
pp. 360-361
Author(s):  
L. Yan-rong ◽  
C. Wang ◽  
X. Du ◽  
S. He ◽  
Y. Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rhesus Monkey ◽  
Islet Transplantation ◽  
Marrow Cavity ◽  
Bone Marrow Cavity

Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice

Blood ◽  
2000 ◽  
Vol 95 (11) ◽  
pp. 3363-3370 ◽  
Author(s):  
Hisashi Tagaya ◽  
Takahiro Kunisada ◽  
Hidetoshi Yamazaki ◽  
Toshiyuki Yamane ◽  
Takeshi Tokuhisa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Strains ◽  
B Lymphopoiesis ◽  
Hematopoietic Growth Factors ◽  
Newborn Mice ◽  
Marrow Cavity ◽  
Interleukin 7 ◽  
Neonatal Stage ◽  
Bone Marrow Cavity ◽  
B Lineage

Adult bone marrow is a major site for hematopoiesis, and reduction of the bone marrow cavity induces hematopoiesis in extramarrow tissues. To investigate the rudimentary intramarrow and the compensatory extramarrow hematopoiesis, particularly B lymphopoiesis, we used 3 osteopetrotic mouse strains [op/op, mi/mi, and Fos(−/−)], which are severely deficient in functional osteoclasts and therefore form inadequate bone marrow cavities. We found that bone marrow in these osteopetrotic mice supports myelopoiesis but not B lymphopoiesis, although cells that have the potential to differentiate into B lineage cells are present in the bone marrow. Although B lymphopoiesis normally occurs both in the spleen and liver of newborn mice, compensatory B lymphopoiesis in adultop/op and mi/mi mice is observed only in the liver, while myelopoiesis is enhanced in both organs. Interestingly, mice lacking the Fos proto-oncogene exhibit B lymphopoiesis in the spleen as well as liver. The amounts of expression of steel factor, Flt3/Flk-2 ligand, and interleukin-7 in the bone marrow, spleen, or liver were not significantly affected in these osteopetrotic mutants. These findings suggest that the volume of the bone marrow cavity regulates B lymphopoiesis without affecting the production of certain hematopoietic growth factors. The splenic microenvironments that support both myelopoiesis and B lymphopoiesis in the neonatal stage are lost in adults and are not reactivated even in the osteopetrotic adults unless the Fos gene is disrupted.

scholarly journals Changes in the structural organization of bone after amputation

2020 ◽  
Author(s):  
Viktor Ivanovych Shevchuk ◽  
Yurii Oleksiiovych Bezsmertnyi ◽  
Halyna Viktorivna Vezsmertna ◽  
Tetyana Viktorivna Dovgalyuk ◽  
Yankai Jiang
Keyword(s):  
Bone Marrow ◽  
Structural Organization ◽  
Muscle Tension ◽  
Bone Plate ◽  
Tight Closure ◽  
Marrow Cavity ◽  
Normal Bone ◽  
Reparative Process ◽  
Bone Marrow Cavity ◽  
Series Of Experiments

Introduction: Despite a considerable amount of work on limb amputations, questions of the mechanism and conditions for the occurrence of pathological rearrangement in the bone stump and ways to prevent it remain unexplored. Aim: To study the nature of changes in the structural organization of bone stump after amputation. Material and methods: Nine series of experiments were conducted on 129 rabbits with amputation of the thigh and closure of the filing with fascia, muscles with varying degrees of tension and a bone plate. Duration of observation is 1, 3, and 6 months. The research method is histological with a filling of blood vessels with a mascara-gelatin mixture. Results and discussion: Tight closure of the bone marrow cavity and uniform muscle tension during plastic surgery in the I–III series of experiments make it possible to obtain cylindrical stumps with the formation of a bone closure plate and the completion of the reparative process. In the majority of observations of the IV–IX series, significant violations of the structural organization of the bone occurred in the form of conical, club-shaped, swollen stumps, creeping fractures. Conclusions: The rapid completion of the reparative process and the normalization of intraosseous circulation with a locking bone plate, while maintaining normal bone marrow tissue, is possible only with a dense closure of the filing. The lack of tight closure of the bone marrow canal and uneven muscle tension cause a violation of regeneration with changes in the structural organization of the bone. These changes are manifested by a thickening of the bone diameter, axis curvature, creeping fractures.

Intramarrow injection needle: a new technique to treat patients with haematological and non-haematological malignancies by directly injecting therapeutic agents into the bone marrow cavity

2020 ◽  
Vol 73 (9) ◽  
pp. 552-556
Author(s):  
Anwarul Islam
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Therapeutic Agents ◽  
External Diameter ◽  
Blood Products ◽  
Intravenous Therapy ◽  
Marrow Cavity ◽  
New Instrument ◽  
Bone Marrow Cavity ◽  
A New Technique

AimsThe purpose of this report is to describe a new instrument designed for the injection of therapeutic agents directly into the bone marrow cavity as well as to aspirate bone marrow specimens for the diagnostic purposes.MethodsThe instrument consists of three parts: the needle, stilette and an adjustable guard. The overall length of the needle is 76 mm and has uniform external diameter except for the distal penetrating segment, which is sharp but short and safe to use on the sternum. The proximal end of the needle is fitted with a plastic T-bar handle, which is ergonomically designed for firm grip and easy manoeuvrability.ResultsThe instrument has been designed to obtain bone marrow aspirate specimens as well as to inject therapeutic agents into the posterior ilium.ConclusionsThe rationale for the intramedullary injection of therapeutic agents for the treatment of patients with leukaemia, lymphoma and other haematological and non-haematological malignant disorders is described. In an emergency when intravenous therapy becomes difficult due to collapsed veins, this instrument may be used for direct intramarrow infusion of blood and blood products.

scholarly journals Stem cell niche-specific Ebf3 maintains the bone marrow cavity

2018 ◽  
Vol 32 (5-6) ◽  
pp. 359-372 ◽  
Author(s):  
Masanari Seike ◽  
Yoshiki Omatsu ◽  
Hitomi Watanabe ◽  
Gen Kondoh ◽  
Takashi Nagasawa
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Marrow Cavity ◽  
Bone Marrow Cavity ◽  
Cell Niche
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